Zobrazeno 1 - 10
of 31
pro vyhledávání: '"L. P. Clarke"'
Autor:
Sarah L. N. Clarke, Hannah J. Jones, Gemma C. Sharp, Kayleigh E. Easey, Alun D. Hughes, Athimalaipet V. Ramanan, Caroline L. Relton
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background There is growing concern about the long-term cardiovascular health of patients with juvenile idiopathic arthritis (JIA). In this study we assessed the association between JIA polygenic risk and cardiovascular phenotypes (cardiovas
Externí odkaz:
https://doaj.org/article/77e7c65c531d47ec83a341d578e379f4
Autor:
Sarah L. N. Clarke, Rebecca C. Richmond, Jie Zheng, Wes Spiller, Athimalaipet V. Ramanan, Gemma C. Sharp, Caroline L. Relton
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 4, Pp 363-370 (2022)
Objective Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease; however, little is known about its wider health impacts. This study explores health outcomes associated with JIA genetic liability. Methods We used publicly
Externí odkaz:
https://doaj.org/article/a6c957512e284f1eb41e43c4ac5d75a2
Autor:
Sarah L. N. Clarke, Katie S. Mageean, Henry Carlton, Gabriele Simonini, Gemma C. Sharp, Caroline L. Relton, Athimalaipet V. Ramanan
Publikováno v:
Journal of Ophthalmic Inflammation and Infection, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Background Juvenile idiopathic arthritis associated uveitis (JIA-U) is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and carries considerable risk to vision. The aim of this systematic review was to syn
Externí odkaz:
https://doaj.org/article/4a095600652645058a073796e0652847
Autor:
S. L. N. Clarke, L. Robertson, G. I. Rice, L. Seabra, T. N. Hilliard, Y. J. Crow, A. V. Ramanan
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 18, Iss 1, Pp 1-5 (2020)
Abstract Background STING-associated vasculopathy with onset in infancy (SAVI) is a type 1 interferonopathy manifesting as a pulmonary and vascular syndrome resulting from gain-of-function mutations in TMEM173, the gene encoding STING. Familial repor
Externí odkaz:
https://doaj.org/article/4a2403c2c6dd4a02ae445af674026881
Autor:
Megan Cann, Athimalaipet V. Ramanan, Andrew Crawford, Andrew D. Dick, Sarah L. N. Clarke, Fatima Rashed, Catherine M. Guly
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background There is a paucity of data on the ocular outcomes in paediatric non-infectious uveitis since the introduction of the biologic agents. The purpose of this study was to outline the clinical characteristics of children with non-infec
Externí odkaz:
https://doaj.org/article/6c62e56417a145789b54d24b147eb29f
Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis
Autor:
Srikant Ambatipudi, Gemma C. Sharp, Sarah L. N. Clarke, Darren Plant, Jonathan H. Tobias, David M. Evans, Anne Barton, Caroline L. Relton
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, a
Externí odkaz:
https://doaj.org/article/9e9e4ceedac74d9fa37d26986699aa3b
Publikováno v:
Biogeosciences, Vol 6, Iss 7, Pp 1209-1227 (2009)
Small-scale heterogeneity of biogenic carbonate elemental composition can be a significant source of error in the accurate use of element/Ca ratios as geochemical proxies. In this study ion microprobe (SIMS) profiles showed significant small-scale va
Externí odkaz:
https://doaj.org/article/16e64ea490844b89bd34204c0218c321
Publikováno v:
Biogeosciences, Vol 5, Iss 5, Pp 1245-1258 (2008)
The Mg/Ca ratios of biogenic calcite is commonly seen as a valuable palaeo-proxy for reconstructing past ocean temperatures. The temperature dependence of Mg/Ca ratios in bivalve calcite has been the subject of contradictory observations. The palaeoc
Externí odkaz:
https://doaj.org/article/c1039c9f35b04ab69165f90921f59413
Autor:
Martin L. Ashdown, Andrew P. Robinson, Steven L. Yatomi-Clarke, M. Luisa Ashdown, Andrew Allison, Derek Abbott, Svetomir N. Markovic, Brendon J. Coventry
Publikováno v:
F1000Research, Vol 4 (2015)
Complete response (CR) rates reported for cytotoxic chemotherapy for late-stage cancer patients are generally low, with few exceptions, regardless of the solid cancer type or drug regimen. We investigated CR rates reported in the literature for clini
Externí odkaz:
https://doaj.org/article/cb44d5da8b414e1dafcedc644386a587
Autor:
E. Helton, L. P. Clarke, R. Nordstrom, G. Harris, David J. Foran, Daniel L. Rubin, Joel H. Saltz, Ashish Sharma, Fred W. Prior, E. Shalley, Andriy Fedorov, C. Chennubhotla
Publikováno v:
Yearbook of Medical Informatics. 26:110-119
Summary Objectives: Precision medicine requires the measurement, quantification, and cataloging of medical characteristics to identify the most effective medical intervention. However, the amount of available data exceeds our current capacity to extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d040b94d43506171bdb9371e7cc76fe
https://doi.org/10.15265/iy-2017-041
https://doi.org/10.15265/iy-2017-041