Activation of K+ channels by stimulation of metabotropic glutamate receptors

Autor: Shin-Ho Chung, L. S. Premkumar

Publikováno v: Neuroreport. 6(5)

Single channel potassium currents activated indirectly via stimulation of metabotropic receptors were recorded in cell-attached patches on hippocampal neurones in slices from neonatal rats. When metabotropic receptors in the area outside of the patch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56de5bc1d67136c1c49070a84e21c2a7
https://pubmed.ncbi.nlm.nih.gov/7605944

Influence of GABA on Potassium Channels in Hippocampal Neurons

Autor: L. S. Premkumar, Shin-Ho Chung, Peter W. Gage

Publikováno v: Methods in Pharmacology ISBN: 9781441932327

A wide range of neurotransmitters, such as gamma-aminobutyric acid (GABA), serotonin (5-hydroxytryptamine, 5HT), acetylcholine, noradrenaline, dopamine, and adenosine, have been found to activate potassium channels in central neurons. It is possible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc7d55042ab2355590382409c2cd313e
https://doi.org/10.1007/978-1-4757-2239-0_7

Characterization of single channel currents using digital signal processing techniques based on Hidden Markov Models

Autor: L. S. Premkumar, John B. Moore, Peter W. Gage, Lige Xia, Shin-Ho Chung

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 329(1254)

Techniques for extracting small, single channel ion currents from background noise are described and tested. It is assumed that single channel currents are generated by a first-order, finite-state, discrete-time, Markov process to which is added 'whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666f76b2ef917db824a1f5dacc4da6d3
https://pubmed.ncbi.nlm.nih.gov/1702543

Muscarinic acetylcholine receptor produced in recombinant baculovirus infected Sf9 insect cells couples with endogenous G-proteins to activate ion channels

Autor: Peter W. Gage, Subhash G. Vasudevan, Helmut Reiländer, Shin-Ho Chung, L. S. Premkumar, Sally Stowe

Publikováno v: FEBS Letters. (1):7-11

Following the infection of insect ovarian cells (Sf9) with recombinant baculovirus bearing the cDNA coding for the rat muscarinic acetylcholine (ACh) receptor subtype m3, ionic flux across the membrane in response to the application of ACh was examin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012ec51de0823b1c01351fe29106ca7b

Advancing the field of viroporins-Structure, function and pharmacology: IUPHAR Review 39.

Autor: Devantier K; Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Kjær VMS; Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Griffin S; Leeds Institute of Medical Research, St James' University Hospital, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Kragelund BB; Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Rosenkilde MM; Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Nov; Vol. 181 (22), pp. 4450-4490. Date of Electronic Publication: 2024 Sep 03.