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Akademický článek

Omics data integration suggests a potential idiopathic Parkinson’s disease signature

Autor: Alise Zagare, German Preciat, Sarah. L. Nickels, Xi Luo, Anna S. Monzel, Gemma Gomez-Giro, Graham Robertson, Christian Jaeger, Jafar Sharif, Haruhiko Koseki, Nico J. Diederich, Enrico Glaab, Ronan M. T. Fleming, Jens C. Schwamborn

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)

Abstract The vast majority of Parkinson’s disease cases are idiopathic. Unclear etiology and multifactorial nature complicate the comprehension of disease pathogenesis. Identification of early transcriptomic and metabolic alterations consistent acr

Externí odkaz: https://doaj.org/article/1c777ab6bc7a41ed91833568c4533468

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Akademický článek

Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration

Autor: Bárbara Mendes-Pinheiro, Jonas Campos, Ana Marote, Carina Soares-Cunha, Sarah L. Nickels, Anna S. Monzel, Jorge R. Cibrão, Eduardo Loureiro-Campos, Sofia C. Serra, Sandra Barata-Antunes, Sara Duarte-Silva, Luísa Pinto, Jens C. Schwamborn, António J. Salgado

Publikováno v: Cells, Vol 12, Iss 21, p 2565 (2023)

Parkinson’s disease (PD) is the most common movement disorder, characterized by the progressive loss of dopaminergic neurons from the nigrostriatal system. Currently, there is no treatment that retards disease progression or reverses damage prior t

Externí odkaz: https://doaj.org/article/d9ee2e845ba143418fd7dbee34549f1f

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Akademický článek

The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1

Publikováno v: Cell Reports, Vol 37, Iss 3, Pp 109864- (2021)

Summary: Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in a

Externí odkaz: https://doaj.org/article/2b9fa19fd71645ae8efd92a4e547da7e

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Akademický článek

Soil Carbon Stabilization Under Coniferous, Deciduous and Grass Vegetation in Post-mining Reclaimed Ecosystems

Autor: Meghan C. L. Nickels, Cindy E. Prescott

Publikováno v: Frontiers in Forests and Global Change, Vol 4 (2021)

Vegetation plays an important role in determining soil organic carbon (SOC) stocks, and influences the mechanisms through which SOC is stabilized within the soil. The type of vegetation selected for use in reclamation may therefore influence the accu

Externí odkaz: https://doaj.org/article/a3b318eb37864d958a8855657a960258

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Akademický článek

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

Autor: Na Luo, Mellissa J. Nixon, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Susan R. Opalenik, Huili Li, Cynthia A. Zahnow, Michael L. Nickels, Fei Liu, Mohammed N. Tantawy, Melinda E. Sanders, H. Charles Manning, Justin M. Balko

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Immunotherapy often fails as a single option treatment in cancer. Here, the authors show that targeting of DNA methyltransferases, such as DNMT1, can potentiate anti-tumor immunity and response to checkpoint inhibition by increasing MHC gene expressi

Externí odkaz: https://doaj.org/article/ffb91a393be74576a78dffc6f8e78041

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