Zobrazeno 1 - 10
of 341
pro vyhledávání: '"L. Schueler"'
Autor:
Natalie M. Niemi, Lia R. Serrano, Laura K. Muehlbauer, Catherine E. Balnis, Lianjie Wei, Andrew J. Smith, Keri-Lyn Kozul, Merima Forny, Olivia M. Connor, Edrees H. Rashan, Evgenia Shishkova, Kathryn L. Schueler, Mark P. Keller, Alan D. Attie, Jonathan R. Friedman, Julia K. Pagan, Joshua J. Coon, David J. Pagliarini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant mitochondrial protein phosphorylation, suffer from a range of metabolic defects, a
Externí odkaz:
https://doaj.org/article/d6347c4096ff4f039a05ff1f1aaf0cd0
Autor:
Kelly A. Mitok, Kathryn L. Schueler, Sarah M. King, Joseph Orr, Kathleen A. Ryan, Mark P. Keller, Ronald M. Krauss, Braxton D. Mitchell, Alan R. Shuldiner, Alan D. Attie
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100468- (2023)
Common noncoding variants at the human 1p13.3 locus associated with SORT1 expression are among those most strongly associated with low-density lipoprotein cholesterol (LDL-C) in human genome-wide association studies. However, validation studies in mi
Externí odkaz:
https://doaj.org/article/c1be21f245b04a43b1a714819dee4fd0
Autor:
Tara R. Price, Christopher H. Emfinger, Kathryn L. Schueler, Sarah King, Rebekah Nicholson, Tim Beck, Brian S. Yandell, Scott A. Summers, William L. Holland, Ronald M. Krauss, Mark P. Keller, Alan D. Attie
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100471- (2023)
Despite great progress in understanding lipoprotein physiology, there is still much to be learned about the genetic drivers of lipoprotein abundance, composition, and function. We used ion mobility spectrometry to survey 16 plasma lipoprotein subfrac
Externí odkaz:
https://doaj.org/article/6ad83e9149c14cb19d8e30950906c97d
Autor:
Christopher H Emfinger, Lauren E Clark, Brian Yandell, Kathryn L Schueler, Shane P Simonett, Donnie S Stapleton, Kelly A Mitok, Matthew J Merrins, Mark P Keller, Alan D Attie
Publikováno v:
eLife, Vol 12 (2023)
Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+ into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+ dyna
Externí odkaz:
https://doaj.org/article/de0ff10cf88640b2b8b46a53e15528a6
Autor:
Tara R Price, Donnie S Stapleton, Kathryn L Schueler, Marie K Norris, Brian W Parks, Brian S Yandell, Gary A Churchill, William L Holland, Mark P Keller, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010713 (2023)
We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 whe
Externí odkaz:
https://doaj.org/article/754e612d4ef044c484fffca47c26b6ac
Autor:
Chenyang Dong, Shane P. Simonett, Sunyoung Shin, Donnie S. Stapleton, Kathryn L. Schueler, Gary A. Churchill, Leina Lu, Xiaoxiao Liu, Fulai Jin, Yan Li, Alan D. Attie, Mark P. Keller, Sündüz Keleş
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Genome-wide association studies reveal many non-coding variants associated with complex traits. However, model organism studies largely remain as an untapped resource for unveiling the effector genes of non-coding variants. We develop INFIMA
Externí odkaz:
https://doaj.org/article/47ca5af6b89a420aa3de1a894239c486
Autor:
Christopher H. Emfinger, Eleonora de Klerk, Kathryn L. Schueler, Mary E. Rabaglia, Donnie S. Stapleton, Shane P. Simonett, Kelly A. Mitok, Ziyue Wang, Xinyue Liu, Joao A. Paulo, Qinq Yu, Rebecca L. Cardone, Hannah R. Foster, Sophie L. Lewandowski, José C. Perales, Christina M. Kendziorski, Steven P. Gygi, Richard G. Kibbey, Mark P. Keller, Matthias Hebrok, Matthew J. Merrins, Alan D. Attie
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β cell–specific deletion of Zfp148 (β-Zfp148KO) improves glucose to
Externí odkaz:
https://doaj.org/article/89940b8a0be241239ae78674f9a31df7
Autor:
Natalie M. Niemi, Gary M. Wilson, Katherine A. Overmyer, F.-Nora Vögtle, Lisa Myketin, Danielle C. Lohman, Kathryn L. Schueler, Alan D. Attie, Chris Meisinger, Joshua J. Coon, David J. Pagliarini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The mitochondria houses several phosphatases, but their function is not well characterized. Here, the authors show that mitochondrial phosphatase Pptc7 is important during development for proper mitochondrial function and has a role regulating protei
Externí odkaz:
https://doaj.org/article/0cc3120d036a46b9807f1cae4a084aeb
Autor:
Jee-Hwan Oh, Kathryn L. Schueler, Donnie S. Stapleton, Laura M. Alexander, Chi-Liang Eric Yen, Mark P. Keller, Alan D. Attie, Jan-Peter van Pijkeren
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT The incidence of metabolic syndrome continues to rise globally. In mice, intravenous administration of interleukin-22 (IL-22) ameliorates various disease phenotypes associated with diet-induced metabolic syndrome. In patients, oral treatment
Externí odkaz:
https://doaj.org/article/0f213e589b174cc3ad9814872f2e3b93
Autor:
Julia H. Kreznar, Mark P. Keller, Lindsay L. Traeger, Mary E. Rabaglia, Kathryn L. Schueler, Donald S. Stapleton, Wen Zhao, Eugenio I. Vivas, Brian S. Yandell, Aimee Teo Broman, Bruno Hagenbuch, Alan D. Attie, Federico E. Rey
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1739-1750 (2017)
Genetic variation drives phenotypic diversity and influences the predisposition to metabolic disease. Here, we characterize the metabolic phenotypes of eight genetically distinct inbred mouse strains in response to a high-fat/high-sucrose diet. We fo
Externí odkaz:
https://doaj.org/article/75f19c5e86764906ab8ac7a278e24a66