Zobrazeno 1 - 10
of 173
pro vyhledávání: '"L. S. Chan"'
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Adoption of immunotherapy has completely transformed the treatment landscape of cancer. Patients with advanced cancer treated with immunotherapy may benefit from durable tumor response and long-term survival. The most widely used immunotherapy in sol
Externí odkaz:
https://doaj.org/article/9bc612db785f42f3ab18cd6540131412
Autor:
Phylinda L. S. Chan, Ravi Shankar P. Singh, Donna S. Cox, Haihong Shi, Bharat Damle, Timothy Nicholas
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1897-1910 (2023)
Abstract Protease inhibitor nirmatrelvir coadministered with ritonavir as a pharmacokinetic enhancer (PAXLOVID™; Pfizer Inc) became the first orally bioavailable antiviral agent granted Emergency Use Authorization in the United States in patients
Externí odkaz:
https://doaj.org/article/b476a8db40e94b18a86663a6931272c5
Autor:
Johnson C. Y. Pang, Eric L. S. Chan, Herman M. C. Lau, Kara K. L. Reeves, Tina H. Y. Chung, Heidi W. L. Hui, Alfred H. L. Leung, Allan C. L. Fu
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundThe COVID-19 pandemic has greatly affected the level of physical activity (PA). However, little is known about its effect on health outcomes.MethodsArticles without language restrictions published from the database inception through March 1
Externí odkaz:
https://doaj.org/article/85095e89489640a8961df440d2c04e15
Autor:
Yanhao Lai, Helen Budworth, Jill M. Beaver, Nelson L. S. Chan, Zunzhen Zhang, Cynthia T. McMurray, Yuan Liu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during l
Externí odkaz:
https://doaj.org/article/3879ba8a8aee40aca671630c5cc0af1e
Autor:
Akosua A. Agyeman, Tao You, Phylinda L. S. Chan, Dagan O. Lonsdale, Christoforos Hadjichrysanthou, Tabitha Mahungu, Emmanuel Q. Wey, David M. Lowe, Marc C. I. Lipman, Judy Breuer, Frank Kloprogge, Joseph F. Standing
Pharmacometric analyses of time series viral load data may detect drug effects with greater power than approaches using single time points. Because SARS-CoV-2 viral load rapidly rises and then falls, viral dynamic models have been used. We compared d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2b1c0db3117b20284437b7183e2aa8
Autor:
Lynn McFadyen, Jennifer Hammond, Susan Raber, Victoria M Hendrick, Heidi Leister-Tebbe, Andrea Quaye, Phylinda L. S. Chan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 6, Pp 551-563 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
A model‐informed drug development approach was used to select ceftaroline fosamil high‐dose regimens for pediatric patients with complicated skin and soft‐tissue infections caused by Staphylococcus aureus with a ceftaroline minimum inhibitory c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf3ebed81cf9fec93c1b632a8576762
https://doi.org/10.1002/psp4.12608
https://doi.org/10.1002/psp4.12608
Autor:
W Reinisch, G De Hertogh, M Protic, L S Chan, F Magro, P Pollack, B G Feagan, N Harpaz, R Pai
Publikováno v:
Journal of Crohn's and Colitis. 16:i103-i105
Background The role of histopathology evaluation in Crohn’s disease (CD) is not precisely defined. Due to the heterogeneity of phenotypes, the discontinuity of distribution, and the transmural nature of inflammation, the interpretation of histologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::851606bb96a8a46ef5514f867af50bb1
https://doi.org/10.1093/ecco-jcc/jjab232.095
https://doi.org/10.1093/ecco-jcc/jjab232.095
Publikováno v:
Clinical Pharmacology in Drug Development
The key pharmacokinetic/pharmacodynamic (PK/PD) efficacy index for β‐lactam antibiotics is the percentage of time that free drug concentrations exceed the minimum inhibitory concentration (MIC) of bacteria during each dosing interval (fT>MIC). Cef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890be20a6dfab07830883cf6c5d19591
https://doi.org/10.1002/cpdd.907
https://doi.org/10.1002/cpdd.907
Publikováno v:
Clinical Pharmacology and Therapeutics
Pregabalin is approved in multiple countries as adjunctive therapy for adult patients with focal onset seizures (FOS; previously termed partial onset seizures). This study used population pharmacokinetic (PK) and exposure-response (E-R) analyses from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0ab313549fe72840d5c4adc97f9b0a
http://europepmc.org/articles/PMC8359225
http://europepmc.org/articles/PMC8359225
Autor:
Manoli Vourvahis, Timothy J. Carrothers, Lynn McFadyen, John S. Bradley, Mark Lovern, Todd Riccobene, Susan Raber, Richard C. Franzese, Kenny J. Watson, Phylinda L. S. Chan
Publikováno v:
Clinical pharmacology and therapeutics, vol 111, iss 3
Increasing prevalence of infections caused by antimicrobial-resistant gram-negative bacteria represents a global health crisis, and while several novel therapies that target various aspects of antimicrobial resistance have been introduced in recent y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596328c6515dcf6576a4e0e2e86d82c2
https://escholarship.org/uc/item/456322xv
https://escholarship.org/uc/item/456322xv