Zobrazeno 1 - 10
of 520
pro vyhledávání: '"L. Nutt"'
Autor:
Yuichi Saito, Akihito Harada, Miho Ushijima, Kaori Tanaka, Ryota Higuchi, Akemi Baba, Daisuke Murakami, Stephen L. Nutt, Takashi Nakagawa, Yasuyuki Ohkawa, Yoshihiro Baba
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The differentiation of B cells into plasma cells is associated with substantial transcriptional and epigenetic remodeling. H3.3 histone variant marks active chromatin via replication-independent nucleosome assembly. However, its role in plas
Externí odkaz:
https://doaj.org/article/00f2e6ab5dc543d1a108045a01dd92fc
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/8ec940468327473da236c2641647c114
Autor:
Cindy Audiger, Yacine Laâbi, Junli Nie, Leonie Gibson, Julie Wilson-Annan, Phillip Brook-Carter, Andrew Kueh, Alan W. Harris, Shalin Naik, Stephen L. Nutt, Andreas Strasser, Jerry M. Adams, Philippe Bouillet, Michaël Chopin
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114159- (2024)
Summary: The traditional view of hematopoiesis is that myeloid cells derive from a common myeloid progenitor (CMP), whereas all lymphoid cell populations, including B, T, and natural killer (NK) cells and possibly plasmacytoid dendritic cells (pDCs),
Externí odkaz:
https://doaj.org/article/c89909ecc3fe477ea2e87a7d2dff8850
Autor:
Yexuan Deng, Sarah T. Diepstraten, Margaret A. Potts, Göknur Giner, Stephanie Trezise, Ashley P. Ng, Gerry Healey, Serena R. Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J. Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S. Alexander, Jane E. Visvader, Stephen L. Nutt, Andreas Strasser, Benjamin Haley, Quan Zhao, Gemma L. Kelly, Marco J. Herold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Modelling of aggressive lymphomas, such as double hit lymphoma, has been challenging. Here the authors engineer a CRISPR activation mouse to enable the generation of these aggressive lymphomas and identify the pro-survival BCL-2 protein A1 as a venet
Externí odkaz:
https://doaj.org/article/a6a1367d102e4deb8dbd0ddb559ac31c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Dendritic cells (DCs) are sentinel immune cells that form a critical bridge linking the innate and adaptive immune systems. Extensive research addressing the cellular origin and heterogeneity of the DC network has revealed the essential role played b
Externí odkaz:
https://doaj.org/article/9671f8d653944420b783db68c2395247
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional repressor that is of fundamental importance across species, as evident by its evolutionary conservation spanning fish, amphibians, birds, mice and humans. Inde
Externí odkaz:
https://doaj.org/article/b7e4ccf302b7414183b945ad5c984fd6
Autor:
Stephanie Trezise, Isabella Y. Kong, Edwin D. Hawkins, Marco J. Herold, Simon N. Willis, Stephen L. Nutt
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHumoral immunity depends on the differentiation of B cells into antibody secreting cells (ASCs). Excess or inappropriate ASC differentiation can lead to antibody-mediated autoimmune diseases, while impaired differentiation results in immuno
Externí odkaz:
https://doaj.org/article/57eb21cc2404438bab0ee3cd1555bae6
Autor:
Hema Preethi Subas Satish, Kathleen Zeglinski, Rachel T. Uren, Stephen L. Nutt, Matthew E. Ritchie, Quentin Gouil, Ruth M. Kluck
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Despite their common use in research, monoclonal antibodies are currently not systematically sequenced. This can lead to issues with reproducibility and the occasional loss of antibodies with loss of cell lines. Hybridoma cell lines have been the pri
Externí odkaz:
https://doaj.org/article/d09881d450954d0ba72fb3d3ec386a6c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since their discovery, innate lymphoid cells (ILCs) have been described as the innate counterpart of the T cells. Indeed, ILCs and T cells share many features including their common progenitors, transcriptional regulation, and effector cytokine secre
Externí odkaz:
https://doaj.org/article/799f186351f641218276ce8d3d41f8d2
Autor:
Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt, Warren S. Alexander
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically c
Externí odkaz:
https://doaj.org/article/6cd266dc641c4e128ba4ff9c8fb14771