Zobrazeno 1 - 10
of 19
pro vyhledávání: '"L. Patrick Schenck"'
Autor:
L. Patrick Schenck, Joshua J. C. McGrath, Daphnée Lamarche, Martin R. Stämpfli, Dawn M. E. Bowdish, Michael G. Surette
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
ABSTRACT Respiratory infections are a leading cause of morbidity and mortality worldwide. Bacterial pathogens often colonize the upper respiratory tract (nose or mouth) prior to causing lower respiratory infections or invasive disease. Interactions w
Externí odkaz:
https://doaj.org/article/4b8080cc2100449f9a7fc427badf0db7
Autor:
Simon A. Hirota, Aito Ueno, Sarah E. Tulk, Helen M. Becker, L. Patrick Schenck, Mireille S. Potentier, Yan Li, Subrata Ghosh, Daniel A. Muruve, Justin A. MacDonald, Paul L. Beck
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
The pathogenesis of Crohn’s disease (CD) involves defects in the innate immune system, impairing responses to microbes. Studies have revealed that mutations NLRP3 are associated with CD. We reported previously that Nlrp3−/− mice were more susce
Externí odkaz:
https://doaj.org/article/672a27eea8bb4adcb334cb3fea64eedc
Autor:
Jonathan P. Mapletoft, Joshua J.C. McGrath, Bruce Ly, L. Patrick Schenck, Peter Y.F. Zeng, Joshua F E Koenig, Pamela Shen, Matthew F. Fantauzzi, Matthew S. Miller, Rachel Heo, Steven P. Cass, Martin R. Stämpfli, Danya Thayaparan, Puja Bagri
Publikováno v:
Mucosal Immunology. 14:1067-1076
The upper respiratory tract is highly exposed to airborne pathogens and serves as an important inductive site for protective antibody responses, including mucosal IgA and systemic IgG. However, it is currently unknown to what extent inhaled environme
Autor:
Joshua J.C. McGrath, Dawn M. E. Bowdish, L. Patrick Schenck, Martin R. Stämpfli, Michael G. Surette, Daphnée Lamarche
Publikováno v:
mSphere
mSphere, Vol 5, Iss 6 (2020)
mSphere, Vol 5, Iss 6 (2020)
The nasal microbiota is composed of species that play a role in the colonization success of pathogens, including Streptococcus pneumoniae and Staphylococcus aureus. Murine models provide the ability to explore disease pathogenesis, but little is know
Autor:
Joshua J C, McGrath, Danya, Thayaparan, Steven P, Cass, Jonathan P, Mapletoft, Peter Y F, Zeng, Joshua F E, Koenig, Matthew F, Fantauzzi, Puja, Bagri, Bruce, Ly, Rachel, Heo, L Patrick, Schenck, Pamela, Shen, Matthew S, Miller, Martin R, Stämpfli
Publikováno v:
Mucosal immunology. 14(5)
The upper respiratory tract is highly exposed to airborne pathogens and serves as an important inductive site for protective antibody responses, including mucosal IgA and systemic IgG. However, it is currently unknown to what extent inhaled environme
Autor:
Joshua J.C. McGrath, Fiona J. Whelan, Gilles Vanderstocken, Martin R. Stämpfli, Michael G. Surette, L. Patrick Schenck, Dawn M. E. Bowdish, Pamela Shen
Publikováno v:
Infection and Immunity. 85
Smokers have nasal microbiota dysbiosis, with an increased frequency of colonizing bacterial pathogens. It is possible that cigarette smoke increases pathogen acquisition by perturbing the microbiota and decreasing colonization resistance. However, i
Autor:
L P, Schenck, L Patrick, Schenck, S A, Hirota, C L, Hirota, P, Boasquevisque, S E, Tulk, Y, Li, A, Wadhwani, C T A, Doktorchik, W K, Macnaughton, P L, Beck, J A, MacDonald
Publikováno v:
Neurogastroenterology & Motility. 25:e441-e453
Background Clostridium difficile (Cdf) releases toxins (TcdA and TcdB) that damage the intestinal epithelial barrier. Ecto-5′-nucleotidase (CD73) is expressed on intestinal epithelial cells, and it is hypothesized to protect against toxin-induced e
Autor:
David Smyth, Arthur Wang, Fernando Lopes, Paul L. Beck, L. Patrick Schenck, Axinia Doering, Derek M. McKay, Jose-Luis Reyes, Christopher C. M. Waterhouse
Publikováno v:
Journal of leukocyte biology. 97(6)
Despite progress in understanding enteric inflammation, current therapies, although effective in many patients with inflammatory bowel disease (IBD), have significant side-effects, and, in many patients, it is refractory to treatment. The Src kinase
Publikováno v:
World Journal of Gastrointestinal Pathophysiology. 6:169
The impact of antibiotics on the human gut microbiota is a significant concern. Antibiotic-associated diarrhea has been on the rise for the past few decades with the increasing usage of antibiotics. Clostridium difficile infections (CDI) have become
Autor:
Paul L. Beck, James A. Cotton, Jean-Paul Motta, L. Patrick Schenck, Andre G. Buret, Simon A. Hirota
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109087 (2014)
PLoS ONE
PLoS ONE
Giardia duodenalis (syn. G. intestinalis, G. lamblia) is a predominant cause of waterborne diarrheal disease that may lead to post-infectious functional gastrointestinal disorders. Although Giardia-infected individuals could carry as much as 106 trop