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Akademický článek

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Application of a Chain Termination Assay for Characterization of Reverse Transcriptase from AZT-Resistant HIV Isolates

Autor: J. S. Gronowitz, Clas Källander, Johan Lennerstrand, L. Vrang, Ann-Sofie Rytting

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:313-320

An enzymatic assay based on utilization of one primer/enzyme molecule was specifically designed for evaluation of the chain termination capacity of reverse transcriptase (RT) from HIV-1 isolates. In this assay system (CT assay) there was a 3.2-fold d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47c0553a8ed7c91f406b7a48d1bf3783
https://doi.org/10.1177/095632029600700604

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Inhibition of SIV and HIV-2 Replication in Cynomolgus Monkeys by (-)9-[4-Hydroxy-2-(Hydroxymethyl)-Butyl]Guanine (H2G)

Autor: Peter Thomas Lind, L. Vrang, Bo Öberg, Britta Wahren, N. G. Johansson, Per Putkonen, D. Böttiger, R. Noreen, B. Lindborg

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:21-26

The antiherpes compound (-)9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) has been found to suppress the multiplication of SIVsm and HIV-2 in cynomolgus monkeys. This was seen as a delay in the appearance of viral antigen in serum during the prima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb0dfa82e4491e5fb491700caed6d7c0
https://doi.org/10.1177/095632029600700104

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Phenethylthiazolylthiourea (PETT) Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 2. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogs

Publikováno v: Journal of Medicinal Chemistry. 39:4261-4274

Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of non-nucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compounds resulted in the identification of N-[2-(2-pyridyl)ethyl]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996a50dd39f38af704f493f59146bf93
https://doi.org/10.1021/jm950639r

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Influence of the Infectious Dose of Simian Immunodeficiency Virus on the Acute Infection in Cynomolgus Monkeys and on the Effect of Treatment with 3′-Fluorothymidine

Autor: L. Vrang, Bo Öberg, D. Böttiger

Publikováno v: Antiviral Chemistry and Chemotherapy. 3:267-271

Inoculation of cynomolgus monkeys with simian immunodeficiency virus (SIVSM) results in an acute infection with circulating viral antigen. The time for appearance of the viral antigen peak was dependent on the dose of virus given, a reduced dose of v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d3c5fd71037d8e3ab8c2f9dc6ece1fe
https://doi.org/10.1177/095632029200300503

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Screening for new agents

Autor: L. Vrang, B. Öberg

Publikováno v: European Journal of Clinical Microbiology & Infectious Diseases. 9:466-471

Screening for new antiviral drugs is concentrated on a search for inhibitors of the human immunodeficiency virus, herpesviruses, influenza virus, hepatitis B virus and rhinovirus. The first step in the process is usually the screening of virus-infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db7008f22c39c658e542a21f538acc9
https://doi.org/10.1007/bf01964285

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Synthesis of 2′- and 3′-Amino-Substituted Uridine, Thymidine and Adenosine, and Their Inhibitions of HIV Replication

Autor: Jyoti Chattopadhyaya, J.-M. Vial, N. G. Johansson, L. Vrang

Publikováno v: Antiviral Chemistry and Chemotherapy. 1:183-202

Summary Reactions of primary and secondary amines with appropriately protected 2'-O-mesyl-3'-deoxynucleo sides 1, 5, and 18 gave 2',3'-dideoxy-2'-alkylamino nucleosides 2a-d, 6a-c and 19a-d, f, n-q (35-40%) as well as a small amount of 2' ,3'-gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf5d9c7253ed24c7d645d93f6d12849b
https://doi.org/10.1177/095632029000100303

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