Výsledky vyhledávání - "L. N. Liubchenko"

The prognostic value of tumor PD-L1 status in patients with metastatic prostate cancer

Autor: V. B. Matveev, A. A. Kirichek, V. M. Safronova, N. V. Kokosadze, O. A. Khalmurzaev, B. Sh. Kamolov, L. N. Liubchenko

Publikováno v: Onkourologiâ, Vol 15, Iss 1, Pp 57-65 (2019)

Background. New potential biomarker for patients with metastatic hormone-naive prostate cancer (PCa) might be detection of programmed death ligand 1 (PD-L1) expression in tumor which is associated with worsened results of treatment and decreased surv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f74cbfca21e12ed099dd0d9ab59f2e8
https://doi.org/10.17650/1726-9776-2019-15-1-57-65

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[Genotyping of BRCA1, BRCA2 and CHEK2 germline mutations in Russian breast cancer patients using diagnostic biochips]

Autor: T V, Nasedkina, O E, Gromyko, M A, Emel'ianova, E O, Ignatova, T P, Kazubskaia, S M, Portnoĭ, A S, Zasedatelev, L N, Liubchenko

Publikováno v: Molekuliarnaia biologiia. 48(2)

Germline mutations of BRCA1/2 genes cause the predisposition of their carriers to breast or/and ovary cancers (BC or/and OC) during the lifetime. Identification of these mutations is a basis of molecular diagnosis for BC susceptibility. Rapid genotyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d16b478fb714f2798969aa0dd539c07f
https://pubmed.ncbi.nlm.nih.gov/25850293

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[Detection of KRAS mutations in tumor cells using biochips]

Autor: M A, Emel'ianova, F A, Amosenko, A V, Chudinov, S A, Surzhikov, T P, Kazubskaia, L N, Liubchenko, T V, Nasedkina

Publikováno v: Molekuliarnaia biologiia. 45(5)

Somatic mutations in the KRAS gene are important markers of some types of tumors, for example, pancreatic cancer, and may be useful in early diagnostics. A biochip has been developed which allows determining most frequent mutations in 12, 13 and 61 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99e77723fda8f4e2a1ee176fec7966f9
https://pubmed.ncbi.nlm.nih.gov/22393783

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[Li-Fraumeni syndrome: clinico-molecular diagnostics and medico-genetic counseling]

Autor: L N, Liubchenko

Publikováno v: Vestnik Rossiiskoi akademii meditsinskikh nauk. (12)

Li-Fraumeni syndrome (sarcoma family syndrome, OMIM 151623) is a rare clinically and genetically hetergoeneous autosomal dominant disorder characterized by the evolvement and accumulation of soft-tissue osteogenic sarcomas in members of a family, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88653274699991ed1dc646f0ced6335c
https://pubmed.ncbi.nlm.nih.gov/22379889

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[Bystander effect development in human mesenchymal stem cells after exposure to adaptive dose of X-radiation]

Autor: A V, Ermakov, M S, Kon'kova, S V, Kostiuk, T D, Smirnova, L V, Kameneva, R V, Veĭko, I Iu, Kubasova, L N, Liubchenko, N N, Veĭko

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 50(1)

Transposition and mutual approaching of pericentromeric loci 1q12 of homological chromosomes from the nuclear membrane towards the nuclear centre as well as activation of the chromosomal nucleolus-forming regions (NFR) are observed in human mesenchym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c987bd0ef0ae09f3c0052e74a886e9a
https://pubmed.ncbi.nlm.nih.gov/20297680

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[Analysis of BRCA1/2 and CHEK2 mutations in ovarian cancer and primary multiple tumors involving the ovaries. Patients of Russian population using biochips]

Autor: O E, Fedorova, L N, Liubchenko, Iu G, Paiadini, T P, Kazubskaia, F A, Amosenko, R F, Gar'kavtseva, A S, Zasedatelev, T V, Nasedkina

Publikováno v: Molekuliarnaia biologiia. 41(1)

Ovarian cancer (OC) is one of the leading cause of cancer death in women. Inherited BRCA1 and BRCA2 mutations strikingly increase OC risk (with lifetime risk estimates ranging at 10-60%). Mutation 1100delC in CHEK2 gene was shown to be associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d37a1985b505e20530b64e6529892b9
https://pubmed.ncbi.nlm.nih.gov/17380889

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[Analysis of polymorphic variants of gene GIPC1 CGG repeats in healthy individuals and in patients with breast cancer and non-small cell lung cancer]

Autor: D S, Mikhaĭlenko, L N, Liubchenko, I B, Zborovskaia, V V, Strel'nikov, D V, Zaletaev

Publikováno v: Genetika. 41(9)

The GIPC1 gene product promotes clustering of some transmembrane receptors, including those involved in carcinogenesis, and protects them against ubiquitin-dependent degradation. The 5' untranslated region of GIPC1 contains a polymorphic trinucleotid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e1112be4cbf7a00769cfd498f008ca8
https://pubmed.ncbi.nlm.nih.gov/16240642

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[Population genetic analysis of the association between the BRCA1 and P53 gene polymorphisms and the risk of sporadic breast cancer]

Autor: V A, Tarasov, M M, Aslanian, E S, Tsyrendorzhieva, R F, Gar'kavtseva, L N, Liubchenko, Iu P, Altukhov, V A, Mel'nik

Publikováno v: Genetika. 41(8)

Polymorphism of two tumor-suppressor genes, BRCA1 and P53, was examined. DNA was extracted from blood leukocytes of the women affected with breast cancer (N = 151) and of the women with no clinical symptoms of tumor diseases (N = 191). Typing of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9cea26811c6da2a4b17dd88899850857
https://pubmed.ncbi.nlm.nih.gov/16161633

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[The association of NAT2 polymorphisms with sporadic breast cancer]

Autor: V V, Artamonov, L N, Liubchenko, M A, Shabanov, M V, Nemtsova, D V, Zaletaev

Publikováno v: Molekuliarnaia biologiia. 38(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f834b4f349dc12f49330cea3bcaacbe
https://pubmed.ncbi.nlm.nih.gov/15285615

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[Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer]

Autor: V V, Artamonov, L N, Liubchenko, M A, Shabanov, O V, Babenko, M V, Nemtsova, D V, Zaletaev

Publikováno v: Molekuliarnaia biologiia. 37(6)

Polymorphic alleles of CYP17 and CYP19, which are involved in estrogen biosynthesis, were tested for association with breast cancer (BC). Microsatellite (TTTA)n and 3-bp deletion of CYP19 and single-nucleotide polymorphism T27C of CYP17 were analyzed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b65c56550df884339919b8d8743717e0
https://pubmed.ncbi.nlm.nih.gov/14714492

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