Zobrazeno 1 - 10
of 36
pro vyhledávání: '"L. P. Sashchenko"'
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stre
Externí odkaz:
https://doaj.org/article/8252af72c55b438ca49eea1bb4478b86
Publikováno v:
Doklady Biochemistry and Biophysics. 508:12-16
Abstract To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82dfd6371dca89f55de06e0cd540931a
https://doi.org/10.1134/s160767292270003x
https://doi.org/10.1134/s160767292270003x
Autor:
O. K. Ivanova, T. N. Sharapova, E. A. Romanova, L. P. Sashchenko, D. V. Yashin, G. P. Georgiev
Publikováno v:
Doklady. Biochemistry and biophysics. 506(1)
Abstract One of the basic features of immune system is the ability to sustain balance between activation and suppression of effector lymphocytes. In this process a key role belongs to the subpopulation of cells called regulatory T cells (Treg). Many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f31c57b9b29955bf9b76392c61f292f
https://pubmed.ncbi.nlm.nih.gov/36303048
https://pubmed.ncbi.nlm.nih.gov/36303048
Publikováno v:
Доклады Академии наук. 484:777-780
Tag7 (PGRP-S) is an innate immune protein that is involved in the antibacterial and antitumor defense and stimulates the maturation of cytotoxic lymphocyte subpopulations. It was found that the incubation of lymphocytes with Tag7 for 3 days promotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00af97035006fdfb7a083a79d34874cb
https://doi.org/10.31857/s0869-56524846777-780
https://doi.org/10.31857/s0869-56524846777-780
Publikováno v:
Journal of Immunology Research
Journal of Immunology Research, Vol 2018 (2018)
Journal of Immunology Research, Vol 2018 (2018)
We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea787f1a87c937b14b9d83ec6af1a3e
https://pubmed.ncbi.nlm.nih.gov/29850628
https://pubmed.ncbi.nlm.nih.gov/29850628
Publikováno v:
Biofizika. 56(5)
Some mechanisms of the antitumor action of the protein Tag7 have been considered, and three scenarios of the manifestation of cytotoxic effects during the formation of its complex with other proteins have been considered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4872ae943af612c391df1a4e34790253
https://pubmed.ncbi.nlm.nih.gov/22117442
https://pubmed.ncbi.nlm.nih.gov/22117442
Autor:
V. A. Shleptsova, E. A. Tonevitsky, T. V. Stupnikova, E. S. Grebenyuk, L. P. Sashchenko, D. A. Sakharov
Publikováno v:
Bulletin of experimental biology and medicine. 149(5)
Extracellular concentration of heat shock protein (Hsp) with a molecular weight of 70 kDa (Hsp70) rapidly increases in the serum in response to stress and returns to the basal level during recovery. Further regulation of its blood concentration is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01be6814b28a3e680e6a1cc0e957339f
https://pubmed.ncbi.nlm.nih.gov/21165407
https://pubmed.ncbi.nlm.nih.gov/21165407
Autor:
D V, Yashin, E A, Dukhanina, O D, Kabanova, T I, Luk'yanova, E A, Romanova, L P, Sashchenko, L K, Skolysheva, YuV, Shatalov, N V, Gnuchev
Publikováno v:
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 383
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f36dc67c053f8bd9fa181f19a3ee5632
https://pubmed.ncbi.nlm.nih.gov/12053572
https://pubmed.ncbi.nlm.nih.gov/12053572
Autor:
L P, Sashchenko, S V, Khaidukov, A V, Kozyr, T I, Luk'yanova, A G, Gabibov, S V, Suchkov, T V, Bobik, Z S, Alekberova, N V, Gnuchev
Publikováno v:
Doklady. Biochemistry and biophysics. 380
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e4d10ff19ff4e2bd4a5493863df54c7
https://pubmed.ncbi.nlm.nih.gov/11727552
https://pubmed.ncbi.nlm.nih.gov/11727552
Autor:
I I, Vorob'ev, N A, Ponomarenko, O M, Durova, A V, Kozyr', A V, Demin, A V, Kolesnikov, L P, Sashchenko, M Ia, Karpeĭskiĭ, A G, Gabibov
Publikováno v:
Bioorganicheskaia khimiia. 27(4)
A method for expression of an onconase gene leading to a soluble form of the protein was developed. The enzymatic and cytotoxic properties of the protein's recombinant forms were studied. Recombinant onconase with an additional N-terminal Met residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d108aec0c162acbd8bbba8ecdc7f343
https://pubmed.ncbi.nlm.nih.gov/11558259
https://pubmed.ncbi.nlm.nih.gov/11558259