POS0402 CLONALLY EXPANDED CD38hi CYTOTOXIC CD8 T CELLS DEFINE THE T CELL INFILTRATE IN CHECKPOINT INHIBITOR-ASSOCIATED ARTHRITIS

Autor: R. Wang, A. Singaraju, K. E. Marks, L. Shakib, G. Dunlap, A. Cunningham-Bussel, S. R. Greisen, L. Chen, A. Tirpack, M. Fein, D. Todd, L. Macfarlane, S. Goodman, E. Dicarlo, E. Massarotti, J. Sparks, O. P. Hamnvik, L. Min, A. H. Jonsson, M. Brenner, K. K. Chan, A. Bass, L. Donlin, D. Rao

Publikováno v: Annals of the Rheumatic Diseases. 81:457.1-457

BackgroundImmune checkpoint inhibitor (ICI) therapies that promote T cell activation have improved outcomes for advanced malignancies yet can also elicit harmful autoimmune reactions. The T cell mechanisms mediating these iatrogenic autoimmune events

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccfaca4e5fd8665de4296db6a35d53e2
https://doi.org/10.1136/annrheumdis-2022-eular.3779

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IFN- γ and TNF- α drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.

Autor: Zhang F; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, MA 02115, USA., Mears JR; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, MA 02115, USA., Shakib L; Graduate Program in Physiology, Biophysics and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Beynor JI; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, MA 02115, USA., Shanaj S; Arthritis and Tissue Degeneration, Hospital for Special Surgery, New York, NY, USA., Korsunsky I; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, MA 02115, USA., Nathan A; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, MA 02115, USA., Donlin LT; Graduate Program in Physiology, Biophysics and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.; Arthritis and Tissue Degeneration, Hospital for Special Surgery, New York, NY, USA., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, MA 02115, USA.; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Aug 05. Date of Electronic Publication: 2020 Aug 05.