Integrin-mediated interactions with a laminin-presenting substrate modulate biosynthesis and phenotypic expression for cells of the human nucleus pulposus

Autor: J Speer, M Barcellona, L Jing, B Liu, M Lu, M Kelly, J Buchowski, L Zebala, S Luhmann, M Gupta, L Setton

Publikováno v: European Cells & Materials, Vol 41, Pp 793-810 (2021)

With aging and pathology, cells of the nucleus pulposus (NP) de-differentiate towards a fibroblast-like phenotype, a change that contributes to degeneration of the intervertebral disc (IVD). Laminin isoforms are a component of the NP extracellular ma

Externí odkaz: https://doaj.org/article/4c6d9293e99c4dab9b151abff5f4d711

Canadian Spine Society abstracts1.1.01 Supraspinal modulation of gait abnormalities associated with noncompressive radiculopathy may be mediated by altered neurotransmitter sensitivity1.1.02 Neuroprotective effects of the sodium-glutamate blocker riluzole in the setting of experimental chronic spondylotic myelopathy1.1.03 The effect of timing to decompression in cauda equina syndrome using a rat model1.2.04 Intraoperative waste in spine surgery: incidence, cost and effectiveness of an educational program1.2.05 Looking beyond the clinical box: the health services impact of surgical adverse events1.2.06 Brace versus no brace for the treatment of thoracolumbar burst fractures without neurologic injury: a multicentre prospective randomized controlled trial1.2.07 Adverse event rates in surgically treated spine injuries without neurologic deficit1.2.08 Functional and quality of life outcomes in geriatric patients with type II odontoid fracture: 1-year results from the AOSpine North America Multi-Center Prospective GOF Study1.3.09 National US practices in pediatric spinal fusion: in-hospital complications, length of stay, mortality, costs and BMP utilization1.3.10 Current trends in the surgical treatment of adolescent idiopathic scoliosis in Canada1.3.11 Sagittal spinopelvic parameters help predict the risk of proximal junctional kyphosis for children treated with posterior distraction-based implants1.4.12 Correlations between changes in surface topography and changes in radiograph measurements from before to 6 months after surgery in adolescents with idiopathic scoliosis1.4.13 High upper instrumented vertebra (UIV) sagittal angle is associated with UIV fracture in adult deformity corrections1.4.14 Correction of adult idiopathic scoliosis using intraoperative skeletal traction1.5.01 Cauda equina: using management protocols to reduce delays in diagnosis1.5.02 Predicting the need for tracheostomy in patients with acute traumatic spinal cord injury1.5.03 A novel animal model of cervical spondylotic myelopathy: an opportunity to identify new therapeutic targets1.5.04 A review of preference-based measures of health-related quality of life in spinal cord injury research1.5.05 Predicting postoperative neuropathic pain following surgery involving nerve root manipulation based on intraoperative electromyographic activity1.5.06 Detecting positional injuries in prone spinal surgery1.5.07 Percutaneous thoracolumbar stabilization for trauma: surgical morbidity, clinical outcomes and revision surgery1.5.08 Systemic inflammatory response syndrome in spinal cord injury patients: Does its presence at admission affect patient outcomes?2.1.15 One hundred years of spine surgery — a review of the evolution of our craft and practice in the spine surgical century [presentation]2.1.16 Prevalence of preoperative MRI findings of adjacent segment disc degeneration in patients undergoing anterior cervical discectomy and fusion2.1.17 Adverse event rates of surgically treated cervical spondylopathic myelopathy2.1.18 Morphometricand dynamic changes in the cervical spine following anterior cervical discectomy and fusion and cervical disc arthroplasty2.1.19 Is surgery for cervical spondylotic myelopathy cost-effective? A cost–utility analysis based on data from the AO Spine North American Prospective Multicentre CSM Study2.2.20 Cost–utility of lumbar decompression with or without fusion for patients with symptomatic degenerative lumbar spondylolisthesis (DLS)2.2.21 Minimally invasive surgery lumbar fusion for low-grade isthmic and degenerative spondylolisthesis: 2- to 5-year follow-up2.2.22 Results and complications of posterior-only reduction and fusion for high-grade spondylolisthesis2.3.23 Fusion versus no fusion in patients with central lumbar spinal stenosis and foraminal stenosis undergoing decompression surgery: comparison of outcomes at baseline and follow-up2.3.24 Two-year results of interspinous spacers (DIAM) as an alternative to arthrodesis for lumbar degenerative disorders2.3.25 Treatment of herniated lumbar disc by sequestrectomy or conventional discectomy2.4.26 No sustained benefit of continuous epidural analgesia for minimally invasive lumbar fusion: a randomized double-blinded placebo controlled study2.4.27 Evidence and current practice in the radiologic assessment of lumbar spine fusion2.4.28 Wiltse versus midline approach for decompression and fusion of the lumbar spine2.5.09 The effect of soft tissue restraints following type II odontoid fractures in the elderly — a biomechanical study2.5.10 Development of an international spinal cord injury (SCI) spinal column injury basic data set2.5.11 Evaluation of instrumentation techniques for a unilateral facet perch and fracture using a validated soft tissue injury model2.5.12 Decreasing neurologic consequences in patients with spinal infection: the testing of a novel diagnostic guideline2.5.13 Prospective analysis of adverse events in surgical treatment of degenerative spondylolisthesis2.5.14 Load transfer characteristics between posterior fusion devices and the lumbar spine under anterior shear loading: an in vitro investigation2.5.15 Preoperative predictive clinical and radiographic factors influencing functional outcome after lumbar discectomy2.5.16 A Thoracolumbar Injury Classification and Severity Score (TLICS) of 4: What should we really do?3.1.29 Adverse events in emergent oncologic spine surgery: a prospective analysis3.1.30 En-bloc resection of primary spinal and paraspinal tumours with critical vascular involvement3.1.31 The treatment impact of minocycline on quantitative MRI in acute spinal cord injury3.1.32 Benefit of minocycline in spinal cord injury — results of a double-blind randomized placebo-controlled study3.2.33 Improvement of magnetic resonance imaging correlation with unilateral motor or sensory deficits using diffusion tensor imaging3.2.34 Comparing care delivery for acute traumatic spinal cord injury in 2 Canadian centres: How do the processes of care differ?3.2.35 Improving access to early surgery: a comparison of 2 centres3.3.36 The effects of early surgical decompression on motor recovery after traumatic spinal cord injury: results of a Canadian multicentre study3.3.37 A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors3.3.38 Effect of motor score on adverse events and quality of life in patients with traumatic spinal cord injury3.4.39 The impact of facet dislocation on neurologic recovery after cervical spinal cord injury: an analysis of data on 325 patients from the Surgical Trial in Acute Spinal Cord Injury Study (STASCIS)3.4.40 Toward a more precise understanding of the epidemiology of traumatic spinal cord injury in Canada3.4.41 Access to care (ACT) for traumatic SCI: a survey of acute Canadian spine centres3.4.42 Use of the Spine Adverse Events Severity (SAVES) instrument for traumatic spinal cord injury3.5.17 Does the type of distraction-based growing system for early onset scoliosis affect postoperative sagittal alignment?3.5.18 Comparison of radiation exposure during thoracolumbar fusion using fluoroscopic guidance versus anatomic placement of pedicle screws3.5.19 Skeletal traction for intraoperative reduction in adolescent idiopathic scoliosis3.5.20 Utility of intraoperative cone-beam computed tomography (O-ARM) and stereotactic navigation in acute spinal trauma surgery3.5.21 Use of a central compression rod to reduce thoracic level spinal osteotomies3.5.22 ICD-10 coding accuracy for spinal cord injured patients3.5.23 Feasibility of patient recruitment in acute SCI trials3.5.24 Treatment of adult degenerative scoliosis with DLIF approaches

Autor: E. Huang, B. Kwon, A. Kim, C. Lin, R. Schouten, N. Egge, R. El-Hawary, J. Street, V.K. Noonan, R. Lewis, J. Wilson, A. Santos, K. Rajamanickam, S. Casha, Y. Zhang, A. Ranganathan, N. Dea, A. Quateen, D. Arora, A. Melnyk, A. Kelly, S. Ferrara, M. Nadeau, M. McCabe, Z. Wang, C. Goldstein, S. Choi, M. Shamji, E. Abraham, J. Gill, S.A. Harris, S. Kim, M. Fehlings, A. Fichadi, D. Hartig, K. Lundine, Drew Bednar, A. Kesani, N.A Manson, J. Norton, D. Whitehurst, S. Karadimas, C.S. Bailey, S. Jones, A. Dold, M. Hashem, E. Dodwell, A. Simmonds, A. Soroceanu, R.A. Glennie, E. Su Moon, P. Hwang, K. Allen, L. Jing, B. Mata, M. Gabr, W. Richardson, L. Setton, J. Fleming, K. Gurr, S. Bailey, F. Siddiqi, A. Lawendy, D. Sanders, M. Staudt, E. Canacari, E. Brown, A. Robinson, K. McGuire, C. Chrysostoum, Y. Raja Rampersaud, M.F. Dvorak, K.C. Thomas, M.C. Boyd, K.R. Gurr, S.I. Bailey, C.G Fisher, J. Batke, M. Boyd, M. Dvorak, C. Fisher, S. Paquette, A. Vaccaro, J. Chapman, P. Arnold, C. Shaffrey, B. Kopjar, B. Snyder, J. Wright, S. Lewis, R. Zeller, P. Moroz, S. Bacon, P. Jarzem, D. Hedden, J. Howard, P. Sturm, P. Cahill, A. Samdani, M. Vitale, P. Gabos, N. Bodin, C. d’Amato, C. Harris, J. Smith, E. Parent, D. Hill, M. Moreau, J. Mahood, A. Bodrogi, H. Abbas, S. Goldstein, Y. Bronstein, S. Chua, S. Magana, A. Van Houwelingen, E. Halpern, S. Jhaveri, A. Lim, P. Leelapattana, F. Siddiqqi, K. Satkunendrarajah, V. Noonan, S. Bryan, K. Aronyk, R. Fox, A. Nataraj, J. Pugh, R. Elliott, M. McKeon, E.P. Abraham, G. Davis, M. Rogers, M. Staples, G. Quan, R.J. Hurlbert, W.B. Jacobs, S. Duplessis, N. Jha, S. Hewson, E. Massicotte, S. Mortaz, P. Coyte, Y.R. Rampersaud, B. Andrew, H. Modi, D. Roffey, I. Miles, E. Wai, N. Manson, D. Eastwood, R. Elliot, I. Bains, E. Yong, G. Sutherland, V.W.S. Chan, O. Persaud, A. Koshkin, R. Brull, N. Hassan, S. Petis, M. Kowalczuk, B. Petrisor, B. Drew, M. Bhandari, C. DiPaola, S. McLachlin, C. Bailey, C. Dunning, M.G. Fehlings, P. Wing, E. Itshayek, F. Biering-Sorensen, A. Bradi, R. Pokrupa, T. Wen, S. Kingwell, J. Chak, V. Singh, P. Cripton, T. Oxland, Z. Wali, D. Yen, A. Alfllouse, A. Alzahrani, H. Jiang, F. Kortbeek, R. Reddy, R. Rampersaud, J. Hurlbert, W. Yong, D. Zygun, D. McGowan, V.W. Yong, B. Mendis, S. Chakraborty, T. Nguyen, E. Tsai, A. Chen, D. Atkins, D. Tsui, A. Townson, C. Craven, M. Ford, H. Ahn, A. Kiss, J. Harrop, R. Grossman, R. Frankowski, J. Guest, B. Aarabi, A. Cheung, B. Sun, L. Marais, M. Queyranne, D. Fourney, M. Johnson, A. Yee, J. Finkelstein, J. Paquet, S. Parent, S. Christie, J. Lange, A. Lapinsky, P. Connolly, J. Eck, D. Rabin, R. Lee, M. Sofia, J. Shin, K. Tung, R. Ghag, T. Goyal, J. Littlewood, R. Cho, K. Thomas, G. Swamy

Publikováno v: Canadian Journal of Surgery. 55:S35-S58

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b08cb4a21580e691b409c3b1843283a
https://doi.org/10.1503/cjs.012212

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.