Zobrazeno 1 - 10
of 20
pro vyhledávání: '"L. V., Lehka"'
Publikováno v:
The Ukrainian Biochemical Journal, Vol 90, Iss 2, Pp 46-54 (2018)
N-acetylcysteine (NAC) is a dietary supplement demonstrating antioxidant and liver protecting effects that is widely used in clinics. NAC is considered to possess potential therapeutic activity for health disorders characterized by generation of free
Externí odkaz:
https://doaj.org/article/0ff15cce1342428982f60aa823e8581b
Publikováno v:
Біологічні студії, Vol 10, Iss 1, Pp 5-16 (2016)
Landomycin A is a new antibiotic of angucycline group with antineoplastic activity against tumor cells of different origin. In this work, we investigated the effects of landomycin A on the growth of B16F10 mouse melanoma. It was elucidated that studi
Externí odkaz:
https://doaj.org/article/e11e8aab77b14f8cb8b4d268c69d2f34
Publikováno v:
The Ukrainian Biochemical Journal, Vol 87, Iss 5, Pp 72-82 (2015)
Landomycin A (LA) is a new antitumor antibiotic of angucycline group, possessing high antitumor activity against cancer cells of different origin, which induces early apoptosis in target cells. It was shown that under LA action the level of reactive
Externí odkaz:
https://doaj.org/article/88c4e9c6ee684ed49292c6dd2b31fdbb
Autor:
R. R. Panchuk, N. R. Skorokhyd, V. V. Chumak, L. V. Lehka, A. G. Moiseenok, W. Berger, R. S. Stoika
Publikováno v:
Біологічні студії, Vol 7, Iss 3, Pp 33-46 (2013)
The aim of this work was to study biological activity of sodium selenite, selenomethionine and D-panthetine towards drug-resistant human leukemia and carcinoma cells, characterized by overexpression of P-glycoprotein and knockout of Bax gene which pl
Externí odkaz:
https://doaj.org/article/55b254d160e445f280471cbbac9fba5e
Autor:
R. R. Panchuk, V. V. Chumak, N. R. Skorokhyd, L. V. Lehka, S. V. Prylutska, W. Berger, P. Heffeter, R. S. Stoika, Yu. I. Prylutsky
Publikováno v:
Біологічні студії, Vol 7, Iss 1, Pp 5-20 (2013)
Development of new pharmaceutical formulations based on using specific nanoscale carriers for improved drug delivery to target cells is one of crucial tasks of current pharmaceutics. Usage of such nanocomposites does not only extend the duration of
Externí odkaz:
https://doaj.org/article/32fc63bcf1c644b4adcd260c4d11ff7a
Publikováno v:
Біологічні студії, Vol 6, Iss 1, Pp 5-18 (2012)
Study of cellular and molecular mechanisms of anticancer activity of novel perspective angucycline antibiotic landomycin E was carried out. It was revealed that this compound uses mechanisms of apoptosis induction in tumor cells that differ from such
Externí odkaz:
https://doaj.org/article/8293089c6f5147eb88392db0ef0ebbcd
Publikováno v:
Ukrainian Biochemical Journal, Vol 90, Iss 2, Pp 46-54 (2018)
N-acetylcysteine (NAC) is a dietary supplement demonstrating antioxidant and liver protecting effects that is widely used in clinics. NAC is considered to possess potential therapeutic activity for health disorders characterized by generation of free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6546b0458ccdaea71ad4fc83a69035bd
http://ukrbiochemjournal.org/wp-content/uploads/2018/03/Kozak_2_18.pdf
http://ukrbiochemjournal.org/wp-content/uploads/2018/03/Kozak_2_18.pdf
Autor:
Iryna I. Grytsyna, Olga Klyuchivska, Borys S. Zіmenkovsky, Rostyslav Stoika, Marina Starykovych, Roman Lesyk, R. R. Panchuk, Lesya I. Коbylinska, L. V. Lehka, N. S. Finiuk
Publikováno v:
Croatian Medical Journal
Aim To compare various pro-apoptotic effects of synthetic 4-thiazolidinone derivative (Les-3288), doxorubicin (Dox) and temozolomide (TMZ) in the treatment of human glioma U251 cells to improve treatment outcomes of glioblastoma and avoid anticancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f1c3eb34bc1b4cd79dbeefff14b979
https://doi.org/10.3325/cmj.2017.58.150
https://doi.org/10.3325/cmj.2017.58.150
Autor:
R. R. Panchuk, N. R. Skorokhyd, Uwe Ritter, Maxim P. Evstigneev, L. V. Lehka, Yu. I. Prylutskyy, Walter Berger, Petra Heffeter, Rostyslav Stoika, Svitlana Prylutska, V V Chumakl, Peter Scharff
Publikováno v:
Journal of Biomedical Nanotechnology. 11:1139-1152
Development of nanocarriers for effective drug delivery to molecular targets in tumor cells is a real problem in modern pharmaceutical chemistry. In the present work we used pristine C60 fullerene as a platform for delivery of anticancer drug doxorub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3665b4e3fcab1ce870cbd3fed94362ff
https://doi.org/10.1166/jbn.2015.2058
https://doi.org/10.1166/jbn.2015.2058
Autor:
Walter Berger, Theresa Downey, L. V. Lehka, Alessio Terenzi, Sushilla van Schoonhoven, Jürgen Rohr, Irene Herbacek, Rostyslav Stoika, Iryna Kril, R. R. Panchuk, B. P. Matselyukh, Petra Heffeter, Amit Kumar Jha
Landomycin E (LE) is an angucycline antibiotic produced by Streptomyces globisporus. Previously, we have shown a broad anticancer activity of LE which is, in contrast to the structurally related and clinically used anthracycline doxorubicin (Dx), onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c3c535e0d01df8e58634a8c1589bd5
http://hdl.handle.net/10447/392760
http://hdl.handle.net/10447/392760
