Zobrazeno 1 - 10
of 91
pro vyhledávání: '"L. Seeberger"'
Autor:
Kateryna Polishevska, Sandra Kelly, Purushothaman Kuppan, Karen L. Seeberger, Saloni Aggarwal, Joy Paramor, Larry D. Unsworth, Hubert M. Tse, Gregory S. Korbutt, Andrew R. Pepper
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1137 (2023)
Beta cell replacement therapies can restore glycemic control to select individuals living with type 1 diabetes. However, the obligation of lifelong immunosuppression restricts cell therapies from replacing exogenous insulin administration. Encapsulat
Externí odkaz:
https://doaj.org/article/66a636e3137441e39325b8f3f61481b3
Autor:
Karen L Seeberger, Bassem F Salama, Sandra Kelly, Mandy Rosko, Chelsea Castro, Jessica DesAulniers, Gregory S Korbutt
Publikováno v:
Xenotransplantation. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1589470cb45b8c4f440354d1437f4b41
https://doi.org/10.1111/xen.12793
https://doi.org/10.1111/xen.12793
Autor:
Kateryna Polishevska, Osmanmyrat Hojanepesov, Purushothaman Kuppan, Sandra E. Kelly, Gregory S. Korbutt, Karen L. Seeberger, Andrew R. Pepper
Publikováno v:
American Journal of Transplantation. 20:714-725
The broad application of s cell transplantation for type 1 diabetes is hindered by the requisite of lifelong systemic immunosuppression. This study examines the utility of localized islet graft drug delivery to subvert the inflammatory and adaptive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80994f54709b232802face821045282
https://doi.org/10.1111/ajt.15662
https://doi.org/10.1111/ajt.15662
Akademický článek
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Autor:
Karen L. Seeberger, Gregory S. Korbutt, Veronika Kozlovskaya, Eugenia Kharlampieva, Purushothaman Kuppan, Chad S. Hunter, Jessica Kepple, Hubert M. Tse, Jessie Barra
Publikováno v:
XenotransplantationREFERENCES. 28(6)
Background Islet transplantation with neonatal porcine islets (NPIs) is a promising treatment for type 1 diabetes (T1D), but immune rejection poses a major hurdle for clinical use. Innate immune-derived reactive oxygen species (ROS) synthesis can fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bbe5d6ce0e4843c2ab562b829a077e0
https://pubmed.ncbi.nlm.nih.gov/34245064
https://pubmed.ncbi.nlm.nih.gov/34245064
Autor:
Karen L. Seeberger, Shane T. Grey, Stacey N. Walters, Nathan W. Zammit, Jad Zamerli, Leszek Lisowski, Gregory S. Korbutt
Publikováno v:
Xenotransplantation. 28
Background Neonatal porcine islets (NPIs) can restore glucose control in mice, pigs, and non-human primates, representing a potential abundant alternative islet supply for clinical beta cell replacement therapy. However, NPIs are vulnerable to inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8083c87475fa21a521686a27e8724ee2
https://doi.org/10.1111/xen.12669
https://doi.org/10.1111/xen.12669
Autor:
Telford Y Yeung, Karen L Seeberger, Tatsuya Kin, Adetola Adesida, Nadr Jomha, A M James Shapiro, Gregory S Korbutt
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38189 (2012)
Transplantation of human islets is an attractive alternative to daily insulin injections for patients with type 1 diabetes. However, the majority of islet recipients lose graft function within five years. Inflammation is a primary contributor to graf
Externí odkaz:
https://doaj.org/article/974b5a59c0d94d79b03dff9cffcc8aba
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Julie A Hayward, Purushothaman Kuppan, Karen L. Seeberger, Aillette Mulet-Sierra, Cara E Ellis, Bassem Salama, Gregory S. Korbutt, Adetola B Adesida, Tim Y T Lee
Publikováno v:
Diabetes. 66:1312-1321
Mesenchymal stem cells (MSCs) possess immunoregulatory, anti-inflammatory, and proangiogenic properties and, therefore, have the potential to improve islet engraftment and survival. We assessed the effect human bone marrow–derived MSCs have on neon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5218bd8f022bffa9752c027a82262af3
https://doi.org/10.2337/db16-1068
https://doi.org/10.2337/db16-1068
Autor:
Mandy Rosko, Gregory S. Korbutt, Purushothaman Kuppan, Sandra E. Kelly, Adetola B Adesida, Andrew R. Pepper, Karen L. Seeberger
Publikováno v:
Xenotransplantation. 27
BACKGROUND Cell transplantation has been widely recognized as a curative treatment strategy for variety of diseases including type I diabetes (T1D). Broader patient inclusion for this therapeutic option is restricted by a limited supply of healthy hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4282d4ea73633de3bfdc7dcaa304805
https://doi.org/10.1111/xen.12581
https://doi.org/10.1111/xen.12581