Zobrazeno 1 - 10 of 59 pro vyhledávání: '"L. Pablo Cid"'
1
Akademický článek
A new family of glutamate-gated chloride channels in parasitic sea louse Caligus rogercresseyi: A subunit refractory to activation by ivermectin is dominant in heteromeric assemblies.
Autor: Felipe Tribiños, Patricio Cuevas, Isabel Cornejo, Francisco V Sepúlveda, L Pablo Cid
Publikováno v: PLoS Pathogens, Vol 19, Iss 3, p e1011188 (2023)
Sea louse ectoparasitosis is a major threat to fish aquaculture. Avermectins such as ivermectin and emamectin have been effectively used against sea louse infestation, but the emergence of resistance has limited their use. A better understanding of t
Externí odkaz: https://doaj.org/article/69a1ea90c04a474a930ff61153c595ea
Zobrazit plný text záznamu
2
Altered phosphatidylinositol regulation of mutant inwardly rectifying K + Kir7.1 channels associated with inherited retinal degeneration disease
Autor: L. Pablo Cid, Erwin Vera, Isabel Cornejo, Francisco V. Sepúlveda, María Isabel Niemeyer
Publikováno v: The Journal of Physiology. 599:593-608
Key points Kir7.1 K+ channel expressed in retinal pigment epithelium is mutated in inherited retinal degeneration diseases. We study Kir7.1 in heterologous expression to test the hypothesis that pathological R162 mutation to neutral amino-acids resul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ffb4ce32dc2808a9b30a5ed156a3968
https://doi.org/10.1113/jp280681
Zobrazit plný text záznamu
3
Akademický článek
Cleft Palate, Moderate Lung Developmental Retardation and Early Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly Rectifying K+ Channel.
Autor: Sandra Villanueva, Johanna Burgos, Karen I López-Cayuqueo, Ka-Man Venus Lai, David M Valenzuela, L Pablo Cid, Francisco V Sepúlveda
Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0139284 (2015)
Kir7.1 is an inwardly rectifying K+ channel of the Kir superfamily encoded by the kcnj13 gene. Kir7.1 is present in epithelial tissues where it colocalizes with the Na+/K+-pump probably serving to recycle K+ taken up by the pump. Human mutations affe
Externí odkaz: https://doaj.org/article/d89a2833211d4da1ba2dcfe23db1c216
Zobrazit plný text záznamu
4
Akademický článek
Identification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fish.
Autor: Isabel Cornejo, Olga Andrini, María Isabel Niemeyer, Vanessa Marabolí, F Danilo González-Nilo, Jacques Teulon, Francisco V Sepúlveda, L Pablo Cid
Publikováno v: PLoS Pathogens, Vol 10, Iss 9, p e1004402 (2014)
Parasitic sea lice represent a major sanitary threat to marine salmonid aquaculture, an industry accounting for 7% of world fish production. Caligus rogercresseyi is the principal sea louse species infesting farmed salmon and trout in the southern he
Externí odkaz: https://doaj.org/article/9a1e2cafc05646e8a6773295611eeaf3
Zobrazit plný text záznamu
6
Akademický článek
Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.
Autor: Leandro Zúñiga, Valeria Márquez, Fernando D González-Nilo, Christophe Chipot, L Pablo Cid, Francisco V Sepúlveda, María Isabel Niemeyer
Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16141 (2011)
K(+) channels share common selectivity characteristics but exhibit a wide diversity in how they are gated open. Leak K(2P) K(+) channels TASK-2, TALK-1 and TALK-2 are gated open by extracellular alkalinization. The mechanism for this alkalinization-d
Externí odkaz: https://doaj.org/article/55ccb5c0112f492ebbbf478c5127f501
Zobrazit plný text záznamu
7
K2PTASK-2 and KCNQ1-KCNE3 K+channels are major players contributing to intestinal anion and fluid secretion
Autor: Sandra Villanueva, L. Pablo Cid, Francisca Julio-Kalajzić, Thomas J. Jentsch, Francisco V. Sepúlveda, Margarita Ojeda, Johanna Burgos
Publikováno v: The Journal of Physiology. 596:393-407
Key points K+ channels are important in intestinal epithelium as they ensure the ionic homeostasis and electrical potential of epithelial cells during anion and fluid secretion. Intestinal epithelium cAMP-activated anion secretion depends on the acti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d908c7f75d4d0086a85686aafa1da11
https://doi.org/10.1113/jp275178
Zobrazit plný text záznamu
9
A novel Kir7.1 splice variant expressed in various mouse tissues shares organisational and functional properties with human Leber amaurosis-causing mutations of this K
Autor: Francisco V. Sepúlveda, Johanna Burgos, Erwin Vera, L. Pablo Cid, Isabel Cornejo, María Isabel Niemeyer
Publikováno v: Biochemical and biophysical research communications. 514(3)
Kir7.1 is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. In the present communication we report the presence of a novel splice variant of Kir7.1 in mouse tissues including kidney, lu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dac7f327485122b90d184ac6fd1927
https://pubmed.ncbi.nlm.nih.gov/31056263
Zobrazit plný text záznamu
10
Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse
Autor: Amber R. Philp, Francisco V. Sepúlveda, Rodrigo González, L. Pablo Cid, Carlos A. Flores, Texia T. Riquelme, Pamela Millar-Büchner
Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Nearly 70% of cystic fibrosis (CF) patients bear the phenylalanine-508 deletion but disease severity differs greatly, and is not explained by the existence of different mutations in compound heterozygous. Studies demonstrated that genes other than CF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908c383939b680b703ae53123a02dfad
http://europepmc.org/articles/PMC6006244
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje