Zobrazeno 1 - 8
of 8
pro vyhledávání: '"L. Richard Bridges"'
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 4, Pp 925-933 (2013)
SUMMARY Tuberous sclerosis complex (TSC) is a multi-organ disorder caused by mutations of the TSC1 or TSC2 genes. A key function of these genes is to inhibit mTORC1 (mechanistic target of rapamycin complex 1) kinase signaling. Cells deficient for TSC
Externí odkaz:
https://doaj.org/article/7a2a21fc0fd343da8b32afd0750c450f
Autor:
Christopher J. Long, L. Richard Bridges, Keisha Persaud, Christopher W. McAleer, James J. Hickman, Carlota Oleaga
Publikováno v:
Biotechnology Progress. 37
Human in vitro hepatic models generate faster drug toxicity data with higher human predictability compared to animal models. However, for long-term studies, current models require the use of serum and 3D architecture, limiting their utility. Maintain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b58448af5430c7a8b6d19dfe35242e
https://doi.org/10.1002/btpr.3069
https://doi.org/10.1002/btpr.3069
Autor:
Carlota Oleaga, Anne Riu, Sandra Rothemund, Andrea Lavado, Christopher W. McAleer, Christopher J. Long, Keisha Persaud, Narasimhan Sriram Narasimhan, My Tran, Jeffry Roles, Carlos A. Carmona-Moran, Trevor Sasserath, Daniel H. Elbrecht, Lee Kumanchik, L. Richard Bridges, Candace Martin, Mark T. Schnepper, Gail Ekman, Max Jackson, Ying I. Wang, Reine Note, Jessica Langer, Silvia Teissier, James J. Hickman
Publikováno v:
Biomaterials. 182:176-190
Regulation of cosmetic testing and poor predictivity of preclinical drug studies has spurred efforts to develop new methods for systemic toxicity. Current in vitro assays do not fully represent physiology, often lacking xenobiotic metabolism. Functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33285a19753400fcca5f893bc71584ac
https://doi.org/10.1016/j.biomaterials.2018.07.062
https://doi.org/10.1016/j.biomaterials.2018.07.062
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics
Autor:
Mark T. Schnepper, L. Richard Bridges, Christopher W. McAleer, Christopher J. Long, Michael L. Shuler, Candace Martin, James J. Hickman, Daniel Elbrecht, Adrian Roth, Franz Schuler, Trevor Sasserath, John W. Rumsey, Ying Wang, Christoph Funk
Publikováno v:
Science Translational Medicine. 11
A pumpless, reconfigurable, multi-organ-on-a-chip system containing recirculating serum-free medium can be used to predict preclinical on-target efficacy, metabolic conversion, and measurement of off-target toxicity of drugs using functional biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7725f69df9a5036fd561e0fc98793e
https://doi.org/10.1126/scitranslmed.aav1386
https://doi.org/10.1126/scitranslmed.aav1386
Autor:
Victorine P. Muse, Benjamin D. Wilkin, Dominic P. Williams, Abhishek Srivastava, Kristin M. Fabre, Jeff Roles, Christopher J. Long, Amy Pointon, Narasimham Narasimhan Sriram, Rocky L. Brighton, Michael L. Shuler, Lorna Ewart, Mark T. Schnepper, Christopher W. McAleer, James J. Hickman, Jerome T. Mettetal, L. Richard Bridges, Robin McDougall
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Functional human-on-a-chip systems hold great promise to enable quantitative translation to in vivo outcomes. Here, we explored this concept using a pumpless heart only and heart:liver system to evaluate the temporal pharmacokinetic/pharmacodynamic (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe535bd131368e6c0bdf944927b44f28
https://pubmed.ncbi.nlm.nih.gov/31270362
https://pubmed.ncbi.nlm.nih.gov/31270362
Autor:
Carlota Oleaga, Candace Martin, Yunqing Cai, James J. Hickman, Lee Kumanchik, Gregg Legters, L. Richard Bridges, Mark T. Schnepper, Christopher W. McAleer, Christopher J. Long
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493966592
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a38d4aa167b51a011dc7111fb562e163
https://doi.org/10.1007/978-1-4939-6661-5_12
https://doi.org/10.1007/978-1-4939-6661-5_12
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 6, Iss 4, Pp 925-933 (2013)
Disease Models & Mechanisms, Vol 6, Iss 4, Pp 925-933 (2013)
Summary Tuberous sclerosis complex (TSC) is a multi-organ disorder caused by mutations of the TSC1 or TSC2 genes. A key function of these genes is to inhibit mTORC1 (mechanistic target of rapamycin complex 1) kinase signaling. Cells deficient for TSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91c7e48f47517767649fb80e7b7d28a
https://doi.org/10.1242/jcs.137752
https://doi.org/10.1242/jcs.137752