Zobrazeno 1 - 10
of 24
pro vyhledávání: '"L. S. Sorkin"'
Autor:
G, Wigerblad, J R, Huie, H Z, Yin, M, Leinders, R A, Pritchard, F J, Koehrn, W-H, Xiao, G J, Bennett, R L, Huganir, A R, Ferguson, J H, Weiss, C I, Svensson, L S, Sorkin
Publikováno v:
Experimental neurology. 293
Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca2+ permeable AMPA receptor (AMPAr) contribute to spinal sensitization and resultant pain be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::077a993c14d77c14bff7f75d9ed2360a
https://pubmed.ncbi.nlm.nih.gov/28412220
https://pubmed.ncbi.nlm.nih.gov/28412220
Publikováno v:
APS Journal. 3:240-248
Summary The reader may have noted that we have tried to restrict our discussion to mechanisms of cutaneous hyperalgesia. We have taken the liberty to include some discussion of hyperalgesia produced by inflammation of deeper tissues and articular spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff8bff5d52f7e809f0555736d0294ed
https://doi.org/10.1016/s1058-9139(05)80271-2
https://doi.org/10.1016/s1058-9139(05)80271-2
Autor:
C. Owens, Donald A. Simone, Robert H. LaMotte, W. D. Willis, Jin Mo Chung, L. S. Sorkin, U. Oh
Publikováno v:
Journal of Neurophysiology. 66:228-246
1. The contribution of activity in spinothalamic tract (STT) neurons to the pain and neurogenic hyperalgesia produced by an intradermal injection of 100 micrograms of capsaicin was investigated. Electrophysiological responses of identified STT neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df435095188c9b41488dd4b2e63bcbc
https://doi.org/10.1152/jn.1991.66.1.228
https://doi.org/10.1152/jn.1991.66.1.228
Publikováno v:
Journal of Neurophysiology. 63:1118-1127
1. Recordings were made in anesthetized monkeys from neurons in the medullary reticular formation (MRF) caudal to the obex. Responses of 19 MRF neurons to mechanical, thermal, and/or electrical stimulation were examined. MRF neurons exhibited converg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc9e603cb8ab40e0ac4bc31b471f950
https://doi.org/10.1152/jn.1990.63.5.1118
https://doi.org/10.1152/jn.1990.63.5.1118
Publikováno v:
Schmerz (Berlin, Germany). 20(3)
Secondary mechanical hyperalgesia has been demonstrated in postoperative patients indicating that central sensitization occurs after surgery. However, the underlying mechanisms are unknown. Here, we studied the role of spinal AMPA/kainate receptors f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8fc0bc787653bdc6d8ee94e66bdcab3
https://pubmed.ncbi.nlm.nih.gov/16763860
https://pubmed.ncbi.nlm.nih.gov/16763860
Autor:
A R, Evans, H, Junger, M D, Southall, G D, Nicol, L S, Sorkin, J T, Broome, T W, Bailey, M R, Vasko
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(3)
Isoprostanes are a novel class of eicosanoids primarily formed by peroxidation of arachidonic acid. Because of their potential as inflammatory and/or hyperalgesic agents whose formation is largely independent of cyclooxygenases, we examined whether 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::187863ebb8879a8eddb9c3339403d776
https://pubmed.ncbi.nlm.nih.gov/10869392
https://pubmed.ncbi.nlm.nih.gov/10869392
Publikováno v:
Scopus-Elsevier
The role of excitatory amino acids (EAAs) in the excitation of monkey spinothalamic tract (STT) neurons following activation of cutaneous primary afferent fibers by noxious and non-noxious stimuli was investigated. The responses of STT neurons to eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7963dd813f5a8285acba001f81272139
https://europepmc.org/articles/PMC6575659/
https://europepmc.org/articles/PMC6575659/
Autor:
L S, Sorkin
Publikováno v:
The Mount Sinai journal of medicine, New York. 58(3)
Pain pathways in the spinal cord transmit information about actual or impending tissue damage. There are parallel pathways to both the medial (motivational-affective) and lateral (sensory-discriminative) portions of the system. Endogenous systems mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acb61cfa6bb92dfb1c37dc720b602e33
https://pubmed.ncbi.nlm.nih.gov/1652066
https://pubmed.ncbi.nlm.nih.gov/1652066
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 257(1)
The primary objective of this work was to investigate how in vivo administration of depolarizing agents increases extracellular concentrations of 5-hydroxytryptamine (5-HT) and simultaneously decreases levels of its chief metabolite 5-hydroxyindole-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::322a278fa34a3766748acc1334323e16
https://pubmed.ncbi.nlm.nih.gov/1708424
https://pubmed.ncbi.nlm.nih.gov/1708424
Publikováno v:
Progress in brain research. 88
Monoamine systems have been shown to be an important part of an endogenous analgesic system of the central nervous system. Some aspects of the anatomical basis of monoamine modulation of nociceptive input were investigated in these studies. Two sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bb04601b849d6b761408462e52e0260
https://pubmed.ncbi.nlm.nih.gov/1813936
https://pubmed.ncbi.nlm.nih.gov/1813936