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pro vyhledávání: '"L. Saerens"'
Akademický článek
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Autor:
Cedric Raemdonck, Rainer Krüger, Jean Paul Remon, Dima Ghanam, L. Saerens, Chris Vervaet, Jürgen Manz, Thomas De Beer, Kjell Francois, Susan Krüger
Publikováno v:
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
The aim of this research was to use Raman spectroscopy for the in-line monitoring of the solid state of materials during pharmaceutical hot-melt extrusion in the die head of a 12 mm (development scale) twin-screw extruder during formulation developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a688f62f461763ac76fe3452e45aa27
https://doi.org/10.1016/j.ejpb.2014.03.002
https://doi.org/10.1016/j.ejpb.2014.03.002
Autor:
J.P. Remon, Chris Vervaet, Peter Adriaensens, Anouk Vervaeck, L. Saerens, B. G. De Geest, T. De Beer, Robert Carleer
Publikováno v:
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
In this study, prilling was evaluated as a technique for the development of multiparticulate dosage forms using the fatty acids, stearic acid, and behenic acid as potential matrix formers to control the release of metoprolol tartrate (MPT), a highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f160cc0f5c394a4e20dee7487fc1f8e
https://doi.org/10.1016/j.ejpb.2013.02.003
https://doi.org/10.1016/j.ejpb.2013.02.003
Publikováno v:
JOURNAL OF PHARMACY AND PHARMACOLOGY
Objectives Hot-melt extrusion (HME) is applied as a continuous pharmaceutical manufacturing process for the production of a variety of dosage forms and formulations. To ensure the continuity of this process, the quality of the extrudates must be asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9973b594ce10557746ac9e018ca14d9e
https://doi.org/10.1111/jphp.12123
https://doi.org/10.1111/jphp.12123
Publikováno v:
International Journal of Pharmaceutics. 439:223-229
The aim of the present work was to evaluate drug release and quality of EVA/drug matrices at different PEO 7M concentrations (5 and 15%), manufactured using two different hot-melt extruders: a lab-scale mini extruder and a pilot-scale extruder. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7df785172f4264f4e18a362f2dd7473
https://doi.org/10.1016/j.ijpharm.2012.09.037
https://doi.org/10.1016/j.ijpharm.2012.09.037
Autor:
T. Quinten, Jean Paul Remon, Wim Bouquet, T. De Beer, L. Saerens, Gavin Andrews, Chris Vervaet, Peter Hornsby, David S. Jones
Publikováno v:
AAPS PHARMSCITECH
Sustained-release matrix tablets based on Eudragit RL and RS were manufactured by injection moulding. The influence of process temperature; matrix composition; drug load, plasticizer level; and salt form of metoprolol: tartrate (MPT), fumarate (MPF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f2c355fd7a146095573658e7526233
https://doi.org/10.1208/s12249-012-9848-6
https://doi.org/10.1208/s12249-012-9848-6
Publikováno v:
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
The aim of this study was to develop a multilayer (core/coat) dosage form via co-extrusion, the core providing sustained drug release and the coat immediate drug release. In this study polymers were selected which can be combined in a co-extruded dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c98614d6126925388c705b9817006b
https://doi.org/10.1016/j.ejpb.2012.03.018
https://doi.org/10.1016/j.ejpb.2012.03.018
Autor:
L. Saerens, Jean Paul Remon, Lien Dierickx, Peter Adriaensens, T. Quinten, Chris Vervaet, Thomas De Beer, Robert Carleer
Publikováno v:
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
The aim was to evaluate near-infrared spectroscopy for the in-line determination of the drug concentration, the polymer-drug solid-state behaviour and molecular interactions during hot-melt extrusion. Kollidon® SR was extruded with varying metoprolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee37c2c7be47e10779dd8c8ddd426f6e
https://doi.org/10.1016/j.ejpb.2012.01.001
https://doi.org/10.1016/j.ejpb.2012.01.001
Autor:
L. Van Eycken, J. P. Bogers, B. Van Damme, C. Gompel, Carine Cuvelier, L. Saerens, Birgit Weynand, L Thienpont, Philippe Delvenne, Alain Verhest, M. Drijkoningen, Claire Bourgain
Publikováno v:
Cytopathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727837dec60c6a583a34da50db969bfe
https://doi.org/10.1111/j.1365-2303.2004.00228.x
https://doi.org/10.1111/j.1365-2303.2004.00228.x
Publikováno v:
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
This study focused on the evaluation of prilling as a technique for the manufacturing of multiparticulate dosage forms. Prills, providing controlled and immediate drug release, were processed and finally combined in capsules yielding a fixed-dose com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67ec55b28661daecf28f5cac5de67bb
https://pubmed.ncbi.nlm.nih.gov/25010389
https://pubmed.ncbi.nlm.nih.gov/25010389