Zobrazeno 1 - 2
of 2
pro vyhledávání: '"L. Rebecca Fish"'
Autor:
Hugo M. Vargas, Smita Patel, Kevin John Merchant, Angus Murray Macleod, T. Ladduwahetty, L. Rebecca Fish, Elisabeth Philipps, Magnus Ivarsson, Peter H. Hutson, Myra Gilligan, Desmond O'Connor, Alexander Charles Humphries
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3665-3669
Incorporation of fluorine at the 4-position of an existing series of sulfonyl piperidine 5-HT2A antagonists gave compounds with increased selectivity over the IKr potassium channel. This work led to the identification of 3b, a compound that gave no i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce252d18f24a4f0dde61edfaa1efbb3b
https://doi.org/10.1016/j.bmcl.2005.05.104
https://doi.org/10.1016/j.bmcl.2005.05.104
Autor:
Angus Murray Macleod, L. Rebecca Fish, Monique Bodil Van Niel, Desmond O'Connor, Laura Catherine Cooper, Kevin J. Wilson, Dawn Bloomfield
Publikováno v:
ChemInform. 38
This report describes the effect of replacing the central basic amine present in many known 5-HT2A ligands with an aromatic residue. We targeted the isomeric phenethylpyridines 2 and 3 and these compounds proved to be excellent leads, possessing good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a8924f4f07d6e2607a9ecc47a84fc2
https://doi.org/10.1002/chin.200736216
https://doi.org/10.1002/chin.200736216