Zobrazeno 1 - 10
of 42
pro vyhledávání: '"L. Orthner"'
Publikováno v:
Blood. 86:436-443
Tissue factor (TF), a 46-kD glycoprotein receptor for coagulation factors VII and VIIa, is expressed on the surface of endothelial cells in response to a variety of agonists and is thought to play an important role in initiating the thrombosis associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e098c1609cbccbac34ab77cdb340379
https://doi.org/10.1182/blood.v86.2.436.bloodjournal862436
https://doi.org/10.1182/blood.v86.2.436.bloodjournal862436
Autor:
Henryk Lubon, Carolyn L. Orthner, William N. Drohan, Leonid Medved, Timothy K. Lee, Kenneth C. Ingham
Publikováno v:
Journal of Biological Chemistry. 270:13652-13659
Scanning microcalorimetry and spectrofluorimetry were applied to a study of the thermal stability and interaction of the modules within natural human protein C (PC) and recombinant protein C (rPC), a potential therapeutic anticoagulant expressed in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e639abb02831cec2d2e8778eee9e527
https://doi.org/10.1074/jbc.270.23.13652
https://doi.org/10.1074/jbc.270.23.13652
Autor:
Carolyn L. Orthner, Annemarie H. Ralston, Dan Gee, Randy Kent, Billy Kolen, J.D. McGriff, William N. Drohan
Publikováno v:
Vox Sanguinis. 69:309-318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f1abbbeea4b704fce55c1b1f476da3
https://doi.org/10.1159/000462862
https://doi.org/10.1159/000462862
Publikováno v:
The Journal of Immunology. 153:3664-3672
Recent studies have shown that infusion of the anticoagulant protein, activated protein C (APC), can ameliorate many of the systemic effects of endotoxemia in experimental animals, although the mechanisms in this action are unknown. We investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c29910e256993ecb54afced696a0c2c9
https://doi.org/10.4049/jimmunol.153.8.3664
https://doi.org/10.4049/jimmunol.153.8.3664
Publikováno v:
Thrombosis and Haemostasis. 72:465-474
Activated protein C (APC) is an antithrombotic serine proteinase having anticoagulant, profibrinolytic and anti-inflammatory activities. Despite its potential clinical utility, relatively little is known about its clearance mechanisms. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3ebcfe295a039037749122af3115a6a
https://doi.org/10.1055/s-0038-1648890
https://doi.org/10.1055/s-0038-1648890
Publikováno v:
Thrombosis and Haemostasis. 69:441-447
SummaryActivated protein C (APC) is a serine protease which plays an important role as a naturally occurring antithrombotic enzyme. APC, which is formed by thrombin-catalyzed limited proteolysis of the zymogen protein C, functions as an anticoagulant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d6bbf1b36303f93f45029d53c6ab73
https://doi.org/10.1055/s-0038-1651630
https://doi.org/10.1055/s-0038-1651630
Publikováno v:
Biotechnology and Bioengineering. 39:1013-1023
This study demonstrates that masking the Feb regions of a monoclonal antibody (Mab) with synthetic antigens prior to covalent immobilization efficiency. Water-soluble adducts of poly(2-methyloxazoline) polymers and a synthetic-peptide epitope for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206e2c8e70f66a921a75a5b3eb7047b6
https://doi.org/10.1002/bit.260391005
https://doi.org/10.1002/bit.260391005
Publikováno v:
Blood. 86(2)
Tissue factor (TF), a 46-kD glycoprotein receptor for coagulation factors VII and VIIa, is expressed on the surface of endothelial cells in response to a variety of agonists and is thought to play an important role in initiating the thrombosis associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16d45c3680b2fdbdc3a30001d11e121b
https://pubmed.ncbi.nlm.nih.gov/7605983
https://pubmed.ncbi.nlm.nih.gov/7605983
Autor:
J.D. McGriff, Randy Kent, Dan M. Gee, Annemarie H. Ralston, Carolyn L. Orthner, William N. Drohan, Billy L. Kolen
Publikováno v:
Vox sanguinis. 69(4)
Activated protein C (APC) is a highly specific serine proteinase which functions as an important naturally occurring antithrombotic enzyme. APC also has anti-inflammatory properties. We have developed a large-scale process for the production of APC f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38aea291ebe0bf4a43cfc6118a5c270d
https://pubmed.ncbi.nlm.nih.gov/8751300
https://pubmed.ncbi.nlm.nih.gov/8751300
Publikováno v:
Thrombosis and haemostasis. 72(3)
Activated protein C (APC) is an antithrombotic serine proteinase having anticoagulant, profibrinolytic and anti-inflammatory activities. Despite its potential clinical utility, relatively little is known about its clearance mechanisms. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a4f9434f4552514d3f3ea276c5242f4
https://pubmed.ncbi.nlm.nih.gov/7855799
https://pubmed.ncbi.nlm.nih.gov/7855799