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Akademický článek

Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL

Autor: Kallesh D. Jayappa, Craig A. Portell, Vicki L. Gordon, Brian J. Capaldo, Stefan Bekiranov, Mark J. Axelrod, L. Kyle Brett, Julia D. Wulfkuhle, Rosa I. Gallagher, Emanuel F. Petricoin, Timothy P. Bender, Michael E. Williams, Michael J. Weber

Publikováno v: Blood Advances, Vol 1, Iss 14, Pp 933-946 (2017)

Abstract: De novo resistance and rapid recurrence often characterize responses of B-cell malignancies to ibrutinib (IBR), indicating a need to develop drug combinations that block compensatory survival signaling and give deeper, more durable response

Externí odkaz: https://doaj.org/article/8971b2c6746d4ca78045d1f18e8e94de

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11 beta-hydroxysteroid dehydrogenase in vascular smooth muscle and heart: implications for cardiovascular responses to glucocorticoids

Autor: B R, Walker, J L, Yau, L P, Brett, J R, Seckl, C, Monder, B C, Williams, C R, Edwards

Publikováno v: Endocrinology. 129(6)

The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) converts the active glucocorticoid corticosterone to inactive 11-dehydrocorticosterone in the rat (or cortisol to cortisone in man), thereby protecting renal mineralocorticoid receptors f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9be5068b44683c8c4f601f64bcc166b3
https://pubmed.ncbi.nlm.nih.gov/1954906

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11β-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte

Autor: Jonathan R. Seckl, B. E. Cooke, C. R. W. Edwards, S. C. Low, Rafn Benediktsson, L. P. Brett, Joyce L.W. Yau

Publikováno v: Journal of Endocrinology. 135:53-NP

The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) catalyses the conversion of physiological glucocorticoids to inactive products, thus modifying the access of glucocorticoids to glucocorticoid and mineralocorticoid receptors. Glucocorticoids ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b395af05ae5e9dd04088cf25eb1b50
https://doi.org/10.1677/joe.0.1350053

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