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Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization following affinity labeling

Autor: Francis M. Sirotnak, L S Mines, Ciyu Yang

Publikováno v: Journal of Biological Chemistry. 263:9703-9709

Studies are reported on the characterization of a new isolate within a novel class of variants of the L1210 cell exhibiting markedly increased transport inward of folate analogues. This variant (L1210/R83), which was selected in the presence of the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7867a16546f378e8da94b1d8610c1c5d
https://doi.org/10.1016/s0021-9258(19)81575-2

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Markedly altered membrane transport and intracellular binding of vincristine in multidrug-resistant Chinese hamster cells selected for resistance to vinca alkaloids

Autor: E. Oribé, F. M. Sirotnak, L. S. Mines, J. L. Biedler, Chen Yang

Publikováno v: Journal of Cellular Physiology. 126:266-274

Studies of a multidrug-resistant variant (DC-3F/VCRd-5L) of Chinese hamster lung cells selected for resistance to vinca alkaloids revealed marked alterations in transport and intracellular binding of [3H]vincristine compared to parental DC-3F cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d0c0f5e6ba6c8e1e655282a1562d4dc
https://doi.org/10.1002/jcp.1041260217

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Autor: C H, Yang, F M, Sirotnak, L S, Mines

Publikováno v: The Journal of biological chemistry. 263(20)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37c2f45b8a8acd7f221942818dc1f052
https://pubmed.ncbi.nlm.nih.gov/2838477

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Markedly altered membrane transport and intracellular binding of vincristine in multidrug-resistant Chinese hamster cells selected for resistance to vinca alkaloids

Autor: F M, Sirotnak, C H, Yang, L S, Mines, E, Oribé, J L, Biedler

Publikováno v: Journal of cellular physiology. 126(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33effc9b5cd314f9ad4ea4380afcc1ef
https://pubmed.ncbi.nlm.nih.gov/3944208

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Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions

Autor: F M, Sirotnak, L J, Goutas, D M, Jacobsen, L S, Mines, J R, Barrueco, Y, Gaumont, R L, Kisliuk

Publikováno v: Biochemical pharmacology. 36(10)

Comparison of the kinetic parameters for influx of highly purified [3H]folic acid versus [3H]methotrexate in L1210 cells under anionic buffer conditions showed a marked discordancy. In addition, the kinetics for influx of [3H]folic acid were unchange

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03b66d3185f5c427fd817a37b51ba9a1
https://pubmed.ncbi.nlm.nih.gov/3593392

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