Zobrazeno 1 - 10
of 45
pro vyhledávání: '"L. R. Pohl"'
Publikováno v:
Journal of Biological Chemistry. 266:18415-18418
Antibodies raised against halothane metabolite adducts cross-react with S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC) and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine metabolite adducts. Using these antibodies in immunohistochemical experiments, met
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(2)
Sulfonamide antimicrobials cause a delayed-onset, hypersensitivity-type syndrome characterized by fever, skin rash and multiorgan toxicity occurring 7 to 14 days after initiation of therapy. The pathogenesis is believed to be immune-mediated. We inve
Autor:
H R, Amouzadeh, L R, Pohl
Publikováno v:
Hepatology (Baltimore, Md.). 22(3)
In this study we have investigated the mechanism of the processing of trifluoroacetylated liver microsomal protein antigens associated with halothane hepatitis to learn how the immune system might come in contact with these proteins to form antibodie
Publikováno v:
Arthritis and rheumatism. 37(7)
Autor:
J L, Martin, D A, Dubbink, D J, Plevak, A, Peronne, H F, Taswell, E J, Hay, N R, Pumford, L R, Pohl
Publikováno v:
Anesthesia and analgesia. 74(4)
Publikováno v:
The Journal of biological chemistry. 266(28)
Antibodies raised against halothane metabolite adducts cross-react with S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC) and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine metabolite adducts. Using these antibodies in immunohistochemical experiments, met
Publikováno v:
The Journal of biological chemistry. 266(5)
The reductive debromination of BrCCl3 by ferrous deoxymyoglobin leads to the covalent bonding of the prosthetic heme to the protein. We have previously shown, by the use of peptide mapping and mass spectrometry, that histidine residue 93 is covalentl
Autor:
L R, Pohl, D, Thomassen, N R, Pumford, L E, Butler, H, Satoh, V J, Ferrans, A, Perrone, B M, Martin, J L, Martin
Publikováno v:
Advances in experimental medicine and biology. 283
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(5)
Previous studies have shown that antibodies in the sera of halothane hepatitis patients recognize trifluoroacetylated liver microsomal proteins (neoantigens) of 100 kDa, 76 kDa, 59 kDa, 57 kDa, and 54 kDa. In the present investigation, factors that m
Autor:
Y, Osawa, B M, Martin, P R, Griffin, J R, Yates, J, Shabanowitz, D F, Hunt, A C, Murphy, L, Chen, R J, Cotter, L R, Pohl
Publikováno v:
The Journal of biological chemistry. 265(18)
The reductive metabolism of BrCCl3 by ferrous myoglobin leads to the alteration of the prosthetic heme to form products that can be dissociated from the protein and to those that are irreversibly bound to the protein. The major dissociable or soluble