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Akademický článek

Impact of California Statute on Naloxone Availability and Opioid Overdose Rates

Autor: Tara L. Gallant, BA, Andrew R. Gilbert, BS, Sina Zargham, BA, Michael F. Di Lorenzo, MS, Jose L. Puglisi, PhD, Zachary R. Nicholas, MD, Valerie A. Gerriets, PhD

Publikováno v: AJPM Focus, Vol 2, Iss 3, Pp 100112- (2023)

Introduction: Ensuring that people at risk of overdosing on opioids have easy access to naloxone is an essential part of the fight against the opioid crisis. This study evaluates the impact of the 2016 California law (CA AB1535) permitting pharmacies

Externí odkaz: https://doaj.org/article/d25ee56e983f4f018a20c6a48a743353

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Akademický článek

Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains

Autor: Lu Ren, Phung N. Thai, Raghavender Reddy Gopireddy, Valeriy Timofeyev, Hannah A. Ledford, Ryan L. Woltz, Seojin Park, Jose L. Puglisi, Claudia M. Moreno, Luis Fernando Santana, Alana C. Conti, Michael I. Kotlikoff, Yang Kevin Xiang, Vladimir Yarov-Yarovoy, Manuela Zaccolo, Xiao-Dong Zhang, Ebenezer N. Yamoah, Manuel F. Navedo, Nipavan Chiamvimonvat

Publikováno v: JCI Insight, Vol 7, Iss 22 (2022)

Sinoatrial node (SAN) cells are the heart’s primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of cAMP. There

Externí odkaz: https://doaj.org/article/a77e387d0aea4cd39fe56437febaaf3a

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Akademický článek

Community investment interventions as a means for decarceration: A scoping review

Autor: L Hawks, E Lopoo, L Puglisi, J Cellini, K Thompson, AA Halberstam, D Tolliver, S Martinez-Hamilton, EA Wang

Publikováno v: The Lancet Regional Health. Americas, Vol 8, Iss , Pp 100150- (2022)

Summary: There is growing support to reverse mass incarceration in the United States, especially in the wake of the COVID-19 pandemic. Little is known about what types and scale of community investments are most effective to support mass decarceratio

Externí odkaz: https://doaj.org/article/80705379474942a882543e2ef419d2e5

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Akademický článek

Long-Term Hypoxia Negatively Influences Ca2+ Signaling in Basilar Arterial Myocytes of Fetal and Adult Sheep

Autor: Casey Reid, Monica Romero, Stephanie B. Chang, Noah Osman, Jose L. Puglisi, Christopher G. Wilson, Arlin B. Blood, Lubo Zhang, Sean M. Wilson

Publikováno v: Frontiers in Physiology, Vol 12 (2022)

Cerebral arterial vasoreactivity is vital to the regulation of cerebral blood flow. Depolarization of arterial myocytes elicits whole-cell Ca2+ oscillations as well as subcellular Ca2+ sparks due to activation of ryanodine receptors on the sarcoplasm

Externí odkaz: https://doaj.org/article/ca2f1c78ab6c417ca7961d33da443583

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