Výsledky vyhledávání

Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase

Autor: J Mushack, Hans-U. Häring, E Seffer, Stefanie Tippmer, L Mosthaf, Monika Kellerer, L Berti, K Seedorf, G Kroder

Publikováno v: Journal of Biological Chemistry. 269:3381-3386

Rat-1 fibroblasts stably overexpressing high levels of human insulin receptor were used as a model system to study the effects of hyperglycemia on insulin receptor tyrosine kinase (IRK) activity and protein kinase C (PKC) translocation in parallel in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23ed208a278dab7c64c3f25c9eb7e408
https://doi.org/10.1016/s0021-9258(17)41873-4

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Immunoglobulin heavy chain-binding protein binds to misfolded mutant insulin receptors with mutations in the extracellular domain

Autor: Simeon I. Taylor, Hiroko Kadowaki, Tadashi Kadowaki, L Mosthaf, A Ullrich, Domenico Accili

Publikováno v: Journal of Biological Chemistry. 267:586-590

Cell-surface proteins are transported through the endoplasmic reticulum and Golgi apparatus en route to the plasma membrane. Previously, we have identified three point mutations in the insulin receptor gene that impair transport of the mutant recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::594eeebfcc50874f36b967360dca51fa
https://doi.org/10.1016/s0021-9258(18)48534-1

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Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors

Autor: R. Schumacher, D. Brandenburg, L Mosthaf, Axel Ullrich, Joseph Schlessinger

Publikováno v: Journal of Biological Chemistry. 266:19288-19295

Chimeric insulin/insulin-like growth factor-1 receptors and insulin receptor alpha-subunit point mutants were characterized with respect to their binding properties for insulin and insulin-like growth factor-1 (IGF-1) and their ability to translate l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28325fd5297182e5e303a2cc231562c1
https://doi.org/10.1016/s0021-9258(18)54996-6

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A mutation in the extracellular domain of the insulin receptor impairs the ability of insulin to stimulate receptor autophosphorylation

Autor: Simeon I. Taylor, A Ullrich, L Mosthaf, Domenico Accili

Publikováno v: Journal of Biological Chemistry. 266:434-439

Mutations of the insulin receptor gene have been shown to cause insulin-resistant diabetes in patients with genetic forms of insulin resistance. We have previously reported that a mutation substituting valine for Phe382 in the alpha-subunit of the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f0410513c56b38539bd1514ab8ddd26
https://doi.org/10.1016/s0021-9258(18)52453-4

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Cell-type-specific control elements of the lymphotropic papovavirus enhancer

Autor: B Jostes, Peter Gruss, L Mosthaf, Antonis K. Hatzopoulos, J.R. Erselius

Publikováno v: Journal of Virology

Lymphotropic papovavirus (LPV) exhibits a highly restricted host range, in which only cells of primate B-lymphocyte origin are permissive for infection. Its enhancer element contributes to this tropism, since transcriptional potentiation is confined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba807d858f3bcc71febe5b016f4b427
https://doi.org/10.1128/jvi.64.4.1657-1666.1990

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Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase Cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia

Autor: Y, Ikeda, G S, Olsen, E, Ziv, L L, Hansen, A K, Busch, B F, Hansen, E, Shafrir, L, Mosthaf-Seedorf

Publikováno v: Diabetes. 50(3)

The sand rat (Psammomys obesus) is an animal model of nutritionally induced diabetes. We report here that several protein kinase C (PKC) isoforms (alpha, epsilon, and zeta, representing all three subclasses of PKC) are overexpressed in the skeletal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73046d87548de809ead566fc13c1a744
https://pubmed.ncbi.nlm.nih.gov/11246878

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Insulin signaling is inhibited by micromolar concentrations of H(2)O(2). Evidence for a role of H(2)O(2) in tumor necrosis factor alpha-mediated insulin resistance

Autor: L L, Hansen, Y, Ikeda, G S, Olsen, A K, Busch, L, Mosthaf

Publikováno v: The Journal of biological chemistry. 274(35)

Both hyperglycemia and tumor necrosis factor alpha (TNFalpha) were found to induce insulin resistance at the level of the insulin receptor (IR). How this effect is mediated is, however, not understood. We investigated whether oxidative stress and pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24f0bfc349ce024b8f5534129834fa20
https://pubmed.ncbi.nlm.nih.gov/10455187

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Preface: Antidiabetic Agents: Recent Advances in Their Molecular and Clinical Pharmacology

Autor: L. Mosthaf, H. Laube, M. Kellerer, Hermann P. T. Ammon, Martin A. Wahl, Hans-U. Häring, Eugen J. Verspohl

Introduction. Regulation of Glucose Homeostasis. Clinical Aspects of Diabetes Mellitus. Mechanisms of Insulin Action. Therapeutic Use of Insulin. The Secretory Machinery of Insulin Release. Compounds Acting on Insulin Secretion: Sulphonylureas. Compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::011bf65b3d2fe055bbf83a343fb3d983
https://doi.org/10.1016/s0065-2490(96)80033-5

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