Výsledky vyhledávání - "L. Steven Hollis"

Bioactivation of Isothiazoles: Minimizing the Risk of Potential Toxicity in Drug Discovery

Autor: Min-Hwa Jasmine Lin, Zhiyang Zhao, Jingzhou Liu, L. Steven Hollis, Adria E. Colletti, Yohannes Teffera, Deborah Choquette

Publikováno v: Chemical Research in Toxicology. 23:1743-1752

Compound 1, (7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine) is a potent, selective inhibitor of c-Met (mesenchymal-epithelial transition factor), a receptor tyrosine kinase that is oft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f29b2a22234a1f810d35602747db846
https://doi.org/10.1021/tx100208k

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Chemical Reactivity of Methoxy 4-O-Aryl Quinolines: Identification of Glutathione Displacement Products in Vitro and in Vivo

Autor: Harmange Jean-Christophe, Brian K. Albrecht, Alessandro Boezio, Jingzhou Liu, Zhiyang Zhao, L. Steven Hollis, Yohannes Teffera, Adria E. Colletti

Publikováno v: Chemical Research in Toxicology. 21:2216-2222

AMG 458 {1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide} is a potent, selective inhibitor of c-Met, a receptor tyrosine kinase that is often deregulated in canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4594588c1a0890f82d0cca7beff6b3b
https://doi.org/10.1021/tx800307n

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ChemInform Abstract: Synthesis of 4-Substituted Phthalazin-1(2H)-ones from 2-Acylbenzoic Acids: Controlling Hydrazine in a Pharmaceutical Intermediate Through PAT-Guided Process Development

Autor: L. Steven Hollis, Melody L. Mak-Jurkauskas, Matthew M. Bio, Karl B. Hansen, Kelly A. Nadeau, Andrew M. Clausen, Steven M. Mennen

Publikováno v: ChemInform. 46

A simple one-pot, two-step process for the conversion of 2-acylbenzoic acids to phthalazin-1(2H)-ones was developed. A robust process was required that delivered the final isolated solid with consistently low levels of residual hydrazine, for further

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5564cbf6b76b6da000409f6d8db47f8a
https://doi.org/10.1002/chin.201547178

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An Efficient, Stereoselective Synthesis of the Hydroxyethylene Dipeptide Isostere Core for the HIV Protease Inhibitor A-792611

Autor: Rodger F. Henry, Yu-Ming Pu, Weifeng Wang, L. Steven Hollis, Ian Marsden, Brian J. Kotecki, Seble Wagaw, Kenneth M. Engstrom

Publikováno v: The Journal of Organic Chemistry. 71:5369-5372

A stereoselective synthesis of the hydroxyethylene dipeptide isostere 1 is described. The route employs a substrate-directed kinetic protonation of an alpha/gamma-substituted lactone to afford the desired stereochemistry. A method for converting the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0760496819e9a76c5e14dbd8a54ded33
https://doi.org/10.1021/jo060737s

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Formation, isolation and characterization of an AB-biaryl atropisomer of oritavancin

Autor: Eric W. Kristensen, Eric J. Stoner, Gregory M. Brill, Alan Christesen, Casey Chun Zhou, Kent D. Stewart, Edmund D. Matayoshi, Steven J. Wittenberger, L. Steven Hollis, Ronald R. Rasmussen

Publikováno v: Tetrahedron. 60:10611-10618

Oritavancin is a semi-synthetic glycopeptide antibiotic which is structurally related to vancomycin. When oritavancin bisphosphate is dried in vacuo with heat, a new compound forms. This new compound is stable only in the solid state and reverts to o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2095a1b5434e682347c40cb775e4e17
https://doi.org/10.1016/j.tet.2004.09.019

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Gender effects on rat metabolism of AMG 900, an orally available small molecule aurora kinase inhibitor

Autor: Laurie B. Schenkel, Min-Hwa Jasmine Lin, L. Steven Hollis, Zhiyang Zhao, Loren Berry, Daniel Waldon

Publikováno v: Drug metabolism letters. 5(4)

AMG 900 is an orally available small molecule that is highly potent and selective as a pan-aurora kinase inhibitor. AMG 900 is currently undergoing phase 1 clinical evaluation in patients with advanced solid tumors. The metabolism of AMG 900 was inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f75b72c0d1242e9aefad88f94aba2a
https://pubmed.ncbi.nlm.nih.gov/22022868

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Catalytic asymmetric hydrogenation of β-ketoesters using new BINAP complexes of ruthenium

Autor: Jeffrey B. Hoke, Eric W. Stern, L. Steven Hollis

Publikováno v: Journal of Organometallic Chemistry. 455:193-196

Two new, air-stable BINAP complexes of ruthenium(II), (RCp)Ru(S-(−)-BINAP)Cl (R=1cr; H, CH3) have been prepared in good yield from the reaction of (RCp)Ru(PPh3)2Cl with S-(−)-BINAP in refluxing toluene. The structure of the methylcyclopentadienyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a060e27b0df28c7f829d616b42774ab1
https://doi.org/10.1016/0022-328x(93)80398-u

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Isolation and identification of a novel impurity of erythromycin A 9-oxime desosaminehydrazinium salt

Autor: L. Steven Hollis, Casey Chun Zhou, Kelley L. Ford, Xiaomei Huang

Publikováno v: The Journal of antibiotics. 58(8)

In the manufacturing process for Biaxin® (clarithromycin), erythromycin-A oxime, an intermediate, is obtained in high yield, when erythromycin-A is treated with hydroxylamine/isopropyl alcohol in the presence of acetic acid. An unusual impurity, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe48261a7b1976d6a9703591dc3ab77
https://pubmed.ncbi.nlm.nih.gov/16266129

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