Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment

Autor: Kristian Juul-Madsen, Peter Parbo, Rola Ismail, Peter L. Ovesen, Vanessa Schmidt, Lasse S. Madsen, Jacob Thyrsted, Sarah Gierl, Mihaela Breum, Agnete Larsen, Morten N. Andersen, Marina Romero-Ramos, Christian K. Holm, Gregers R. Andersen, Huaying Zhao, Peter Schuck, Jens V. Nygaard, Duncan S. Sutherland, Simon F. Eskildsen, Thomas E. Willnow, David J. Brooks, Thomas Vorup-Jensen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we rep

Externí odkaz: https://doaj.org/article/81c39ad41509420b82e48e637c1da445

Pacemaker and conduction disturbances in patients with atrial septal defect

Autor: Anne-Sif L Ovesen, Vibeke E. Hjortdal, Sebastian Udholm, Camilla Nyboe, Zarmiga Karunanithi, Diana H R Albæk

Publikováno v: Albæk, D H R, Udholm, S, Ovesen, A-S L, Karunanithi, Z, Nyboe, C & Hjortdal, V E 2020, ' Pacemaker and conduction disturbances in patients with atrial septal defect ', Cardiology in the Young, vol. 30, no. 7, pp. 980-985 . https://doi.org/10.1017/S1047951120001365

Objective:To determine the prevalence of pacemaker and conduction disturbances in patients with atrial septal defects.Design:All patients with an atrial septal defect born before 1994 were identified in the Danish National Patient Registry, and 297 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881a00db020c1ab5cad7ae7feb137dee
https://doi.org/10.1017/s1047951120001365

Airborne exposures associated with the typical use of an aerosol brake cleaner during vehicle repair work

Autor: Jerald L. Ovesen, Michael N Fries, Pamela R. D. Williams, Andrew Maier

Publikováno v: Journal of Occupational and Environmental Hygiene. 15:531-540

Many petroleum-based products are used for degreasing and cleaning purposes during vehicle maintenance and repairs. Although prior studies have evaluated chemical exposures associated with this type of work, most of these have focused on gasoline and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0583946a3685342858e3786e294195fa
https://doi.org/10.1080/15459624.2018.1467017

SorCS2 is required for BDNF-dependent plasticity in the hippocampus

Autor: Andrew H. Smith, Ulrik Bølcho, Christian Bjerggaard Vaegter, Jens R. Nyengaard, Anders Nykjaer, Kimmo Jensen, Thomas E. Willnow, S Bøggild, Simon Glerup, Simon Molgaard, L F Pedersen, Mai Marie Holm, Mads Kjolby, P L Ovesen, Hande Login, Olav M. Andersen, Anja W. Fjorback, Jose Luis Nieto-Gonzalez

Publikováno v: Glerup, S, Bolcho, U, Bøggild, S, Vaegter, C B, Smith, A H, Nieto-Gonzalez, J L, Ovesen, P L, Pedersen, L F, Fjorback, A N, Kjolby, M, Login, H, Holm, M M, Andersen, O M, Nyengaard, J R, Willnow, T E, Jensen, K, Nykjaer, A & Jensen, S M 2016, ' SorCS2 is required for BDNF-dependent plasticity in the hippocampus ', Molecular Psychiatry . https://doi.org/10.1038/mp.2016.108

SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attentio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df9bd8c77313960491ff21c27c9835d
https://doi.org/10.1038/mp.2016.108

Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice

Autor: Alvaro Puga, Andrew VonHandorf, Jerald L. Ovesen, Ying Xia, Francisco J. Sánchez-Martín, Yunxia Fan, Vinicius Carreira

Publikováno v: Toxicological Sciences. 146:52-64

Complex mixtures of environmental agents often cause mixture-specific health effects that cannot be accounted for by a single mechanism. To study the biological effects of exposure to a mixture of chromium-VI and benzo[a]pyrene (B[a]P), often found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad645de75f984cdcb528d893d397279
https://doi.org/10.1093/toxsci/kfv070