Zobrazeno 1 - 10
of 253
pro vyhledávání: '"L. ST-PIERRE"'
Autor:
Philip J. Freda, Attri Ghosh, Elizabeth Zhang, Tianhao Luo, Apurva S. Chitre, Oksana Polesskaya, Celine L. St. Pierre, Jianjun Gao, Connor D. Martin, Hao Chen, Angel G. Garcia-Martinez, Tengfei Wang, Wenyan Han, Keita Ishiwari, Paul Meyer, Alexander Lamparelli, Christopher P. King, Abraham A. Palmer, Ruowang Li, Jason H. Moore
Publikováno v:
BioData Mining, Vol 16, Iss 1, Pp 1-24 (2023)
Abstract Background Quantitative Trait Locus (QTL) analysis and Genome-Wide Association Studies (GWAS) have the power to identify variants that capture significant levels of phenotypic variance in complex traits. However, effort and time are required
Externí odkaz:
https://doaj.org/article/dcc3146814494167aea71969b53c347c
Autor:
Sarah N. Wright, Brittany S. Leger, Sara Brin Rosenthal, Sophie N. Liu, Tongqiu Jia, Apurva S. Chitre, Oksana Polesskaya, Katie Holl, Jianjun Gao, Riyan Cheng, Angel Garcia Martinez, Anthony George, Alexander F. Gileta, Wenyan Han, Alesa H. Netzley, Christopher P. King, Alexander Lamparelli, Connor Martin, Celine L. St. Pierre, Tengfei Wang, Hannah Bimschleger, Jerry Richards, Keita Ishiwari, Hao Chen, Shelly B. Flagel, Paul Meyer, Terry E. Robinson, Leah C. Solberg Woods, Jason F. Kreisberg, Trey Ideker, Abraham A. Palmer
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112873- (2023)
Summary: A vexing observation in genome-wide association studies (GWASs) is that parallel analyses in different species may not identify orthologous genes. Here, we demonstrate that cross-species translation of GWASs can be greatly improved by an ana
Externí odkaz:
https://doaj.org/article/40d23e0993024b1ea31e653650c9f892
Autor:
Samuel Fowler, Tengfei Wang, Daniel Munro, Aman Kumar, Apurva S. Chitre, T. J. Hollingsworth, Angel Garcia Martinez, Celine L. St. Pierre, Hannah Bimschleger, Jianjun Gao, Riyan Cheng, Pejman Mohammadi, Hao Chen, Abraham A. Palmer, Oksana Polesskaya, Monica M. Jablonski
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Elevated intraocular pressure (IOP) is influenced by environmental and genetic factors. Increased IOP is a major risk factor for most types of glaucoma, including primary open angle glaucoma (POAG). Investigating the genetic basis of IOP may lead to
Externí odkaz:
https://doaj.org/article/f112d5721f474737b04bad488f8e2f87
Autor:
Alexander F Gileta, Christopher J Fitzpatrick, Apurva S Chitre, Celine L St Pierre, Elizabeth V Joyce, Rachael J Maguire, Africa M McLeod, Natalia M Gonzales, April E Williams, Jonathan D Morrow, Terry E Robinson, Shelly B Flagel, Abraham A Palmer
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010234 (2022)
Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. Despite this, the genetic characteristics of SD rats have not been clearly described, and SD rats are rarely used for experiments aimed at exploring genotype-
Externí odkaz:
https://doaj.org/article/981971953836450d8c94637971471c7b
Autor:
Alexander F. Gileta, Jianjun Gao, Apurva S. Chitre, Hannah V. Bimschleger, Celine L. St. Pierre, Shyam Gopalakrishnan, Abraham A. Palmer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 7, Pp 2195-2205 (2020)
The heterogeneous stock (HS) is an outbred rat population derived from eight inbred rat strains. HS rats are ideally suited for genome wide association studies; however, only a few genotyping microarrays have ever been designed for rats and none of t
Externí odkaz:
https://doaj.org/article/3aa4bd3693ad45488193d7ee910dee76
Autor:
Xinzhu Zhou, Celine L. St. Pierre, Natalia M. Gonzales, Jennifer Zou, Riyan Cheng, Apurva S. Chitre, Greta Sokoloff, Abraham A. Palmer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 3, Pp 951-965 (2020)
There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational inter
Externí odkaz:
https://doaj.org/article/aa0006589c614dc5a557d8cb71f21850
Autor:
Milad Mortazavi, Yangsu Ren, Shubham Saini, Danny Antaki, Celine L. St. Pierre, April Williams, Abhishek Sohni, Miles F. Wilkinson, Melissa Gymrek, Jonathan Sebat, Abraham A. Palmer
Publikováno v:
Cell Genomics, Vol 2, Iss 3, Pp 100102- (2022)
Summary: Mouse substrains are an invaluable model for understanding disease. We compared C57BL/6J, which is the most commonly used inbred mouse strain, with eight C57BL/6 and five C57BL/10 closely related inbred substrains. Whole-genome sequencing an
Externí odkaz:
https://doaj.org/article/5054ab5d148241bd8a1a1f891627b975
Autor:
Juan F Macias-Velasco, Celine L St Pierre, Jessica P Wayhart, Li Yin, Larry Spears, Mario A Miranda, Caryn Carson, Katsuhiko Funai, James M Cheverud, Clay F Semenkovich, Heather A Lawson
Publikováno v:
eLife, Vol 11 (2022)
Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes re
Externí odkaz:
https://doaj.org/article/544b0a3b284647ab9a32696c108eb34a
Autor:
Mario A. Miranda, Celine L. St Pierre, Juan F. Macias-Velasco, Huyen Anh Nguyen, Heather Schmidt, Lucian T. Agnello, Jessica P. Wayhart, Heather A. Lawson
Publikováno v:
Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Iron is a critical component of metabolic homeostasis, but consumption of dietary iron has increased dramatically in the last 30 years, corresponding with the rise of metabolic disease. While the link between iron metabolism and m
Externí odkaz:
https://doaj.org/article/40fed4ce4ae24cfeb19bfe9e6fc0fc02
Autor:
Mario A. Miranda, Caryn Carson, Celine L. St. Pierre, Juan F. Macias‐Velasco, Jing W. Hughes, Marcus Kunzmann, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
Publikováno v:
Physiological Reports, Vol 8, Iss 20, Pp n/a-n/a (2020)
Abstract Maintenance of functional β‐cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β‐cell populations to thrive or fail in the context of obesity are unknown. High fat‐fed SM/J mice spontaneously tr
Externí odkaz:
https://doaj.org/article/ac1457641c834e28b3bd00915e615bb4