Výsledky vyhledávání - "L. W. Mitcheltree"

Characterization of sulfur mustard vapor-induced cutaneous lesions on haired guinea pigs

Autor: R. A. Way, R. B. Lee, Ernest H. Braue, R. G. Rieder, L. W. Mitcheltree, C. R. Nails, J. E. Zallnick

Publikováno v: Skin Research and Technology. 4:99-108

Summary: The identification ofantivesicant compounds has been hindered by the lack of a suitable in vivo model. Our laboratory has been evaluating the hairless guinea pig as a useful animal model to mrmic the human cutaneous response to sulfur mustar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf2a6dcd940fd286408edbc905055ba
https://doi.org/10.1111/j.1600-0846.1998.tb00094.x

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Nikolsky's sign: a novel way to evaluate damage at the dermal-epidermal junction*

Autor: J. E. Zallnick, Ernest H. Braue, C. R. Nalls, L. W. Mitcheltree, R. A. Way, R. G. Rieder

Publikováno v: Skin Research and Technology. 3:245-251

Background/aims: Sulfur mustard (2,2′-dichlorodiethyl sulfide, HD) is a potent vesicating (blistering) agent. Cutaneous exposure causes the destruction of basal cells and leads to a separation at the dermal-epidermal junction. To evaluate the effic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4618719073f5cb7b0dd89db0d9d40b
https://doi.org/10.1111/j.1600-0846.1997.tb00193.x

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Therapeutic approaches to dermatotoxicity by sulfur mustard. I. Modulaton of sulfur mustard-induced cutaneous injury in the mouse ear vesicant model

Autor: R P, Casillas, R C, Kiser, J A, Truxall, A W, Singer, S M, Shumaker, N A, Niemuth, K M, Ricketts, L W, Mitcheltree, L R, Castrejon, J A, Blank

Publikováno v: Journal of applied toxicology : JAT. 20

The mouse ear edema model is recognized for its usefulness in studying skin responses and damage following exposure to chemical irritants, and for evaluating pharmacological agents against chemically induced skin injury. We recently modified the mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8607629e75b8068ec76cee40bf2e024
https://pubmed.ncbi.nlm.nih.gov/11428628

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Systemic administration of candidate antivesicants to protect against topically applied sulfur mustard in the mouse ear vesicant model (MEVM)

Autor: M C, Babin, K, Ricketts, J P, Skvorak, M, Gazaway, L W, Mitcheltree, R P, Casillas

Publikováno v: Journal of applied toxicology : JAT. 20

The mouse ear vesicant model (MEVM) provides a quantitative edema response as well as histopathological and biochemical endpoints as measurements of inflammation and tissue damage following exposure to the chemical warfare agent sulfur mustard (HD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7b9da6a6eef0c2a55232e3521f2db80
https://pubmed.ncbi.nlm.nih.gov/11428627

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Niacinamide pretreatment reduces microvesicle formation in hairless guinea pigs cutaneously exposed to sulfur mustard

Autor: J J, Yourick, C R, Clark, L W, Mitcheltree

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 17(3)

It has been proposed that sulfur mustard (HD) may indirectly activate poly(ADP-ribose) polymerase (PADPRP) by alkylating cellular DNA (Papirmeister et al., 1985). Activation of PADPRP results in the depletion of cellular NAD+, which initiates a serie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d3cca8919a76b05180d105700dcc6772
https://pubmed.ncbi.nlm.nih.gov/1838996

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Hairless guinea pig bioassay model for vesicant vapor exposures

Autor: M M, Mershon, L W, Mitcheltree, J P, Petrali, E H, Braue, J V, Wade

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 15(3)

Sulfur mustard (HD; 1,1'-thiobis[2-chloroethane]) induces fluid-filled blisters in man but not in conventional laboratory animals. An animal model is needed to emulate both cytotoxic (vesicant) and vascular (irritant) responses of human skin to HD ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d872e2ce40a33ef986c1e7b0a7cf881
https://pubmed.ncbi.nlm.nih.gov/2258024

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