Zobrazeno 1 - 10
of 15
pro vyhledávání: '"L. Thomas Svensson"'
Autor:
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Silencing of STK25, an STE20-type kinase, in human aortic endothelial and smooth muscle cells reduces lipid accumulation and suppresses inflammation and fibrotic pathways, ultimately exerting atheroprotective effects.
Externí odkaz:
https://doaj.org/article/c671ada46a694cea94aa6e66b65dc4a6
Autor:
Emmelie Cansby, Esther Nuñez-Durán, Elin Magnusson, Manoj Amrutkar, Sheri L. Booten, Nagaraj M. Kulkarni, L. Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 597-618 (2019)
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide. Currently, no specific pharmacologic therapy is available for NAFLD/NASH, which has been re
Externí odkaz:
https://doaj.org/article/9be6ef8a91c74cad8b389b66aebc0dd6
Autor:
Mihail Anton, Eivind Almaas, Rui Benfeitas, Sara Benito-Vaquerizo, Lars M. Blank, Andreas Dräger, John M. Hancock, Cheewin Kittikunapong, Matthias König, Feiran Li, Ulf W. Liebal, Hongzhong Lu, Hongwu Ma, Radhakrishnan Mahadevan, Adil Mardinoglu, Jens Nielsen, Juan Nogales, Marco Pagni, Jason A. Papin, Kiran Raosaheb Patil, Nathan D. Price, Jonathan L. Robinson, Benjamín J. Sánchez, Maria Suarez-Diez, Snorre Sulheim, L. Thomas Svensson, Bas Teusink, Wanwipa Vongsangnak, Hao Wang, Ahmad A. Zeidan, Eduard J. Kerkhoven
The field of metabolic modelling at the genomescale continues to grow with more models being created and curated. This comes with an increasing demand for adopting common principles regarding transparency and versioning, in addition to standardisatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e77452cf0848a5f515f35c925440103
https://doi.org/10.1101/2023.03.21.512712
https://doi.org/10.1101/2023.03.21.512712
Autor:
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Publikováno v:
Communications biology. 5(1)
Recent studies highlight the importance of lipotoxic damage in aortic cells as the major pathogenetic contributor to atherosclerotic disease. Since the STE20-type kinase STK25 has been shown to exacerbate ectopic lipid storage and associated cell inj
Autor:
Jonathan L. Robinson, Jens Nielsen, Eduard J. Kerkhoven, Alex Hedin, L. Thomas Svensson, Lena Hansson, Bernhard O. Palsson, Virinchi Billa, Angelo Limeta, Pierre Etienne Cholley, Mathias Uhlén, Avlant Nilsson, Hao Wang, Adil Mardinoglu, Raphael Ferreira, Iván Domenzain, Mihail Anton, Daniel Cook, Pınar Kocabaş, Johan Gustafsson
Publikováno v:
Robinson, J L, Kocabaş, P, Wang, H, Cholley, P E, Cook, D, Nilsson, A, Anton, M, Ferreira, R, Domenzain, I, Billa, V, Limeta, A, Hedin, A, Gustafsson, J, Kerkhoven, E J, Svensson, L T, Palsson, B O, Mardinoglu, A, Hansson, L, Uhlén, M & Nielsen, J 2020, ' An atlas of human metabolism ', Science Signaling, vol. 13, no. 624, eaaz1482 . https://doi.org/10.1126/scisignal.aaz1482
Science signaling, vol 13, iss 624
Sci Signal
Science Signaling
Science signaling, vol 13, iss 624
Sci Signal
Science Signaling
Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model
Autor:
Sofia Martinsson, Mårten Persson, Margit Mahlapuu, Mattias Ormestad, Kerstin Lindgren, L. Thomas Svensson
Publikováno v:
FEBS Journal. 274:2887-2896
The AMP-activated protein kinase is an evolutionarily conserved heterotrimer that is important for metabolic sensing in all eukaryotes. The muscle-specific isoform of the regulatory γ-subunit of the kinase, AMP-activated protein kinase γ3, has a ke
Publikováno v:
The FASEB Journal. 20:1855-1864
The maintenance of cellular levels of free fatty acids and acyl-CoAs, the activated form of free fatty acids, is extremely important, as imbalances in lipid metabolism have serious consequences for human health. Acyl-coenzyme A (CoA) thioesterases (A
Publikováno v:
European Journal of Biochemistry. 239:526-531
In this study we investigated the presence of short-chain acyl-CoA hydrolases in rat liver mitochondria. One acetyl-CoA-hydrolyzing enzyme with a molecular mass of about 48 kDa was purified to apparent homogeneity as judged by SDS/PAGE. Immunoprecipi
Publikováno v:
European Journal of Biochemistry. 230:813-820
We have investigated the effects of peroxisome proliferators on rat liver long-chain acyl-CoA thioesterase activities. Subcellular fractionations of liver homogenates from control, clofibrate- and di(2-ethylhexyl)phthalate-treated rats confirmed earl
Autor:
Kerstin, Lindgren, Mattias, Ormestad, Mårten, Persson, Sofia, Martinsson, L Thomas, Svensson, Margit, Mahlapuu
Publikováno v:
The FEBS journal. 274(11)
The AMP-activated protein kinase is an evolutionarily conserved heterotrimer that is important for metabolic sensing in all eukaryotes. The muscle-specific isoform of the regulatory gamma-subunit of the kinase, AMP-activated protein kinase gamma3, ha