Zobrazeno 1 - 10 of 42 pro vyhledávání: '"L. Radesca"'
1
Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists
Autor: Kenner C. Rice, Christina M. Dersch, Karen M. Becketts, L. Radesca, Brian R. de Costa, Richard B. Rothman, F. Ivy Carroll
Publikováno v: Life Sciences. 53:PL267-PL272
The cocaine receptor on the dopamine transporter is a logical target binding site for the design and synthesis of novel agents for evaluation as possible cocaine antagonists. Although there is no widely accepted and validated assay for detecting a co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87419882a1e8591b63df5357362c5f70
https://doi.org/10.1016/0024-3205(93)90602-y
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5
Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity .sigma. receptor ligands. Identification of a new class of highly potent and selective .sigma. receptor probes
Autor: B R, de Costa, K C, Rice, W D, Bowen, A, Thurkauf, R B, Rothman, L, Band, A E, Jacobson, L, Radesca, P C, Contreras, N M, Gray
Publikováno v: Journal of Medicinal Chemistry. 33:3100-3110
Certain benzeneacetamides [(-)- and (+)-cis-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]benzeneacetamide] were recently reported to be potent sigma receptor ligands. In order to determine whether efficacy for the sigma receptor could be im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad164d2f1ddd86bd8b07ac3777c97e9d
https://doi.org/10.1021/jm00173a030
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6
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909)
Autor: Kenner C. Rice, F.H.E. Wojnicki, Glowa, L. Radesca, Christina M. Dersch, Agu Pert, Richard B. Rothman, Dorota Matecka, John S. Partilla, de Costa Br
Publikováno v: Journal of medicinal chemistry. 39(24)
The design, synthesis, and biological evaluation of compounds related to the dopamine (DA) uptake inhibitors: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (1) and 1-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (2)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e16bbc23d0adeaf95157bc3189e6bdc
https://pubmed.ncbi.nlm.nih.gov/8941383
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7
Identification of a GBR12935 homolog, LR1111, which is over 4,000-fold selective for the dopamine transporter, relative to serotonin and norepinephrine transporters
Autor: Bruce Lewis, Kenner C. Rice, Chris Dersch, L. Radesca, Brian R. de Costa, Richard B. Rothman, Hyacinth C. Akunne, Heng Xu, Agu Pert, Robert B. Kilburn
Publikováno v: Synapse (New York, N.Y.). 14(1)
The di-substituted piperazines, GBR12909 (1-[2-[bis(4-fluorophenyl)-methoxy]ethyl]-4-[3-phenylpropyl]piperazine) and GBR12935 (1-[2-(diphenyl-methoxy)-ethyl]-4-(3-phenylpropyl)piperazine), are potent and selective (20-to 100-fold) inhibitors of [3H]d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbfd45b03f3ff3cd4f36bf2ad157511
https://pubmed.ncbi.nlm.nih.gov/8511716
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8
Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes
Autor: Xiao-shu He, W. D. Bowen, L. Radesca, B. R. De Costa, Wanda Williams, Celia Dominguez
Publikováno v: Journal of medicinal chemistry. 35(23)
The synthesis and sigma receptor affinity of a series of conformationally restricted derivatives of 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenedi amine (1) is described. The pyrrolidinyl (or N,N-dialkyl),ethylenediamine,N-alky
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ac155bb4b1639510f996c78eb32877
https://pubmed.ncbi.nlm.nih.gov/1447735
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9
Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents
Autor: W. D. Bowen, Celia Dominguez, B. R. De Costa, L. Radesca, L Di Paolo
Publikováno v: Journal of medicinal chemistry. 35(12)
Unlabeled fluoro- and iodo-substituted ligands exhibiting very high affinity and selectivity for sigma receptors were synthesized based on three different structural classes of sigma receptor ligands. These compounds were evaluated for sigma receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fad616590e68e183ea526ca30e4198a
https://pubmed.ncbi.nlm.nih.gov/1319493
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