Zobrazeno 1 - 10
of 310
pro vyhledávání: '"L. Smeets"'
Autor:
Emma J. Kooistra, Kilian Dahm, Antonius E. van Herwaarden, Jelle Gerretsen, Melanie Nuesch Germano, Karoline Mauer, Ruben L. Smeets, Sjef van der Velde, Maarten J. W. van den Berg, Johannes G. van der Hoeven, Anna C. Aschenbrenner, Joachim L. Schultze, Thomas Ulas, Matthijs Kox, Peter Pickkers
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Coronavirus disease 2019 (COVID-19) patients can develop pulmonary fibrosis (PF), which is associated with impaired outcome. We assessed specific leukocytic transcriptome profiles associated with PF and the influence of early dexa
Externí odkaz:
https://doaj.org/article/ef13ccb0f61845e09a7992f819acbd38
Autor:
Demy A. C. van denHaak, Leila‐Sophie Otten, Hans J. P. M. Koenen, Ruben L. Smeets, Berber Piet, Peter Pickkers, Matthijs Kox, Rob ter Heine
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 6, Pp 978-986 (2023)
Abstract A substantial part of critically ill patients suffer from sepsis‐induced immunosuppression. Reversal of immunosuppression through PD‐1 checkpoint inhibition has been proposed as a treatment strategy to overcome immunosuppression in these
Externí odkaz:
https://doaj.org/article/bb884040f1e74e3499a2afb8eaacaa74
Autor:
Anne Hebert, Annet Simons, Janneke HM Schuurs-Hoeijmakers, Hans JPM Koenen, Evelien Zonneveld-Huijssoon, Stefanie SV Henriet, Ellen JH Schatorjé, Esther PAH Hoppenreijs, Erika KSM Leenders, Etienne JM Janssen, Gijs WE Santen, Sonja A de Munnik, Simon V van Reijmersdal, Esther van Rijssen, Simone Kersten, Mihai G Netea, Ruben L Smeets, Frank L van de Veerdonk, Alexander Hoischen, Caspar I van der Made
Publikováno v:
eLife, Vol 11 (2022)
Background: De novo variants (DNVs) are currently not routinely evaluated as part of diagnostic whole exome sequencing (WES) analysis in patients with suspected inborn errors of immunity (IEI). Methods: This study explored the potential added value o
Externí odkaz:
https://doaj.org/article/1943927502a7424bb65899a7d0d2b45e
Autor:
Nori J. L. Smeets, Ruud J. R. Eijk, Saskia N. de Wildt, Charlotte M. H. H. T. Bootsma-Robroeks
Publikováno v:
BMC Pediatrics, Vol 21, Iss 1, Pp 1-5 (2021)
Abstract Background Alemtuzumab is a T cell depleting antibody agent used as induction immunosuppressant therapy in solid organ transplant recipients. In addition, it is being increasingly used to treat severe or glucocorticoid-resistant graft reject
Externí odkaz:
https://doaj.org/article/8618f3b5bdda44f28bed52a5a52d5e77
Autor:
Wynand Alkema, Hans Koenen, Brigit E. Kersten, Charlotte Kaffa, Jacqueline W. B. Dinnissen, Jan G. M. C. Damoiseaux, Irma Joosten, Sophie Driessen-Diks, Renate G. van der Molen, Madelon C. Vonk, Ruben L. Smeets
Publikováno v:
Autoimmunity, Vol 54, Iss 3, Pp 148-155 (2021)
Objectives Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays. However, sta
Externí odkaz:
https://doaj.org/article/4eb648673e614447a7e7837241da4312
Publikováno v:
Critical Care Research and Practice, Vol 2022 (2022)
Background. Regarding sustainability in the intensive care unit (ICU), there is increasing interest in reducing material waste and avoiding unnecessary procedures. Therapeutic drug monitoring (TDM) of vancomycin, using a dedicated tube, is standard c
Externí odkaz:
https://doaj.org/article/b70aa91530374213bfa71a17221d40c4
Publikováno v:
Journal of Translational Autoimmunity, Vol 5, Iss , Pp 100141- (2022)
The ACR/EULAR classification criteria for systemic sclerosis (SSc) entail three autoantibodies: anti-centromere antibodies (ACA), anti-topoisomerase I antibodies (ATA), and anti-RNA-polymerase III antibodies (ARA). The importance of ACA and ATA in th
Externí odkaz:
https://doaj.org/article/1363b5df3ff04f34a53686bb495fedaf
Autor:
Anne T. M. Dittrich, Nori J. L. Smeets, Emma F. M. de Jong, Juliët L. Kämink, Yvet Kroeze, Jos M. Th. Draaisma, Eugène P. van Puijenbroek, D. Maroeska W. M. te Loo
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1148 (2022)
For drug safety in pediatric patients, knowledge about adverse drug reactions (ADRs) is essential to balance benefits and risks, especially because of the high incidence of off-label drug use. However, underreporting of ADRs is a serious problem, lea
Externí odkaz:
https://doaj.org/article/148aef8c56994023940649287268e2a6
Autor:
Paulo C. M. Urbano, Xuehui He, Bennie van Heeswijk, Omar P. S. Filho, Henk Tijssen, Ruben L. Smeets, Irma Joosten, Hans J. P. M. Koenen
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Maintenance of regulatory T cells CD4+CD25highFOXP3+ (Treg) stability is vital for proper Treg function and controlling the immune equilibrium. Treg cells are heterogeneous and can reveal plasticity, exemplified by their potential to express IL-17A.
Externí odkaz:
https://doaj.org/article/27a93538dfc1423a88e93180c95c6d86
Autor:
Nori J. L. Smeets, Lieke P. M. Raaijmakers, Tjitske M. van der Zanden, Christoph Male, Saskia N. de Wildt
Publikováno v:
British Journal of Clinical Pharmacology. Wiley-Blackwell Publishing Ltd
Introduction: Off-label drug use in the paediatric population is common, and the lack of high-quality efficacy studies poses patients at risk for failing pharmacotherapy. Next to efficacy studies, pharmacokinetic (PK) studies are increasingly used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21bb18e66dd8560cc012a5dea994f53
https://doi.org/10.1111/bcp.15781
https://doi.org/10.1111/bcp.15781