Challenge of cardiovascular prevention in primary care: achievement of lifestyle, blood pressure, lipids and diabetes targets for primary prevention in England – results from ASPIRE-3-PREVENT cross-sectional survey

Autor: A Brown, Richard Hobbs, S Jones, J Davies, S Taylor, D Wood, J Cook, T Mason, J Clarke, C Brown, N Ghuman, R Fox, C Jones, S Uddin, J Wilson, C Bell, H Wilson, David Wood, Kornelia Kotseva, Agnieszka Adamska, A Adamska, S Adamska, C Jennings, K Kotseva, P Atkin, C Thomas, A Oliver, C Cox, A Dunne, D Kelly, M Stone, K Beck, J Taylor, S Hunt, J Ryan, P Griffiths, D Shukla, S Richardson, P Steadman, V Glover, N Coote, D Corbett, C Gibbon, F Doyle, L Owen, C Thornley, S Dean, S McKee, N Chauhan, J Howell, R Coles, R Hobbs, K Duff, M Arthur, Catriona Jennings, D Lonsdale, L Steel, T Holt, L Rosenberg, S Cartwright, J Rooney, N Qamar, S Shillito, M Zerominska, U Khan O Hussein, A Ballintine, A Isaew, S Spannuth, J Timmins, F Spannuth, A Agasou, L Andrew, R Hibbell, S Hollishead, S Mazilu-Wood, M Oakley, J Simm, T Nyguyen, C Talbot, R Crowe, K Hollier, T Hembrough, R Symonds, D Diprose, J Beecham, S Bosel-Doyle, L S Taylor, K Priddis, C Winch, S Wytrykowski, Dr L Jones, E Ogburn, N Wooding, S Maslen, C Naylo, R Horsley, H Nobeebaccus, E Tomlinson, L Chaytor, S Garnham, Z Martin, S Mononga, S Steed, S Galbraith-Gibbons, T Sevenoaks

Publikováno v: Open Heart, Vol 11, Iss 2 (2024)

Background Implementation of the cardiovascular disease (CVD) prevention guidelines in the UK has been repeatedly evaluated under the auspices of the British Cardiovascular Society in three Action on Secondary and Primary Prevention by Intervention t

Externí odkaz: https://doaj.org/article/6b748f79da934306af127a3405272dde

Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease

Autor: Ana-Caroline Raulin, Sydney V. Doss, Michael G. Heckman, Emily C. Craver, Zonghua Li, Tadafumi C. Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A. Martens, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Michael DeTure, R. Ross Reichard, Aivi T. Nguyen, Eleni Constantopoulos, Rachel A. Larsen, Emmaline K. Kounaves, Melissa E. Murray, Dennis W. Dickson, Ronald C. Petersen, Guojun Bu, Takahisa Kanekiyo

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)

Abstract Alzheimer’s disease (AD), characterized by the deposition of amyloid-β (Aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau (pTau), is increasingly recognized as a complex disease with multiple pathologies. AD sometim

Externí odkaz: https://doaj.org/article/8f5535e35e724bf6989bb41e302e114e

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

Autor: Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu

Publikováno v: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)

Abstract Background The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expre

Externí odkaz: https://doaj.org/article/aeb26e05f9954b82bf1169b444687ab2

Quantum Science and Technologies in K-12: Supporting Teachers to Integrate Quantum in STEM Classrooms

Autor: Nancy Holincheck, Jessica L. Rosenberg, Xiaolu Zhang, Tiffany N. Butler, Michele Colandene, Benjamin W. Dreyfus

Publikováno v: Education Sciences, Vol 14, Iss 3, p 219 (2024)

Quantum science and computing represent a vital intersection between science and technology, gaining increasing importance in modern society. There is a pressing need to incorporate these concepts into the K-12 curriculum, equipping new generations w

Externí odkaz: https://doaj.org/article/4271f5db653e442aa88ada9266536d79

Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

Autor: Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu

Publikováno v: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)

Externí odkaz: https://doaj.org/article/4511001c5918420e8c1acb46c93860e6