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of 49
pro vyhledávání: '"L. N. Grinkevich"'
Autor:
L. N. Grinkevich
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 24, Iss 8, Pp 885-896 (2020)
The mechanisms of long-term memory formation and ways to improve it (in the case of its impairment) remain an extremely difficult problem yet to be solved. Over the recent years, much attention has been paid to microRNAs in this regard. MicroRNAs are
Externí odkaz:
https://doaj.org/article/93b6917300d747c3bc65e726d705e222
Autor:
L. N. Grinkevich, T. G. Zachepilo
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 22, Iss 5, Pp 606-610 (2018)
Epigenetic mechanisms are commonly known to underlie memory formation. Presently, scientists’ attention is focused on changes in the levels of histone modifications (mainly acetylation and methylation) in the chromatin of CNS cells tested in variou
Externí odkaz:
https://doaj.org/article/be963913030a4fe78b3293313749e370
Autor:
L. N. Grinkevich, O. V. Vorobiova
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 20, Iss 2, Pp 262-268 (2016)
Epigenetic modifications are studied intensively to understand mechanisms of long-term memory. We have shown that histone H3 methylation is important for the defense reflexes formation in the mollusk Helix lucorum. We suggested that these epigenetic
Externí odkaz:
https://doaj.org/article/6d733b8d297a473cab17345cbfad9948
Autor:
O. V. Vorobiova, L. N. Grinkevich
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 18, Iss 2, Pp 345-353 (2015)
The major tasks of neurobiology include the understanding of mechanisms governing long-term memory formation and search for means to improve memory. Animals with dysfunction of the serotonergic system are a convenient model for investigation of memor
Externí odkaz:
https://doaj.org/article/c7f975a3bc344b49a13c0d2eabfa513f
Autor:
L. N. Grinkevich, O. V. Vorobiova
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 18, Iss 2, Pp 298-307 (2015)
Epigenetic mechanisms controlling long-term memory formation are a promising field in neurobiology. They include posttraslational histone modifications, which lead to chromatin remodeling and thereby influences gene expression involved in learning. M
Externí odkaz:
https://doaj.org/article/ef48ced2a0be49e1b35c795b961b7898
Autor:
L. N. Grinkevich, O. V. Vorobiova
Publikováno v:
Russian Journal of Genetics: Applied Research. 7:273-280
The epigenetic modifications of histones have been studied intensively to understand the mechanisms of long-term memory. Previously, we have shown that histone H3 methylation at the activation (H3K4me3) and inhibition (H3K9me2) sites plays an importa
Autor:
L. N. Grinkevich, O. V. Vorobiova
Publikováno v:
Russian Journal of Genetics: Applied Research. 4:526-532
Epigenetic mechanisms of the long-term memory formation are a promising field in neurobiology. They include the posttranslational histone modifications, which leads to the chromatin remodeling and thereby influences the gene expression involved in le
Autor:
L. N. Grinkevich
Publikováno v:
Neuroscience and Behavioral Physiology. 44:571-575
Post-translational modification of histones plays in important role in chromatin remodeling and is involved in regulating gene expression during the formation of long-term memory. While histone acetylation and phosphorylation have been studied intens
Autor:
L. N. Grinkevich
Publikováno v:
Neuroscience and Behavioral Physiology. 44:200-213
The most urgent problem in neurobiology is the search for the mechanisms underlying long-term memory. Gene expression has been shown to be needed for long-term memory to form. Which genes are expressed and how their expression is regulated are subjec
Autor:
L. N. Grinkevich
Publikováno v:
Bulletin of experimental biology and medicine. 163(4)
Consolidation of the conditioned food aversion response in Helix lucorum was associated with induction of histone H3 acetylation and methylation. We hypothesized that not only activatory, but also inhibitory p38 MARK-mediated pathways are involved in