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Infrapopliteal angioplasty using a combined angiosomal reperfusion strategy.

Autor: G K Ambler, A L Stimpson, B G Wardle, D C Bosanquet, U K Hanif, S Germain, C Chick, N Goyal, C P Twine

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172023 (2017)

Infra-popliteal angioplasty continues to be widely performed with minimal evidence to guide practice. Endovascular device selection is contentious and there is even uncertainty over which artery to treat for optimum reperfusion. Direct reperfusion (D

Externí odkaz: https://doaj.org/article/0ea0e544c3f94243b2bc7bfd65f1d4bf

Glucocorticoid treatment in patients with newly diagnosed immune thrombocytopenia switches CD14 ++CD16 + intermediate monocytes from a pro-inflammatory to an anti-inflammatory phenotype

Autor: Lauren P Schewitz-Bowers, Lauren V Jones, Madeleine L. Stimpson, Richard W J Lee, Philippa J P Lait, Charlotte Bradbury, Ashwin Dhanda, Emily L Williams

Publikováno v: Williams, E L, Stimpson, M L, Lait, P J P, Schewitz-Bowers, L P, Jones, L, Dhanda, A, Lee, R W J & Bradbury, C A 2021, ' Glucocorticoid treatment in patients with newly diagnosed immune thrombocytopenia switches CD14 ++ CD16 + intermediate monocytes from a pro-inflammatory to an anti-inflammatory phenotype ', British Journal of Haematology, vol. 192, no. 2, pp. 375-384 . https://doi.org/10.1111/bjh.17205

Immune thrombocytopenia (ITP) is thought to result from an aberrant adaptive autoimmune response, involving autoantibodies, B and T lymphocytes, directed at platelets and megakaryocytes. Previous reports have demonstrated skewed CD4+ T-helper subset

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2635c3cb930bb56a6c42af92855d3863
https://hdl.handle.net/1983/d46dbc2d-4b89-4e00-82e9-f705bf0fc6ab

IL-10 and IL-17 Expression by CD4+ T Cells is Altered in Corticosteroid Refractory Immune Thrombocytopenia (ITP)

Autor: Charlotte Bradbury, Richard W J Lee, Madeleine L. Stimpson, Philippa J P Lait, Emily L Williams, Kimberley Thirlwall, Lauren P Schewitz-Bowers

Publikováno v: Stimpson, M L, Lait, P J P, Schewitz-Bowers, L P, Williams, E L, Thirlwall, K, Lee, R W J & Bradbury, C A 2020, ' IL-10 and IL-17 Expression by CD4+ T Cells is Altered in Corticosteroid Refractory Immune Thrombocytopenia (ITP) ', Journal of Thrombosis and Haemostasis, vol. 18, no. 10, pp. 2712-2720 . https://doi.org/10.1111/jth.14970

BackgroundCorticosteroids remain the first line treatment for patients with Immune Thrombocytopenia (ITP). However, 20-30% of patients do not respond to treatment at tolerable doses. This variation in corticosteroid efficacy is replicated in other au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd46828679ed3bf7bcee68b7c75f6623
https://hdl.handle.net/1983/75cd5a8e-f347-47f2-880f-9240b11377a3

IL-10 and IL-17 expression by CD4

Autor: Madeleine L, Stimpson, Philippa J P, Lait, Lauren P, Schewitz-Bowers, Emily L, Williams, Kimberley F, Thirlwall, Richard W J, Lee, Charlotte A, Bradbury

Publikováno v: Journal of thrombosis and haemostasis : JTHREFERENCES. 18(10)

Corticosteroids remain the first-line treatment for patients with immune thrombocytopenia (ITP). However, 20% to 30% of patients do not respond to treatment at tolerable doses. This variation in corticosteroid efficacy is replicated in other autoimmu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c13b1e08b5d72d413486ac4d9c23e62
https://pubmed.ncbi.nlm.nih.gov/32574429