Zobrazeno 1 - 10
of 72
pro vyhledávání: '"L. Strang"'
Autor:
Jerzy Samolej, Diogo Correa Mendonca, Nicole Upfold, Marion McElwee, Mariann Landsberger, Artur Yakimovich, Arvind H. Patel, Blair L. Strang, Jason Mercer
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTWe previously identified the bisbenzimide Hoechst 33342 (H42) as a potent multi-stage inhibitor of the prototypic poxvirus, the vaccinia virus (VACV), and several parapoxviruses. A recent report showed that novel bisbenzimide compounds simila
Externí odkaz:
https://doaj.org/article/a63ca18ee1a7422e8517c64104035fc0
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0292134 (2023)
Transmission of human cytomegalovirus (CMV), from a pregnant woman to her fetus can cause congenital CMV infection, with life-long problems in some infected children. The presence of CMV in an infected individual's bodily fluid is known as shedding.
Externí odkaz:
https://doaj.org/article/c34b6a1cd1cb4068906f3b256aa6d00e
Autor:
Maria Jose Lista, Adam A. Witney, Jenna Nichols, Andrew J. Davison, Harry Wilson, Katie A. Latham, Benjamin J. Ravenhill, Katie Nightingale, Richard J. Stanton, Michael P. Weekes, Stuart J. D. Neil, Chad M. Swanson, Blair L. Strang
Cellular antiviral factors that recognize viral nucleic acid can inhibit virus replication. These include the zinc finger antiviral protein (ZAP), which recognizes high CpG dinucleotide content in viral RNA. Here, we investigated the ability of ZAP t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2370e4a8a1647bc9e67aed073522b40
https://www.repository.cam.ac.uk/handle/1810/346780
https://www.repository.cam.ac.uk/handle/1810/346780
Publikováno v:
Journal of Community Health. 47:604-609
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f50d43a637ca568467e0cbc0f44f956e
https://doi.org/10.1007/s10900-022-01083-7
https://doi.org/10.1007/s10900-022-01083-7
Autor:
Blair L Strang, Christopher R M Asquith, Hanan F Moshrif, Catherine M-K Ho, William J Zuercher, Hassan Al-Ali
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201321 (2018)
Chemogenomic approaches involving highly annotated compound sets and cell based high throughput screening are emerging as a means to identify novel drug targets. We have previously screened a collection of highly characterized kinase inhibitors (Khan
Externí odkaz:
https://doaj.org/article/dad782f96f9748ddba6e6688220794e8
Autor:
Blair L. Strang
Publikováno v:
Journal of General Virology. 103
Antiviral therapy for human cytomegalovirus (HCMV) currently relies upon direct-acting antiviral drugs. However, it is now well known that these drugs have shortcomings, which limit their use. Here I review the identification and investigation of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8545d2a8ba42e971153737bca0f7461c
https://doi.org/10.1099/jgv.0.001795
https://doi.org/10.1099/jgv.0.001795
Publikováno v:
Reviews in medical virology. 32(6)
The detection of human cytomegalovirus (HCMV) in an individual's bodily fluid by culture techniques or through HCMV DNA detection by polymerase chain reaction, is known as HCMV shedding. Human cytomegalovirus shedding has the potential to transmit HC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83acb9b0248eb7c66c846414244b071b
https://pubmed.ncbi.nlm.nih.gov/36196755
https://pubmed.ncbi.nlm.nih.gov/36196755
Autor:
Catherine M K Ho, I'ah Z Donovan-Banfield, Li Tan, Tinghu Zhang, Nathanael S Gray, Blair L Strang
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150339 (2016)
Protein kinase inhibitors can be used as tools to identify proteins and pathways required for virus replication. Using virus replication assays and western blotting we found that the widely used protein kinase inhibitor BAY61-3606 inhibits replicatio
Externí odkaz:
https://doaj.org/article/2e09638a929b49d7bf883c48b409b917
Autor:
Edward Chung Yern Wang, Luis Nobre, Martin Potts, Alice Fletcher-Etherington, Katie Nightingale, Zerbe C, Nicolás M. Suárez, Jenna Nichols, Robin Antrobus, Andrew J. Davison, Jack W. Houghton, Leah M. Hunter, Michael P. Weekes, Richard J. Stanton, Ceri Alan Fielding, Blair L. Strang
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate and adaptive immunity. We have employed two novel, orthogonal multiplexed tandem mass tag-based proteomic screens to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb899ad069b60b78c6c6a6ccf4270619
https://www.repository.cam.ac.uk/handle/1810/331636
https://www.repository.cam.ac.uk/handle/1810/331636
Autor:
Nicole Falci Finardi, HyeongJun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang
Publikováno v:
The Journal of General Virology
The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026b318e923bdbedde7b587309efdee2
https://openaccess.sgul.ac.uk/id/eprint/113794/23/jgv001702.pdf
https://openaccess.sgul.ac.uk/id/eprint/113794/23/jgv001702.pdf