Zobrazeno 1 - 8 of 8 pro vyhledávání: '"L. R. Kauffman"'
2
Nonlinear pharmacokinetics of efavirenz (DMP-266), a potent HIV-1 reverse transcriptase inhibitor, in rats and monkeys
Autor: S K, Balani, L R, Kauffman, F A, deLuna, J H, Lin
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 27(1)
Efavirenz (EFV, Sustiva, Stocrin, DMP-266, L-743,726) is a potent and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Pharmacokinetics of EFV was studied in rats and monkeys, the safety assessment species. In rats, after 2 and 5 mg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f71f4d1fb9dcc98632e8cf21c2a5c9d7
https://pubmed.ncbi.nlm.nih.gov/9884307
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3
Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human
Autor: T, Prueksaritanont, S K, Balani, L M, Dwyer, J D, Ellis, L R, Kauffman, S L, Varga, S M, Pitzenberger, A D, Theoharides
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(7)
In vivo and in vitro metabolism of 6-chloro-4(S)-cyclopropyl-3,4-dihydro-4-((2-pyridyl) ethynyl)quinazolin-2(1H)-one (L-738,372), a potent human immunodeficiency virus-type 1 reverse transcriptase inhibitor, has been investigated in rats, dogs, and m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e07728a291f89cae647e696748cb299
https://pubmed.ncbi.nlm.nih.gov/7587955
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4
Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine
Autor: S K, Balani, B H, Arison, L, Mathai, L R, Kauffman, R R, Miller, R A, Stearns, I W, Chen, J H, Lin
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(2)
L-735,524, N-[2(R)-hydroxy-1(S)-indanyl]-5-(2(S)-(1,1- dimethylethylaminocarbonyl)-4-[(pyridin-3-yl)methyl]piperazin++ +-1-yl)-4(S)- hydroxy-2(R)-phenylmethylpentanamide, is a potent and specific inhibitor of the human immunodeficiency virus type 1 p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf124a805eeee11e5a92200762176679
https://pubmed.ncbi.nlm.nih.gov/7736923
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5
Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans
Autor: S K, Balani, L R, Kauffman, B H, Arison, T V, Olah, M E, Goldman, S L, Varga, J A, O'Brien, H G, Ramjit, C S, Rooney, J M, Hoffman
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 22(2)
Healthy subjects were administered single oral doses of 800 mg or 400 mg 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-o ne (L-696,229), a nonnucleoside inhibitor of the human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f3b05f830da12a350553ba86539a964
https://pubmed.ncbi.nlm.nih.gov/7516852
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6
Biotransformation of 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005) in rhesus monkeys and rat liver microsomes to a potent HIV-1 reverse transcriptase inhibitor
Autor: S K, Balani, M E, Goldman, L R, Kauffman, S L, Varga, J A, O'Brien, S J, Smith, T V, Olah, H G, Ramjit, T W, Schorn, S M, Pitzenberger
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(4)
Rhesus monkeys were dosed orally with 10 mg/kg 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005), a nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, in polyethylene glycol 300. Plasma samples from these m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c630e06f63cb2f44848b9d81ec13a2a
https://pubmed.ncbi.nlm.nih.gov/7690697
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7
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase
Autor: William J. Greenlee, S K Balani, L. R. Kauffman, Mark E. Goldman, Clarence S. Rooney, Jon H. Condra, Emilio A. Emini, S. C. Mactough, Terrence M. Ciccarone, Theresa M. Williams
Publikováno v: Journal of medicinal chemistry. 36(9)
A series of highly potent, structurally novel, non-nucleoside RT inhibitors has been described. Low nanomolar concentrations of 5-chloro-3-(phenylsulfonyl)-indole-2-carboxamide (1) inhibit the HIV-1 RT enzyme in vitro and HTLVIIIb viral spread in MT-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc6ccdc5cee375b7a1784cc0e52b4e3
https://pubmed.ncbi.nlm.nih.gov/7683725
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8
Metabolism of a new HIV-1 reverse transcriptase inhibitor, 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (L-696,229), in rat and liver slices
Autor: S K, Balani, S M, Pitzenberger, L R, Kauffman, B H, Arison, H G, Ramjit, M E, Goldman, J A, O'Brien, J D, King, J M, Hoffman, C S, Rooney
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(6)
L-696,229 is a potent and specific inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and is currently undergoing clinical evaluation. In vivo metabolism in rats was investigated using an intravenous bolus dose of 5 mg/kg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed22e357665c8d065cdb1964709980dd
https://pubmed.ncbi.nlm.nih.gov/1283569
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