Zobrazeno 1 - 10
of 37
pro vyhledávání: '"L. T. May"'
Publikováno v:
Annals of the New York Academy of Sciences. 762:120-128
There is increasing evidence that many, perhaps all, cytokines have a soluble form of their receptor in the systemic circulation at all times. There is also evidence that endogenous antibodies to some cytokines, including IL-6, are also found in bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e10a7987c16f33ed37ece9217654c940
https://doi.org/10.1111/j.1749-6632.1995.tb32320.x
https://doi.org/10.1111/j.1749-6632.1995.tb32320.x
Autor:
Kirit Patel, Soldano Ferrone, MacKevin I. Ndubuisi, Dorys Garcia, A Mackiewicz, Pravin B. Sehgal, L T May, Abraham Mittelman
Publikováno v:
Blood. 84:1887-1895
In a phase 1 study of recombinant interleukin-6 (rIL-6) in patients with advanced solid tumors (n = 15), we discovered that the endogenous IL-6 levels, in pretreatment plasma or serum samples, were distributed into two groups. One set of patients (de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a892fa8ce3b9df38fed3074f041e5c82
https://doi.org/10.1182/blood.v84.6.1887.bloodjournal8461887
https://doi.org/10.1182/blood.v84.6.1887.bloodjournal8461887
Publikováno v:
Journal of Biological Chemistry. 267:19698-19704
The biochemical nature of endogenous interleukin-6 (IL-6) as it exists in human serum or plasma was investigated. Serum from a patient following bone marrow (BM) transplantation and fresh plasma samples from patients with epidermolysis bullosa or pso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b76bafcb5cb31d9e04c173dee0f8c9
https://doi.org/10.1016/s0021-9258(18)41831-5
https://doi.org/10.1016/s0021-9258(18)41831-5
Autor:
L T May, Pravin B. Sehgal
Publikováno v:
Biochemical and Biophysical Research Communications. 185:524-530
The cytokine interleukin-6 (IL-6) is the major phosphoprotein secreted by human fibroblasts induced with interleukin-1 alpha (IL-1 alpha). We have determined that Ser54 is the predominant site of phosphorylation on the fibroblast-derived IL-6 polypep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefd40e0730ba2e88ec4e3a660c61697
https://doi.org/10.1016/0006-291x(92)91656-b
https://doi.org/10.1016/0006-291x(92)91656-b
Publikováno v:
The Journal of Immunology. 145:1337-1342
IL-6 is a multifunctional cytokine which is produced by a variety of cells. Therefore it was examined whether anti-CD3-induced T cell activation was associated with the induction of functionally relevant IL-6 in human monocyte accessory cells. Signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2fc05ed8f81c7a94211b7174db43d1b
https://doi.org/10.4049/jimmunol.145.5.1337
https://doi.org/10.4049/jimmunol.145.5.1337
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(1)
Transport of IL-6 in blood is fundamental to the biology of this cytokine. In the present study, IL-6 transport, immunological reactivity, and biological availability were investigated in blood from melanoma patients subjected to different active spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::835ef2b697c45f13b98bae32bbd4a7e2
https://pubmed.ncbi.nlm.nih.gov/9552008
https://pubmed.ncbi.nlm.nih.gov/9552008
Publikováno v:
AIDS research and human retroviruses. 13(10)
Patients infected with human immunodeficiency virus (HIV) frequently have increased production of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), and these cytokines may in turn contribute to the disease pathogenesis. It has been hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9105fdc7ba0816787bc98cc69eb00f82
https://pubmed.ncbi.nlm.nih.gov/9197377
https://pubmed.ncbi.nlm.nih.gov/9197377
Publikováno v:
Annals of the New York Academy of Sciences. 762
There is increasing evidence that many, perhaps all, cytokines have a soluble form of their receptor in the systemic circulation at all times. There is also evidence that endogenous antibodies to some cytokines, including IL-6, are also found in bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46c0a90abe194457b4b4e60bbfc59d9f
https://pubmed.ncbi.nlm.nih.gov/7668523
https://pubmed.ncbi.nlm.nih.gov/7668523
Autor:
L T, May, K, Patel, D, García, M I, Ndubuisi, S, Ferrone, A, Mittelman, A, Mackiewicz, P B, Sehgal
Publikováno v:
Blood. 84(6)
In a phase 1 study of recombinant interleukin-6 (rIL-6) in patients with advanced solid tumors (n = 15), we discovered that the endogenous IL-6 levels, in pretreatment plasma or serum samples, were distributed into two groups. One set of patients (de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::130bcfb35d46510d2a00bdc363f26917
https://pubmed.ncbi.nlm.nih.gov/8080995
https://pubmed.ncbi.nlm.nih.gov/8080995
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 151(6)
In the baboon or the mouse, a stimulus such as LPS, TNF, or IL-1 typically led to a rapid induction of circulating IL-6, the levels peaked by 2 to 3 h and then declined to near-baseline values by 6 to 8 h. Administration to baboons or mice of "neutra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b77dcb919087a9d7d47491361e016cd2
https://pubmed.ncbi.nlm.nih.gov/8376777
https://pubmed.ncbi.nlm.nih.gov/8376777