Zobrazeno 1 - 10 of 13 pro vyhledávání: '"L. T. Bacheler"'
1
The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1′ residues
Autor: Beverly C. Cordova, R. M. Klabe, M. M. Rayner, L. T. Bacheler, Steven P. Seitz, Mona Patel, Susan Erickson-Viitanen
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:823-828
Two series of cyclic ureas modified at the P1/P1′ residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant impr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887c56be7a43fdaec25a94eb9deddde4
https://doi.org/10.1016/s0960-894x(98)00119-x
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2
In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor
Autor: Patrick Y.S. Lam, M. M. Rayner, C. D. Reid, S. Garber, L. T. Bacheler, Dean L. Winslow, Helen Scarnati, M. J. Otto
Publikováno v: Antimicrobial Agents and Chemotherapy. 37:2606-2611
XM323 represents a novel class of potent inhibitors of human immunodeficiency virus (HIV) protease. In vitro studies have shown that inhibition of this enzyme translates into potent inhibition of replication of HIV type 1 (HIV-1) and HIV-2. The inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f94d97f62b4d009a78f3b470966034
https://doi.org/10.1128/aac.37.12.2606
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4
ChemInform Abstract: The Synthesis and Evaluation of Cyclic Ureas as HIV Protease Inhibitors: Modifications of the P1/P1′ Residues
Autor: R. M. Klabe, Beverly C. Cordova, Mona Patel, L. T. Bacheler, M. M. Rayner, Steven P. Seitz, Susan Erickson-Viitanen
Publikováno v: ChemInform. 29
Two series of cyclic ureas modified at the P1/P1′ residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant impr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f4d219c457fb0529be048c482070e05
https://doi.org/10.1002/chin.199830191
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5
Multiple integration sites for Moloney murine leukemia virus in productively infected mouse fibroblasts
Autor: L T Bacheler, H Fan
Publikováno v: Journal of Virology. 30:657-667
The integration sites for viral DNA in cells infected with Moloney murine leukemia virus (M-MuLV) were studied by restriction endonuclease cleavage of cellular DNA followed by electrophoresis in agarose gels, blot transfer to nitrocellulose, and dete
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2871028e11ab47cb8c3669db9bc4f92f
https://doi.org/10.1128/jvi.30.3.657-667.1979
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6
Virus-secific transcription in 3T3 cells transformed by the ts-a mutant of polyoma virus
Autor: L T Bacheler
Publikováno v: Journal of Virology. 22:54-64
Virus-specific RNA transcription has been measured in 3T3 cells transformed by the ts-a mutant of polyoma virus by RNA-excess hybridization to the separated strands of polyoma DNA. In two cloned sublines maintained at 39 degrees C, the nonpermissive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f674c2b485077d82890ec75a747a74
https://doi.org/10.1128/jvi.22.1.54-64.1977
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7
Molecular cloning of unintegrated and a portion of integrated moloney murine leukemia viral DNA in bacteriophage lambda
Autor: M A McKennett, A Berns, M H Lai, H Fan, E C Maandag, Inder M. Verma, R A Bosselman, L T Bacheler, H van der Putten
Publikováno v: Journal of Virology. 36:254-263
A covalently closed circular form of unintegrated viral DNA obtained from NIH 3T3 cells freshly infected with Moloney murine leukemia virus (M-MLV) and a port of the endogenous M-MLV from the BALB/Mo mouse strain have been cloned in bacteriophage lam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23e95315bf223e60cd88eaeb1f3fe88
https://doi.org/10.1128/jvi.36.1.254-263.1980
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8
Integrated Moloney murine leukemia virus DNA studied by using complementary DNA which does not recognize endogenous related sequences
Autor: L T Bacheler, H Fan
Publikováno v: Journal of virology. 33(3)
By preannealing a radioactive, representative Moloney murine leukemia virus (M-MuLV) cDNA with large excesses of AKR 70S viral RNA, an M-MuLV-specific cDNA has been prepared. When hybridized to restriction enzyme fragments of M-MuLV-infected mouse ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd3382d92223d56bc1110b3709bda2e
https://pubmed.ncbi.nlm.nih.gov/6245260
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9
Integration Sites for Moloney Murine Leukemia Virus DNA in Infected Mouse Cells
Autor: H. Fan, L. T. Bacheler
Publikováno v: Modern Trends in Human Leukemia III ISBN: 9783540089995
The integration of viral DNA in mouse cells infected with Moloney murine leukemia virus (M-MuLV) has been studied by the “blotting” technology introduced by Southern (1975). We were interested in determining if there is a single site in the chrom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc7018d4901b6695dd2a92e0d349b5e5
https://doi.org/10.1007/978-3-642-67057-2_73
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