Zobrazeno 1 - 10
of 2 316
pro vyhledávání: '"L. Patrick"'
Autor:
Trevor J. Gonzalez, Katherine E. Simon, Leo O. Blondel, Marco M. Fanous, Angela L. Roger, Maribel Santiago Maysonet, Garth W. Devlin, Timothy J. Smith, Daniel K. Oh, L. Patrick Havlik, Ruth M. Castellanos Rivera, Jorge A. Piedrahita, Mai K. ElMallah, Charles A. Gersbach, Aravind Asokan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Recombinant adeno-associated viral (AAV) vectors are a promising gene delivery platform, but ongoing clinical trials continue to highlight a relatively narrow therapeutic window. Effective clinical translation is confounded, at least in part
Externí odkaz:
https://doaj.org/article/d9d15ee20e5e46a9b86982294d7e7093
Autor:
H. H. Zhu, J. Zou, H. Zhang, Y. Z. Shi, S. B. Luo, N. Wang, H. Cai, L. X. Wan, B. Wang, X. D. Jiang, J. Thompson, X. S. Luo, X. H. Zhou, L. M. Xiao, W. Huang, L. Patrick, M. Gu, L. C. Kwek, A. Q. Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Here, we propose the integrated diffractive optical network for implementing parallel Fourier transforms, convolution operations and application-specific optical computing with reduced footprint and energy consumption.
Externí odkaz:
https://doaj.org/article/98354acbdf4048b48449a30ff0923548
Autor:
Zachary C. Elmore, L. Patrick Havlik, Daniel K. Oh, Leif Anderson, George Daaboul, Garth W. Devlin, Heather A. Vincent, Aravind Asokan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Adeno-associated viruses can be secreted in a pre-lytic manner as free or extracellular vesicle (EV)-associated particles. Here, Elmore et al. show that the recently identified membrane-associated accessory protein (MAAP) functions as an AAV egress f
Externí odkaz:
https://doaj.org/article/77164043657048c7a3dd23f08da5097f
Autor:
L. Patrick Schenck, Joshua J. C. McGrath, Daphnée Lamarche, Martin R. Stämpfli, Dawn M. E. Bowdish, Michael G. Surette
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
ABSTRACT Respiratory infections are a leading cause of morbidity and mortality worldwide. Bacterial pathogens often colonize the upper respiratory tract (nose or mouth) prior to causing lower respiratory infections or invasive disease. Interactions w
Externí odkaz:
https://doaj.org/article/4b8080cc2100449f9a7fc427badf0db7
Autor:
Karen C. Chung, Anushini Muthutantri, Grace G. Goldsmith, Megan R. Watts, Audrey E. Brown, Donald L. Patrick
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-23 (2024)
Abstract Background Cancer stage at diagnosis is an important prognostic indicator for patient outcomes, with detection at later stages associated with increased mortality and morbidity. The impact of cancer stage on patient-reported outcomes is poor
Externí odkaz:
https://doaj.org/article/3121e47af9874e92b59d0081de18630d
Autor:
Marjorie L. Patrick, Andrew Donini, Andrew Zogby, Christopher Morales, Michael J. O’Donnell, Sarjeet S. Gill
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Aquatic animals residing in saline habitats either allow extracellular sodium concentration to conform to environmental values or regulate sodium to lower levels. The latter strategy requires an energy-driven process to move sodium against a
Externí odkaz:
https://doaj.org/article/6fdad64a6f8e4e688623765592df0b6d
Autor:
Simon A. Hirota, Aito Ueno, Sarah E. Tulk, Helen M. Becker, L. Patrick Schenck, Mireille S. Potentier, Yan Li, Subrata Ghosh, Daniel A. Muruve, Justin A. MacDonald, Paul L. Beck
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
The pathogenesis of Crohn’s disease (CD) involves defects in the innate immune system, impairing responses to microbes. Studies have revealed that mutations NLRP3 are associated with CD. We reported previously that Nlrp3−/− mice were more susce
Externí odkaz:
https://doaj.org/article/672a27eea8bb4adcb334cb3fea64eedc