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Akademický článek

Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease

Autor: V. Rizelio, R.E. Szawka, L.L. Xavier, M. Achaval, P. Rigon, L. Saur, F. Matheussi, A.M. Delattre, J.A. Anselmo-Franci, M. Meneses, A.C. Ferraz

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 43, Iss 1, Pp 85-95 (2010)

The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl-D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the

Externí odkaz: https://doaj.org/article/35bbf9314015474698ce949c73a64ac1

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Akademický článek

The leucine-rich repeats in allelic barley MLA immune receptors define specificity towards sequence-unrelated powdery mildew avirulence effectors with a predicted common RNase-like fold.

Autor: Saskia Bauer, Dongli Yu, Aaron W Lawson, Isabel M L Saur, Lamprinos Frantzeskakis, Barbara Kracher, Elke Logemann, Jijie Chai, Takaki Maekawa, Paul Schulze-Lefert

Publikováno v: PLoS Pathogens, Vol 17, Iss 2, p e1009223 (2021)

Nucleotide-binding domain leucine-rich repeat-containing receptors (NLRs) in plants can detect avirulence (AVR) effectors of pathogenic microbes. The Mildew locus a (Mla) NLR gene has been shown to confer resistance against diverse fungal pathogens i

Externí odkaz: https://doaj.org/article/2b64e97489114b00aa93dcbff7fff272

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Combination of in-vivo proximity labeling and co-immunoprecipitation identifies the host target network of a tumor-inducing effector in the fungal maize pathogen Ustilago maydis

Autor: Wei Shi, Sara C Stolze, Hirofumi Nakagami, Johana C Misas Villamil, Isabel M L Saur, Gunther Doehlemann

Publikováno v: Journal of Experimental Botany.

Plant pathogens secrete effectors, which target host proteins to facilitate infection. The Ustilago maydis effector UmSee1 is required for tumor formation in the leaf during infection of maize. UmSee1 interacts with maize SGT1 and blocks its phosphor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97feb4f81dc14a9e74c46c8c83ed5093
https://doi.org/10.1093/jxb/erad188

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The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase

Publikováno v: Nature Genetics.

To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool1. Isolating these genes facilitates their f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7708e306a82326adea30a5b110297f4c
https://doi.org/10.1038/s41588-023-01402-1

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PO-1090 Late toxicity-related symptoms and fraction dose affect decision regret in HNC patients

Autor: M. Koeksal, L. Saur, C. Dejonckheere, F. Far, S. Strieth, F.A. Giordano

Publikováno v: Radiotherapy and Oncology. 170:S926

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc3d63cb960a90003dcbfbf6a0d5d40e
https://doi.org/10.1016/s0167-8140(22)03054-7

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Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling

Autor: Viera Kovacova, Lisa K. Mahdi, Leïla Brulé Kopp, Menghang Huang, Florence Jacob, Xiaoxiao Zhang, Jane E. Parker, Isabel M. L. Saur, Kay Hofmann, Paul Schulze-Lefert, Ryohei Thomas Nakano, Takaki Maekawa, Dmitry Lapin, James M. Murphy, Jijie Chai

Publikováno v: Cell Host & Microbe
Cell Host & Microbe, 2020, 28 (6), pp.813-824.e6. ⟨10.1016/j.chom.2020.08.012⟩

International audience; HeLo domain-containing mixed lineage kinase domain-like protein (MLKL), a pseudokinase, mediates necroptotic cell death in animals. Here, we report the discovery of a conserved protein family across seed plants that structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf20c6e2dfb00ca1a414aea32c12abb
https://hal.inrae.fr/hal-03220484

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Recognition and defence of plant-infecting fungal pathogens

Autor: Isabel M. L. Saur, Ralph Hückelhoven

Attempted infections of plants with fungi result in diverse outcomes ranging from symptom-less resistance to severe disease and even death of infected plants. The deleterious effect on crop yield have led to intense focus on the cellular and molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e269f0ff11e5197d1eeeec2f0275f11
https://mediatum.ub.tum.de/1586363

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NOD-like receptor-mediated plant immunity: from structure to cell death

Autor: Ralph Panstruga, Isabel M. L. Saur, Paul Schulze-Lefert

Publikováno v: Nature reviews. Immunology. 21(5)

Animal and plant immune systems use intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) to detect pathogens, resulting in the activation of immune responses that are often associated with localized host cell death. Whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654cd5898c23401d51fa60d25f63eea2
https://pubmed.ncbi.nlm.nih.gov/33293618

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