Zobrazeno 1 - 10
of 933
pro vyhledávání: '"L. Samson"'
Autor:
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond KH Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine A O’Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James M Murphy, André L Samson
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1717-1749 (2024)
Abstract Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney, heart and brain. However, precise identification of the ce
Externí odkaz:
https://doaj.org/article/3261c59629e24716b5f237cbc3d2531c
Autor:
Ulla Feldt-Rasmussen, Marek Bolanowski, Shao-Ling Zhang, Yerong Yu, Przemysław Witek, Pramila Kalra, Noppadol Kietsiriroje, Andrea Piacentini, Alberto M. Pedroncelli, Susan L. Samson
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionPasireotide, a somatostatin receptor ligand, is approved for treating acromegaly and Cushing’s disease (CD). Hyperglycemia during treatment can occur because of the drug’s mechanism of action, although treatment discontinuation is rar
Externí odkaz:
https://doaj.org/article/5afcf0fd8e6c4464b10108cdfc674212
Autor:
Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL, the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. Here we show that this substitution confers a gain i
Externí odkaz:
https://doaj.org/article/14198b0aa4ad4e93a3c3095f5a9f9cb4
Autor:
Salim Virani, Mahmoud Al Rifai, Susan L Samson, Aanand D Naik, Elizabeth M Vaughan, Vanessa Schick, Craig A Johnston, Laura Porterfield, Victor J Cardenas,, Zuleica Santiago Delgado
Publikováno v:
BMJ Open, Vol 13, Iss 10 (2023)
Background Recruitment for clinical studies is challenging. To overcome barriers, investigators have previously established call-to-entry rates to assist in planning. However, rates specific to low-income minority populations are needed to account fo
Externí odkaz:
https://doaj.org/article/3f45218ecab9457ab19e386febc8503e
Publikováno v:
Acta Oto-Laryngologica Case Reports, Vol 7, Iss 1, Pp 19-21 (2022)
Esthesioneuroblastoma (ENB) is a rare neuroendocrine malignancy of the olfactory epithelium that infrequently presents with syndrome of inappropriate antidiuretic hormone (SIADH). We discuss the case of a 37-year-old woman with history of primary hyp
Externí odkaz:
https://doaj.org/article/d92ca5f21ebd49629c01bb35c04bc32b
Autor:
Yanxiang Meng, Christopher R. Horne, Andre L. Samson, Laura F. Dagley, Samuel N. Young, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-12 (2022)
Abstract Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3. To mediate necroptosis, RIPK3 must stably interact with
Externí odkaz:
https://doaj.org/article/cbe0b2a830d34eb4ad810da967695163
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
Autor:
Annette V. Jacobsen, Catia L. Pierotti, Kym N. Lowes, Amanda E. Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus J. A. Kersten, André L. Samson, Mark F. van Delft, David C. S. Huang, Hélène Jousset Sabroux, Guillaume Lessene, John Silke, James M. Murphy
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-13 (2022)
Abstract Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed lineage kinase domain-like (MLKL) pseudokinase after its activation by the upstream kinases, receptor interacting p
Externí odkaz:
https://doaj.org/article/f547bcb22fb646c5bc4448de09ec5253
Autor:
Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet. Here, the authors present the crystal structures of the human RIPK3:MLKL complex and hu
Externí odkaz:
https://doaj.org/article/c906a3851c864c11bf414f6e8e863c7b
Autor:
Daniel Frank, Sarah E. Garnish, Jarrod J. Sandow, Ashley Weir, Lin Liu, Elise Clayer, Lizeth Meza, Maryam Rashidi, Simon A. Cobbold, Simon R. Scutts, Marcel Doerflinger, Holly Anderton, Kate E. Lawlor, Najoua Lalaoui, Andrew J. Kueh, Vik Ven Eng, Rebecca L. Ambrose, Marco J. Herold, Andre L. Samson, Rebecca Feltham, James M. Murphy, Gregor Ebert, Jaclyn S. Pearson, James E. Vince
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104632- (2022)
Summary: Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of R
Externí odkaz:
https://doaj.org/article/3caa971ec6024a6691ed27fdce5d0571
Autor:
Luisa F. Figueredo, Andrea L. Martínez, Paola Suarez-Meade, Lina Marenco-Hillembrand, Andrés Felipe Salazar, Daniela Pabon, Juan Guzmán, Renata Murguiondo-Perez, Hana Hallak, Alex Godo, Carolina Sandoval-Garcia, Edgar G. Ordoñez-Rubiano, Angela Donaldson, Kaisorn L. Chaichana, María Peris-Celda, Bernard R. Bendok, Susan L. Samson, Alfredo Quinones-Hinojosa, Joao Paulo Almeida
Publikováno v:
Brain Sciences, Vol 13, Iss 6, p 842 (2023)
In recent years, the endoscopic endonasal approach (EEA) for craniopharyngiomas has proven to be a safe option for extensive tumor resection, with minimal or no manipulation of the optic nerves and excellent visualization of the superior hypophyseal
Externí odkaz:
https://doaj.org/article/6530893e4a7e4b76bcbd3dae2e6cb9c6