Lead fractions from SAR-derived sea ice divergence during MOSAiC

Autor: L. von Albedyll, S. Hendricks, N. Hutter, D. Murashkin, L. Kaleschke, S. Willmes, L. Thielke, X. Tian-Kunze, G. Spreen, C. Haas

Publikováno v: The Cryosphere, Vol 18, Pp 1259-1285 (2024)

Leads and fractures in sea ice play a crucial role in the heat and gas exchange between the ocean and atmosphere, impacting atmospheric, ecological, and oceanic processes. We estimated lead fractions from high-resolution divergence obtained from sate

Externí odkaz: https://doaj.org/article/8000df2b822b46fcb72eff8a3bb00387

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Autor: David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inf

Externí odkaz: https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Autor: Christian K. Holm, Anne L. Thielke, Rasmus Ottosen, Thomas B. Poulsen, Jinrong Huang, Alice Knudsen, Lydia Bartsch, Siddharth Balachandran, Marie B. Iversen, Camilla G. Nielsen, Victoria H. Gilchrist, Trine H. Mogensen, Huy-Dung Hoang, Alon Schneider Hait, Sofie E. Jørgensen, Line S. Reinert, Suraj Peri, Jan Rehwinkel, Michael Lappe, Charlotte Möller, Michelle M. Thomsen, John Hiscott, Demi van der Horst, Esben B. Svenningsen, Anne Louise Hansen, Yonglun Luo, Jacob Thyrsted, Manja Idorn, Antonio Alcami, Ensieh Farahani, Julia Blay-Cadanet, Martin R. Jakobsen, Bruno Hernáez, Mirjam Schilling, David Olagnier, Søren R. Paludan, Angela Herengt, Tommy Alain

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Olagnier, D, Farahani, E, Thyrsted, J, Blay-Cadanet, J, Herengt, A, Idorn, M, Hait, A, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M, Reinert, L S, Lappe, M, Hoang, H-D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, no. 1, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Olagnier, D P C, Farahani, E, Jensen, J T, Blay Cadanet, J, Herengt, A A P V, Idorn, M, Schneider Hait, A I, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M M, Reinert, L S, Lappe, M, Hoang, H D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications

Versiones preprint disponibles en: http://hdl.handle.net/10261/216920 y http://hdl.handle.net/10261/217161
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c770a0f99e983608245ee2ef5c88b25
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35

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Influenza A Virus Induces LDHA Expression and Lactate Formation to Inhibit Type I IFN and Promote Replication in Primary Human Airway Epithelium

Autor: Andreas Wack, Christian K. Holm, Julia Blay-Cadanet, Stefania Crotta, Jacob Thyrsted, David Olagnier, Karsten Hiller, Jacob Storgaard, Anne Louise Hansen, Anne L. Thielke, Frank Vincenzo de Paoli, Alexander Heinz

Publikováno v: SSRN Electronic Journal.

Pathogenic viruses induce metabolic changes in host cells to secure availability of biomolecules and energy to propagate. Influenza A virus and SARS-CoV-2 both infect the human airway epithelium and are important human pathogens. The metabolic change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed1f2991a659346f2fe7ff74dfece4c5
https://doi.org/10.2139/ssrn.3879081