Zobrazeno 1 - 10
of 42
pro vyhledávání: '"L. Motola"'
Publikováno v:
Journal of Forensic Sciences. 65:1698-1703
Dermestid beetles (Dermestes maculatus De Geer 1774) are small carrion insects characterized by a rounded or oval-shaped body and white abdomen with black markings. Given their natural propensity to consume soft tissue throughout various stages of de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a804a2cf2424a7cd378dccb6948e1a
https://doi.org/10.1111/1556-4029.14470
https://doi.org/10.1111/1556-4029.14470
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal PermeabilitySummary
Autor:
Jay Luther, John J. Garber, Hamed Khalili, Maneesh Dave, Shyam Sundhar Bale, Rohit Jindal, Daniel L. Motola, Sanjana Luther, Stefan Bohr, Soung Won Jeoung, Vikram Deshpande, Gurminder Singh, Jerrold R. Turner, Martin L. Yarmush, Raymond T. Chung, Suraj J. Patel
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 2, Pp 222-232.e2 (2015)
Background & Aims: Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. Numerous studies have inves
Externí odkaz:
https://doaj.org/article/af64a40e688a4485a116866d0e616577
Autor:
Alan C. Mullen, Bryan C. Fuchs, Joshua V. Pondick, Irina Bronova, Yusuf A. Hannun, Raymond T. Chung, Chan Zhou, Sarani Ghoshal, Samuel R. York, Nicolas Coant, Evgeny Berdyshev, Jennifer Y. Chen, Cungui Mao, Jae Kyo Yi, Benjamin Newcomb, Daniel L. Motola, Kenneth K. Tanabe
Publikováno v:
Scientific Reports
Activation of hepatic stellate cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-differentiation of quiescent HSCs to HSC myofibroblasts, which secrete extracellular matrix proteins responsible for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae837f0af1a95517cc8402e02c8c133a
Autor:
Andrew Yang, Raymond T. Chung, Esperance A. Schaefer, Cynthia Brisac, Lee F. Peng, Christina Mark, Daniel L. Motola, Dahlene N. Fusco, Clary B. Clish, Shadi Salloum, Amy Deik, Wenyu Lin, James Meixiong
Publikováno v:
World Journal of Gastroenterology
AIM To characterize the role of apolipoprotein B100 (apoB100) in hepatitis C viral (HCV) infection. METHODS In this study, we utilize a gene editing tool, transcription activator-like effector nucleases (TALENs), to generate human hepatoma cells with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe289c8b830687e0848f65b7b8715570
https://pubmed.ncbi.nlm.nih.gov/28018102
https://pubmed.ncbi.nlm.nih.gov/28018102
Autor:
Alan C. Mullen, Raymond T. Chung, Jennifer Y. Chen, Chan Zhou, Samuel R. York, Daniel L. Motola, Joshua V. Pondick
Publikováno v:
Genome Medicine
Background Hepatic fibrosis is the underlying cause of cirrhosis and liver failure in nearly every form of chronic liver disease, and hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Long noncoding RNAs (lncRNAs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82d76cba9b110848b9380f501f8938a
http://europepmc.org/articles/PMC4804564
http://europepmc.org/articles/PMC4804564
Autor:
David J. Mangelsdorf, Yidong Shen, Lilia Magomedova, Joshua Wollam, Adam Antebi, Daniel L. Motola, Carolyn L. Cummins, Veerle Rottiers, Daniel B. Magner
Publikováno v:
Aging Cell. 10:879-884
Summary Bile acids are cholesterol-derived signaling molecules that regulate mammalian metabolism through sterol-sensing nuclear receptor transcription factors. In C. elegans, bile acid-like steroids called dafachronic acids (DAs) control development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e28d75c71a8a8307dcafdd14fab52cb
https://doi.org/10.1111/j.1474-9726.2011.00733.x
https://doi.org/10.1111/j.1474-9726.2011.00733.x
Autor:
H. Eric Xu, Daniel L. Motola, David J. Mangelsdorf, Kamalesh K. Sharma, Zhu Wang, John M. Hawdon, Xin Gao, Richard J. Auchus, James B. Lok, Aoife Conneely, Kelly Suino-Powell, X. Edward Zhou, Steven A. Kliewer, Craig M. Ogata
Publikováno v:
Proceedings of the National Academy of Sciences. 106:9138-9143
Nematode parasitism is a worldwide health problem resulting in malnutrition and morbidity in over 1 billion people. The molecular mechanisms governing infection are poorly understood. Here, we report that an evolutionarily conserved nuclear hormone r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b54a083cca1538c368e87c6ce0e0ca5
https://doi.org/10.1073/pnas.0904064106
https://doi.org/10.1073/pnas.0904064106
Autor:
Adam Antebi, David J. Mangelsdorf, Dongling Li, Daniel L. Motola, Carolyn L. Cummins, Birgit Gerisch, Hans Lehrach, Veerle Rottiers
Publikováno v:
Proc Natl Acad Sci U S A
Broad aspects of Caenorhabditis elegans life history, including larval developmental timing, arrest at the dauer diapause, and longevity, are regulated by the nuclear receptor DAF-12. Endogenous DAF-12 ligands are 3-keto bile acid-like steroids, call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cbf348e18b3d5dacb9644f63c8ec5a
https://doi.org/10.1073/pnas.0700847104
https://doi.org/10.1073/pnas.0700847104
Publikováno v:
Journal of Biological Chemistry. 279:2038-2045
Angiopoietin-like protein 4 (Angptl4) is a recently identified circulating protein expressed primarily in adipose tissue and liver. Also known as peroxisome proliferator-activated receptor (PPAR)-gamma angiopoietin-related, fasting induced adipose fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43742cbea1a3e8989093a74049e22026
https://doi.org/10.1074/jbc.m307583200
https://doi.org/10.1074/jbc.m307583200
Publikováno v:
Journal of Biological Chemistry. 278:38084-38093
The conversion of vitamin D into an active ligand for the vitamin D receptor requires 25-hydroxylation in the liver and 1α-hydroxylation in the kidney. Mitochondrial and microsomal vitamin D 25-hydroxylase enzymes catalyze the first reaction. The mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b20ab75efbc149f32fa175690cb76e5
https://doi.org/10.1074/jbc.m307028200
https://doi.org/10.1074/jbc.m307028200