Zobrazeno 1 - 10
of 35
pro vyhledávání: '"L. N. Shitov"'
Autor:
L. N. Shitov, Yu. A. Dzhurko, R. V. Drai, I. E. Makarenko, A. L. Khokhlov, L. A. Khozova, O. V. Afonkina, Yu. A. Sevastyanova, N. A. Vasilenko, A. A. Abramova
Publikováno v:
Acta Biomedica Scientifica, Vol 4, Iss 1, Pp 93-101 (2019)
Aims: adaptation and validation of the ELISA method insulin glargine determination for the pharmacokinetic study, practical approval in the biosimilars clinical trial.Materials and methods. Serum insulin glargine determination was measured using a co
Externí odkaz:
https://doaj.org/article/a41eb306288644d4abb8cd179e27d865
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 2, Pp 246-250 (2019)
This article describes main methods of preventing degradation of chemically unstable drugs and their metabolites in biological fluids during storage after collection from patients. It is necessary for accurate quantitative determination of these comp
Externí odkaz:
https://doaj.org/article/7dc49d00c0c54b598981abf904c2fbd1
Publikováno v:
Acta Biomedica Scientifica, Vol 3, Iss 5, Pp 106-115 (2018)
The approaches to bioanalytical method development for determination of substances which contain unstable functional groups in the structure are described. The oxidation and the hydrolysis are main causes of the decomposition of substances in biologi
Externí odkaz:
https://doaj.org/article/9dd78bef457d4735a876f2f5642c7051
Autor:
A. L. Khokhlov, Yu. A. Dzhurko, L. N. Shitov, I. I. Yaichkov, A. M. Shitova, L. A. Khozova, A. E. Miroshnikov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 57-62 (2017)
Pharmacokinetic study of prolonged release capsules of mebeverine was carried out on 24 volunteers. It is known that the drug substance is completely metabolized due to first-pass effect. Therefore, pharmacokinetic parameters of the main metabolites
Externí odkaz:
https://doaj.org/article/cdee0a7fa9e84875b221c6386f6b6c11
Autor:
A. L. Khokhlov, I. I. Yaichkov, A. M. Shitova, L. N. Shitov, Yu. A. Dzhurko, A. E. Miroshnikov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 3-8 (2016)
In a single-dose, two-treatment, two-period, two-sequence crossover study with a 14-days washout period was carried out the bioequivalence study of two tablet coated formulation of mycophenolic acid that given to 48 volunteers in equal doses (dosage
Externí odkaz:
https://doaj.org/article/85b20a8c0e414d1f884f18a354564fbe
Autor:
A. L. Khokhlov, E. G. Lileeva, O. A. Sinitsyna, S. A. Speshilova, S. M. Demarina, L. N. Shitov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 37-43 (2014)
In the review of the main problems holding bioanalytical part of bioequivalence studies of medicines in Russia. The analysis of the major causes of failure when performing studies of bioequivalence and pharmacokinetics.
Externí odkaz:
https://doaj.org/article/ef594862dbe04de49c95a9b6c6ccc8bf
Publikováno v:
Acta Biomedica Scientifica, Vol 3, Iss 5, Pp 106-115 (2018)
The approaches to bioanalytical method development for determination of substances which contain unstable functional groups in the structure are described. The oxidation and the hydrolysis are main causes of the decomposition of substances in biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771f3c1df3624471045a3ac69da96d52
https://www.actabiomedica.ru/jour/article/view/715
https://www.actabiomedica.ru/jour/article/view/715
Autor:
A. E. Miroshnikov, Khokhlov Al, V. N. Shabrov, Miroslav Ryska, V. Kubeš, Yu. A. Dzhurko, A. M. Shitova, I. I. Yaichkov, L. N. Shitov
Publikováno v:
Pharmaceutical Chemistry Journal. 51:504-507
A new rapid and accurate method for determining the mycophenolic acid concentration in human blood plasma using HPLC with tandem mass-spectrometric detection (HPLC-MS/MS) and deproteinization for sample preparation was developed. The method was valid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b55fa498056c51e2973fab82f44c2f
https://doi.org/10.1007/s11094-017-1643-y
https://doi.org/10.1007/s11094-017-1643-y
Publikováno v:
Journal of Volgograd State Medical University. 14:105-108
We developed a rapid and sensitive method for quantifying plasma concentrations of methyldopa using HPLC-MS/MS. The range of concentration measurements was 0,02-3,00 цд/ml. The method was applied for pharmacokinetic study of methyldopa tablet formu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c3f5e49f4554c0778813c7078ce3a8
https://doi.org/10.19163/1994-9480-2017-3(63)-105-108
https://doi.org/10.19163/1994-9480-2017-3(63)-105-108
Autor:
E. E. Tungusova, V. K. Kurochkin, Yu. L. Kruglyak, Yu. N. Stepanov, A. M. Kvetnyi, I. I. Kashnikova, V. S. Dobryanskii, L. N. Shitov
Publikováno v:
Pharmaceutical Chemistry Journal. 31:584-588
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4451ec66bcb671fa58692cc84146b322
https://doi.org/10.1007/bf02464274
https://doi.org/10.1007/bf02464274