Zobrazeno 1 - 10
of 134
pro vyhledávání: '"L. Noronha-Blob"'
Publikováno v:
The Journal of Immunology. 150:3397-3403
Endotoxin challenge causes metabolic dysfunction mediated by TNF, and sequestration of leukocytes. NPC 15669, N-carboxy-L-leucine, N-[2,7-dimethylfluoren-9-yl)methyl] ester, inhibits leukocyte recruitment into inflammatory lesions in animals, and inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::620765da770c00e1c2379530f6c08371
https://doi.org/10.4049/jimmunol.150.8.3397
https://doi.org/10.4049/jimmunol.150.8.3397
Publikováno v:
Life Sciences. 46:1223-1231
The potency and selectivity of (-)cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1, 5 benzothia]epin-4-(5H) one HCl (BTM-1086) for muscarinic receptor subtypes was compared in functional assay systems, in guinea pig peripheral tissues, to kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0be7291f259619c20635264902ae1a76
https://doi.org/10.1016/0024-3205(90)90497-f
https://doi.org/10.1016/0024-3205(90)90497-f
Autor:
R. C. Hanson, J. R. Connor, R. H. Erickson, P. V. Kaplita, J. A. Schenden, R. P. Hicks, M. E. Abreu, L. Noronha‐Blob, J. W. Ferkany
Publikováno v:
Drug Development Research. 20:429-443
The chemical synthesis of 8-aryl-1,3-dialkyl derivatives of xanthine and the ability of these compounds to interact with adenosine A1 and A2 receptors in vitro (in receptor binding, biochemical, and physiological assays) are described. NPC 205 (1,3-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f0e43833cff00988a15dbab5831263a
https://doi.org/10.1002/ddr.430200403
https://doi.org/10.1002/ddr.430200403
Publikováno v:
Agents and Actions. 39:C125-C127
The effects of coadministration of NPC 17761 (D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Hype (transthiophenyl)-Oic-Arg), a potent bradykinin antagonist, and NPC 15669 (N-[9H-(2,7-dimethylfluoren-9-yl-methoxy)carbonyl]-L-leucine), a leukocyte recruitment inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861b04b72bd8bd67e7813a4cb464a5cc
https://doi.org/10.1007/bf01972742
https://doi.org/10.1007/bf01972742
Autor:
R E, Howell, K D, Laemont, M P, Kovalsky, V C, Lowe, P P, Waid, W J, Kinnier, L, Noronha-Blob
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(2)
The need for a smooth muscle-selective muscarinic antagonist that could provide oral bronchodilator activity with minimal side effects has led to the discovery of 3-(4-benzyl-piperazinyl)-1-cyclobutyl-1-hydroxy-1-phenyl-2-propanone (NPC-14695). Orall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab9bbdcab7c7618809fabb53efa546fe
https://pubmed.ncbi.nlm.nih.gov/8071847
https://pubmed.ncbi.nlm.nih.gov/8071847
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 267(2)
N-[9H-(2,7-dimethylfluoren-9-ylmethoxy)carbonyl]-L-leucine (NPC 15669), a leukocyte recruitment inhibitor, was investigated for its ability to enhance survival in a rat model of sepsis, fecal peritonitis. Infusion of NPC 15669 (3 mg kg-1 hr-1 i.v.) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7981d10343fcb187205e030575666d0f
https://pubmed.ncbi.nlm.nih.gov/8246139
https://pubmed.ncbi.nlm.nih.gov/8246139
Autor:
L. Noronha-Blob, V. C. Lowe
Publikováno v:
Agents and actions.
The therapeutic efficacy of the leukocyte recruitment inhibitor, NPC 15669 (N-[9H-(2,7-dimethylfluoren-9-yl-methoxy)carbonyl]-L-leucine), was evaluated through the time course of acetic acid colitis in rats. Intrarectal (i.r.) administration of dilut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6083a4a96c648409c70d02bf8aee15d9
https://pubmed.ncbi.nlm.nih.gov/8273594
https://pubmed.ncbi.nlm.nih.gov/8273594
Autor:
V. C. Lowe, L. Noronha-Blob
Publikováno v:
Agents and actions.
An orally active leukocyte recruitment inhibitor, NPC 16570 (N-[9H-fluoren-9-ylethoxycarbonyl]-4-aminobenzoic acid), was evaluated in experimental allergic encephalomyelitis (EAE) in rats. The mean time of disease onset in control animals was 12 +/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b277b592ee98752c7e05de7d481a792e
https://pubmed.ncbi.nlm.nih.gov/8273595
https://pubmed.ncbi.nlm.nih.gov/8273595
Autor:
R M, Burch, J R, Connor, J M, Bator, M, Weitzberg, K, Laemont, L, Noronha-Blob, J P, Sullivan, L R, Steranka
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 263(3)
NPC 15669, N-carboxy-L-leucine,N-[(2,7-dimethylfluoren-9-yl)methyl]ester, has been shown to inhibit several inflammatory reactions that depend upon recruitment of neutrophils into the primary lesion. In the present study we examined the effects of NP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aafe77fdfb38086775fca20a4626eb97
https://pubmed.ncbi.nlm.nih.gov/1469649
https://pubmed.ncbi.nlm.nih.gov/1469649
Publikováno v:
European journal of pharmacology. 201(2-3)
The affinity and selectivity of racemic terodiline (N-tert-butyl-1-methyl-3,3-diphenylpropylamine HCl) for muscarinic receptor subtypes was determined from functional responses of rabbit vas deferens (M1), guinea pig atria (M2) and bladder detrusor m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc214b1c3c3056b85d25f0e49c90044c
https://pubmed.ncbi.nlm.nih.gov/1724648
https://pubmed.ncbi.nlm.nih.gov/1724648