Zobrazeno 1 - 10
of 321
pro vyhledávání: '"L. Uharek"'
Publikováno v:
Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie. 6:130-141
Mehr als 20 Jahre nach den ersten Versuchen, die gezeigt haben, dass T-Lymphozyten mittels Gentransfer eines chimaren Antigenrezeptors (CAR) kunstlich mit einer Spezifitat gegen Tumorantigene ausgerustet werden konnen, erzielt dieser Ansatz bahnbrech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f734ab15311a6cd03f4fd8be7e3ed05e
https://doi.org/10.1055/s-0042-110216
https://doi.org/10.1055/s-0042-110216
Autor:
Chiara Gentilini, Thoralf Lange, Effie W. Petersdorf, R. Krahl, U Hegenbart, Haifa Kathrin Al-Ali, Sabine Leiblein, Michael W. Deininger, Ronald Brand, Dietger Niederwieser, Rainer Storb, L Uharek, Wolfram Poenisch
Publikováno v:
Leukemia, 18(9), 1468-1475. Nature Publishing Group
Kinetics of BCR-ABL transcript elimination and its prognostic implications on relapse were analyzed in patients with chronic myeloid leukemia (CML) after reduced intensity hematopoietic cell transplantation (HCT). In all, 19 CML patients were conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e8b7b04e2be830c24d9ab2a59a1572
https://research.rug.nl/en/publications/bc602a5b-63a1-4e28-8f3a-bc6667062d43
https://research.rug.nl/en/publications/bc602a5b-63a1-4e28-8f3a-bc6667062d43
Publikováno v:
British Journal of Haematology. 120:27-35
Idiotype (Id) vaccination provides an interesting immunotherapeutic strategy against B-cell lymphomas. In multiple myeloma (MM), however, the therapeutic efficacy of Id vaccination has been disappointing. In an attempt to improve the antitumoral pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f65ca311282f70be7f25e63b8e152b5
https://doi.org/10.1046/j.1365-2141.2003.03930.x
https://doi.org/10.1046/j.1365-2141.2003.03930.x
Publikováno v:
British Journal of Haematology. 117:93-102
Summary. Idiotype (Id) vaccination provides an innovative treatment modality against B-cell malignancies. In multiple myeloma patients, however, the antitumoral potential of this immunotherapeutic concept is limited. In an attempt to improve the ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90eb8f46d7f8078721d1922b37337303
https://doi.org/10.1046/j.1365-2141.2002.03379.x
https://doi.org/10.1046/j.1365-2141.2002.03379.x
Publikováno v:
British Journal of Haematology. 114:660-665
Natural killer (NK) cells can lyse a variety of different tumour cells by exocytosis of perforin, subsequent binding of perforin to the target cell membrane and formation of lytic pores. Some tumour cells, however, are resistant to cellular cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef346183038aef0e720666a78a758208
https://doi.org/10.1046/j.1365-2141.2001.02995.x
https://doi.org/10.1046/j.1365-2141.2001.02995.x
Publikováno v:
Bone Marrow Transplantation. 27:279-285
The active immunization of bone marrow (BM) donors with myeloma immunoglobulin (Ig) results in an idiotypic T cell response that can be transferred to the recipient. Using a murine model we evaluated the effectiveness, side-effects and underlying mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645e0ba3497ac3e5298eea30481b8588
https://doi.org/10.1038/sj.bmt.1702785
https://doi.org/10.1038/sj.bmt.1702785
Publikováno v:
Blood. 96:594-600
Exocytosis of perforin, subsequent binding of perforin to the target cell membrane, and formation of lytic pores form an important pathway involved in the induction of tumor cell death by cytotoxic effector cells. Here we describe a novel escape mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5028d80a24807867f1b6e4b1c603044a
https://doi.org/10.1182/blood.v96.2.594.014k36_594_600
https://doi.org/10.1182/blood.v96.2.594.014k36_594_600
Autor:
Rolf Kuse, N von Neuhoff, Helmut Löffler, Peter Dreger, Robert Schoch, L. Uharek, B. Glass, Ruth Sonnen, N. Schmitz
Publikováno v:
British Journal of Cancer
B-cell chronic lymphocytic leukaemia (CLL) cannot be cured by conventional therapy. To improve the prognosis of patients with CLL, we have designed a sequential treatment strategy that comprises intensive chemotherapy for mobilization of peripheral b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45dd6f77f338b4851f5473d662151bf
https://doi.org/10.1038/bjc.1998.381
https://doi.org/10.1038/bjc.1998.381
Autor:
Norbert Schmitz, Jörg Steinmann, B. Glass, Peter Dreger, Helmut Löffler, L. Uharek, Matthias Zeis
Publikováno v:
Blood. 90:1694-1700
Peripheral blood progenitor cells (PBPCs) are increasingly being used to replace bone marrow cells (BMCs) as a source of hematopoietic stem cells also in the field of allogeneic transplantation. Whereas it is well known that PBPC grafts and BM differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30181a1ef0ee2fc50ca98405dae410bf
https://doi.org/10.1182/blood.v90.4.1694
https://doi.org/10.1182/blood.v90.4.1694
Autor:
Matthias Zeis, Winfried Gassmann, L. Uharek, B. Glass, Peter Dreger, Jörg Steinmann, Norbert Schmitz
Publikováno v:
British Journal of Haematology. 96:757-761
Allogeneic lymphocytes administered with an unmanipulated bone marrow transplant provide a strong antileukaemic effect, the so-called graft-versus-leukaemia (GVL) effect. On the other hand, T-cell-mediated graft-versus-host-disease (GVHD) observed af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f80958351108d761d6df184b2c7dca
https://doi.org/10.1046/j.1365-2141.1997.d01-2101.x
https://doi.org/10.1046/j.1365-2141.1997.d01-2101.x