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Elektronická kniha

Autor: M. Ghione, L. Rausa, A. Pellegrini

First Published in 1988. This is a collection of the Proceedings of a course held at the International School of Medical Sciences Ettore Majorana Centre for Scientific Culture, Italy 5-13 September 1986.

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5-Fluorouracil plus interferon α-2a compared to 5-fluorouracil alone in the treatment of advanced colon carcinoma: A multicentric randomized study

Autor: S. Palmeri, M. Meli, M. Danova, G. Bernardo, V. Leonardi, G. Dastoli, L. Rausa, A. Russo, G. Filippelli, G. Palmieri, M. Della Vittoria Scarpati, V. Lo Russo, L. Di Lauro, G. Colucci, G. Bruni, M. Piazzi, N. Gebbia, S. Spada

Publikováno v: Journal of Cancer Research and Clinical Oncology. 124:191-198

Biochemical modulation is one of the most interesting fields in cancer chemotherapy. Interferon-alpha (IFNalpha) is a cytokine that is able to influence the pharmacodynamics of 5-fluorouracil (5FU) through a number of mechanisms. With the aim of conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73de88dcd363b22f0f24aeb8cced5f0a
https://doi.org/10.1007/s004320050154

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A short-term infusion regimen of Cisplatin, 5-Fluorouracil and L-folinic Acid in advanced head and neck-carcinoma

Autor: V. Leonardi, Maria Meli, Sergio Palmeri, L. Rausa, G. Failla, Marco Danova, P. Ferrara, Marco Benazzo, Silvia Brugnatelli, Antonio Russo

Publikováno v: Oncology reports. 1(6)

Treatment of advanced head and neck cancer is still a matter of controversy. Although current chemotherapy regimens are able to induce high response rates, they have not shown improved survival. We employed a combination of cisplatin (CDDP), 5-fluoro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c6bea99eb6eb80b63fb81d40fcc192
https://pubmed.ncbi.nlm.nih.gov/21607506

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Is an antiemetic prophylactic treatment needed for patients submitted to consecutive days of 5-fluorouracil? An observational study

Autor: C. Presot, M. S. Dionisi, A. Lucenti, M. Minelli, M. Antimi, P. Manente, Massimo Federico, E. Sansoni, C. M. Foggi, T. Buniva, D. Negri, Giovanni Quarta, Albano Del Favero, Maurizio Tonato, D. Amadori, C. Epifani, M. Maltoni, G. Gorzegno, M. Giordano, C. Milandri, R. Casaretti, G. Ciccarese, P. Marchei, F. De Vita, I. Carreca, V. Fosser, D. Donati, G. Cruciani, S. Della Gaspera, F. M. Gioffré, L. De Sio, B. Agostara, Verena De Angelis, Roberto Sabbatini, Fausto Roila, R. Sabbioni, R. Maccaferri, G. Villani, G. Bernardo, M. R. Strada, A. Contu, G. Amunni, A. Villanucci, S. Schiavon, S. Tumolo, A. Pazzola, C. Caroti, L. Merlini, A. Amodio, M. Marzi, G. Garofolo, G. Catalano, L. Dogliotti, P. Alessadroni, P. Malacarne, M. Ceccolini, F. Conti, F. Di Costanzo, L. Rausa, M. A. Palladino, M. Lopez, L. Montanari, L. Gallo, G. Iodice, G. L. Cetto, A. Venuti, S. Mazzotta, M. T. Cattaneo, C. Pacilio, G. Palmiotti, R. Nortilli, R. Forcignanò, G. Troccoli, A. Giglio, G. Comella, G. Rosati, Enzo Ballatori, S. Amici, Roberta Depenni, Vittorio Silingardi, S. Porrozzi, L. Meneghetti, G. Muran, B. Orlandini

Publikováno v: Scopus-Elsevier

Aims and Background The necessity of an antiemetic prophylaxis in patients treated with chemotherapy of low emetogenic potential, such as 5-fluorouracil ± folinic acid fractionated over several consecutive days, is controversial. The aim of the stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0023512f3fb0b9df8ba47542b191434
https://pubmed.ncbi.nlm.nih.gov/11989589

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Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer. A preliminary study

Autor: R, Sanguedolce, R, Alessandro, G, De Leo, L, Gullotti, F, Sanguedolce, G, Vultaggio, G, Diana, B, Cirello, L, Rausa

Publikováno v: Anticancer research. 20(6B)

Structural changes in the macromolecular targets of pharmacological agents can result in alterations in the efficacy of these agents. In previous studies Berger et al. (1) identified a variant structural form of thymidylate synthase (TS) that is asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af3a84d7adf506a7628b431a4ebec7e7
https://pubmed.ncbi.nlm.nih.gov/11205269

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In vitro generation of cytotoxic T lymphocytes against HLA-A2.1-restricted peptides derived from human thymidylate synthase

Autor: Maria Grazia Cusi, Sp Prete, Pierpaolo Correale, L Rausa, Roberto Petrioli, M Sabatino, Giorgio Giorgi, Guido Francini, A. Aquino, Mario Turriziani, Cristina Nencini, R Sanguedolce, L De Vecchis, Daniele Pozzessere, Lucia Micheli

Publikováno v: Europe PubMed Central
Università degli Studi di Siena-IRIS
Scopus-Elsevier

5-Fluorouracil (5-FU) is a pyrimidine antimetabolite active against colorectal carcinoma and other malignancies of the digestive tract. Over-expression or mutation of thymidylate synthase (TS), the target enzyme of the 5-FU metabolite, 5-fluorodeoxyu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b513e3d09d9308b191a89c52952e5f
http://hdl.handle.net/11365/35667

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The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer

Autor: R, Sanguedolce, G, Vultaggio, F, Sanguedolce, G, Modica, F, Li Volsi, G, Diana, G, Guereio, L, Bellanca, L, Rausa

Publikováno v: Anticancer research. 18(3A)

Inhibition of Thymidylate Synthase (TS) by the 5-Fluorouracil (5Fu) active metabolite Fluoro-deoxy-uridine-monophosphate (FdUMP) is considered to be the main mechanism of action of 5Fu. TS level from tumors and normal mucosa of 62 untreated patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff9f2895bcd2428f54216205f1024b32
https://pubmed.ncbi.nlm.nih.gov/9673363

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A cisplatin-based regimen as a salvage treatment for metastatic breast carcinoma

Autor: Leonardi, Maria Meli, L. Rausa, Antonio Russo, Sergio Palmeri

Publikováno v: Oncology Reports.

The role of chemotherapy in refractory metastatic breast cancer is still debated. We employed a schedule of cisplatin, mitomycin and vindesine in twenty-one anthracycline- or anthraquinone-pretreated breast cancer patients. The most relevant characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51db4a9c5365d79c302f6f779b19d9d2
https://doi.org/10.3892/or.3.6.1079

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