Predictors and implications of renal injury after CD19 chimeric antigen receptor T-cell therapy

Autor: Alexander P. Boardman, Victoria Gutgarts, Jessica Flynn, Sean M. Devlin, Adam Goldman, Ana Alarcon Tomas, Joshua A. Fein, John B. Slingerland, Allison Parascondola, Richard J. Lin, Michael Scordo, Parastoo B. Dahi, Sergio Giralt, M. Lia Palomba, Gilles Salles, Karthik Nath, Moneeza Walji, Magdalena Corona, Jae H. Park, Gunjan L. Shah, Miguel-Angel Perales, Insara Jaffer-Sathick, Roni Shouval

Publikováno v: Haematologica, Vol 999, Iss 1 (2024)

Chimeric Antigen Receptor (CAR) T cells targeting CD19 induce durable remissions in patients with relapsed or refractory non-Hodgkin lymphoma (NHL), but many patients experience treatmentrelated toxicity. Cytokine release syndrome and immune effector

Externí odkaz: https://doaj.org/article/ea14faf0d5654d7e85d711bcd95f0978

Favipiravir in patients hospitalised with COVID-19 (PIONEER trial): a multicentre, open-label, phase 3, randomised controlled trial of early intervention versus standard care

Autor: Pallav L Shah, Christopher M Orton, Beatriz Grinsztejn, Gavin C Donaldson, Brenda Crabtree Ramírez, James Tonkin, Breno R Santos, Sandra W Cardoso, Andrew I Ritchie, Francesca Conway, Maria P D Riberio, Dexter J Wiseman, Anand Tana, Bavithra Vijayakumar, Cielito Caneja, Craig Leaper, Bobby Mann, Anda Samson, Pankaj K Bhavsar, Marta Boffito, Mark R Johnson, Anton Pozniak, Michael Pelly, Damon Foster, Nadia Shabbir, Simon Connolly, Andrea Cartier, Sajjida Jaffer, Carmen Winpenny, Doris Daby, Samuel Pepper, Christine Adamson, Jamie Carungcong, Kribashnie Nundlall, Serge Fedele, Pardina Samson-Fessale, Alexandra Schoolmeesters, Laura Gomes de Almeida Martins, Rhian Bull, Patricia Correia Da Costa, Carina Bautista, Maria Eleanor Flores, Shameera Maheswaran, Lester Macabodbod, Rosalie Houseman, Marie-Louise Svensson, Amrinder Sayan, Carrie Fung, Justin Garner, Dilys Lai, Mark Nelson, Luke Moore, Shewta Gidwani, Gary Davies, Beatrice Ouma, Clovis Salinos, Jad Salha, Redasaad Yassein, Abdul Abbasi, Metod Oblak, Angelica Steward, Mini Thankachen, Amy Barker, Candida Fernandes, Veronica Beatriz, Leah Flores, Alfredo Soler-Carracedo, Alessandra Rocca, Carmela Martella, Charlotte Lloyd, Ciara Nolan, Latoya Horsford, Laura Martins, Lervina Thomas, Mark Winstanley, Miriam Bourke, Nicholas Branch, Orhan Orhan, Richard Morton, Sangeetha Saunder, Shashank Patil, Stephen Hughes, Wu Zhe, Ashley De Leon, Ayaan Farah, Grace Rya, Katrin Alizadeh, Kirsty Leong, Laure Trepte, Nupur Goel, Patrick McGown, Ursula Kirwan, Tamiris Vilela Baião, Luana Marins, Sandro Nazer, Raquel Malaguthi de Souza, Marcella Feitosa, Flavia Lessa, Elizabeth Silva de Magalhães, Jamile Costenaro, Rita de Cassia Alves Lira, Ana Carolina, Andréa Cauduro de Castro, Andre Machado Da Silva, Dimas Kliemann, Rita De Cassia Alves Lira, Gemma Walker, Donna Norton, Vicki Lowthorpe, Monica Ivan, Patrick Lillie, Nicholas Easom, Juan Sierra Madero, Álvaro López Iñiguez, Guadalupe Patricia Muñuzuri Nájera, Claudia Paola Alarcón Murra, Audelia Alanis Vega, Teresa Muñoz Trejo, Olivia Pérez Rodríguez

Publikováno v: The Lancet Respiratory Medicine. 11:415-424

COVID-19 has overwhelmed health services globally. Oral antiviral therapies are licensed worldwide, but indications and efficacy rates vary. We aimed to evaluate the safety and efficacy of oral favipiravir in patients hospitalised with COVID-19.We co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f0e6ef99a6e8cee9a438b2282c5402
https://doi.org/10.1016/s2213-2600(22)00412-x

Open-label pilot study of romiplostim for thrombocytopenia after autologous hematopoietic cell transplantation

Autor: Michael Scordo, Leah J. Gilbert, Danielle M. Hanley, Jessica R. Flynn, Sean M. Devlin, Linh K. Nguyen, Josel D. Ruiz, Gunjan L. Shah, Craig S. Sauter, David J. Chung, Heather J. Landau, Oscar B. Lahoud, Richard J. Lin, Parastoo B. Dahi, Miguel-Angel Perales, Sergio A. Giralt, Gerald A. Soff

Publikováno v: Blood Advances. 7:1536-1544

There are no standard treatments to prevent or hasten the recovery from severe conditioning-regimen–induced thrombocytopenia occurring after autologous hematopoietic cell transplantation (auto-HCT). We conducted an open-label, single-arm pilot stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e244dffe40a0b1da09124d3c7ed78c3
https://doi.org/10.1182/bloodadvances.2022007838

Examining the psychobiological response to acute social stress across clinical stages and symptom trajectories in the early psychosis continuum

Autor: Jai L. Shah, Vincent Paquin, Sarah V. McIlwaine, Ashok K. Malla, Ridha Joober, Marita Pruessner

Publikováno v: Development and Psychopathology. :1-13

The stress-vulnerability model has been repeatedly highlighted in relation to the risk, onset and course of psychosis, and has been independently studied in clinical high-risk (CHR) and first-episode psychosis (FEP) populations. Notable in this liter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81c2f1baaf328df2b435550dd8699083
https://doi.org/10.1017/s0954579423000056

Transsyndromic trajectories from pre-onset self-harm and subthreshold psychosis to the first episode of psychosis: A longitudinal study

Autor: Vincent Paquin, Ashok K. Malla, Srividya N. Iyer, Martin Lepage, Ridha Joober, Jai L. Shah

Publikováno v: Journal of Psychopathology and Clinical Science. 132:198-208

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69fcaaed3c5483191a8e74aae7917bb0
https://doi.org/10.1037/abn0000806