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pro vyhledávání: '"L. Pavlíčková"'
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Autor:
Petr Hamal, Jiri Dostal, L. Pavlíčková, Tomáš Ruml, Iva Pichová, Olga Hrušková-Heidingsfeldová, Milan Souček
Publikováno v:
Journal of Clinical Microbiology. 41:712-716
The yeasts of the genus Candida are opportunistic pathogens associated with the rising incidence of life-threatening infections in immunocompromised individuals. Secretion of aspartic proteinases has been determined to be one of the virulence factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1d5bcad699215d177e6c5ee3bee0fc
https://doi.org/10.1128/jcm.41.2.712-716.2003
https://doi.org/10.1128/jcm.41.2.712-716.2003
Autor:
Ivana Křížová, Martin Hradilek, Iva Pichová, Martin Fusek, Tomáš Ruml, Milan Souček, Kateřina Brožková, L. Pavlíčková
Publikováno v:
Collection of Czechoslovak Chemical Communications. 64:130-137
In an attempt to develop effective inhibitors of Candida secreted aspartic proteinases, we have prepared a series of N-protected peptides varying in the type of scissile bond replacement, in the P and P' side chains as well as in the N- and C-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20534d9f77c8d476f40c3104ab42c438
https://doi.org/10.1135/cccc19990130
https://doi.org/10.1135/cccc19990130
Autor:
Vladimír Kostka, F. Kaprálek, Iva Pichová, Juraj Sedlacek, Vladimir Benes, S. Foundling, Petr Štrop, Milan Souček, L. Pavlíčková, M. Trávníček
Publikováno v:
International Journal of Biochemistry. 24:235-242
1. 1. The p15 gag proteinase responsible for the processing of the polyprotein precursor of the myeloblastosis associated virus was obtained by a recombinant technique in an E. coli expression system. The massive expression of the intentionally trunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32638250d961ee70c177e70030849e18
https://doi.org/10.1016/0020-711x(92)90252-v
https://doi.org/10.1016/0020-711x(92)90252-v
Autor:
Jiri Velek, Ivo Bláha, Miloslav Trávníček, L. Pavlíčková, Juraj Sedlacek, Petr Štrop, Vladimír Kostka, Jan Konvalinka, Dalibor Stys
Publikováno v:
Biochemistry. 30:3437-3443
The specificity of the p15 proteinase of myeloblastosis-associated virus (MAV) was tested with nonviral high molecular weight substrates and with synthetic peptides. Peptides with sequences spanning known cleavage sites in viral polyproteins of Rous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00f813194757d185064a8d86146dee0
https://doi.org/10.1021/bi00228a013
https://doi.org/10.1021/bi00228a013
Autor:
Martin Hradilek, Iva Pichová, Pavel Majer, Filip Majer, L. Pavlíčková, Olga Hrušková-Heidingsfeldová, Elena Dolejší
Publikováno v:
Biological chemistry. 387(9)
Secreted aspartic proteases (Saps) of pathogenicCandidaspp. represent a specific target for antifungal drug development. We synthesized a series of peptidomimetic inhibitors with different isosteric groups and modifications at individual positions an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ece9aff0eb9b110d5204a2e3a6ead5f
https://pubmed.ncbi.nlm.nih.gov/16972793
https://pubmed.ncbi.nlm.nih.gov/16972793
Autor:
Tomáš Ruml, Milan Souček, Jan Weber, Olga Hrušková-Heidingsfeldová, Iva Pichová, L. Pavlíčková, Elena Dolejší, Jiří Dostál
Publikováno v:
European journal of biochemistry. 268(9)
The frequency of Candida infections has increased in recent years and it has been accompanied by a significant rise in morbidity and mortality. The secretion of aspartic proteases by Candida spp. was demonstrated to be one of the virulence determinan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d356a96ef5494ee0b989a4758f9b48
https://pubmed.ncbi.nlm.nih.gov/11322888
https://pubmed.ncbi.nlm.nih.gov/11322888
Autor:
Dalibor Stys, Petr Štrop, Jan Urban, Olga Hrušková, L. Pavlíčková, Juraj Sedlacek, Milan Souček
Publikováno v:
Archives of biochemistry and biophysics. 298(2)
The key role of retrovirus-encoded proteinases in limited proteolysis of polyprotein precursors, a prerequisite of the formation of mature infectious virions, makes these enzymes attractive targets of specific inhibitors. A rational basis for the des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd0c805efd9fc47d1e9d22560d9f984
https://pubmed.ncbi.nlm.nih.gov/1417001
https://pubmed.ncbi.nlm.nih.gov/1417001
Autor:
Petr Štrop, Jan Konvalinka, M. Hořejší, Milan Fábry, Martin Andreánsky, Ivo Bláha, S. Foundling, L. Pavlíčková, Vladimír Kostka, J. Sedláček, I. Pichová, R. Škrabana, Jiří Velek, V. Černá
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468460148
All proteinases of avian and mammalian retroviruses belong to the family of aspartic proteinases, are of similar size and of homologous primary structure; they all act catalytically in the form of highly symmetric molecular dimers.1 Detailed studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe7e03bb7d86107b4449f31a84f1982b
https://doi.org/10.1007/978-1-4684-6012-4_68
https://doi.org/10.1007/978-1-4684-6012-4_68
Autor:
P. Štrop, L. Pavlíčková, D. Štys, M. Souček, J. Urban, O. Hrušková, F. Kaprálek, P. Ječmen, J. Sedláček, V. Kostka
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468460148
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c32d7d52c6d43e2da08f43d5afea5ad5
https://doi.org/10.1007/978-1-4684-6012-4_69
https://doi.org/10.1007/978-1-4684-6012-4_69